IL70780A - Phosphorus containing compounds as inhibitors of enkephalinases,their preparation and pharmaceutical compositions containing them - Google Patents

Phosphorus containing compounds as inhibitors of enkephalinases,their preparation and pharmaceutical compositions containing them

Info

Publication number
IL70780A
IL70780A IL70780A IL7078084A IL70780A IL 70780 A IL70780 A IL 70780A IL 70780 A IL70780 A IL 70780A IL 7078084 A IL7078084 A IL 7078084A IL 70780 A IL70780 A IL 70780A
Authority
IL
Israel
Prior art keywords
enkephalinases
inhibitors
preparation
pharmaceutical compositions
compositions containing
Prior art date
Application number
IL70780A
Other languages
English (en)
Other versions
IL70780A0 (en
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of IL70780A0 publication Critical patent/IL70780A0/xx
Publication of IL70780A publication Critical patent/IL70780A/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40Esters thereof
    • C07F9/4003Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4056Esters of arylalkanephosphonic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/30Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/301Acyclic saturated acids which can have further substituents on alkyl
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/30Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/32Esters thereof
    • C07F9/3205Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/3211Esters of acyclic saturated acids which can have further substituents on alkyl
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808Acyclic saturated acids which can have further substituents on alkyl
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3882Arylalkanephosphonic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40Esters thereof
    • C07F9/4003Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006Esters of acyclic acids which can have further substituents on alkyl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL70780A 1983-01-28 1984-01-25 Phosphorus containing compounds as inhibitors of enkephalinases,their preparation and pharmaceutical compositions containing them IL70780A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46189583A 1983-01-28 1983-01-28
US54432283A 1983-10-21 1983-10-21

Publications (2)

Publication Number Publication Date
IL70780A0 IL70780A0 (en) 1984-04-30
IL70780A true IL70780A (en) 1988-02-29

Family

ID=27040169

Family Applications (1)

Application Number Title Priority Date Filing Date
IL70780A IL70780A (en) 1983-01-28 1984-01-25 Phosphorus containing compounds as inhibitors of enkephalinases,their preparation and pharmaceutical compositions containing them

Country Status (12)

Country Link
EP (1) EP0117429B1 (cs)
AU (1) AU569719B2 (cs)
CA (1) CA1223266A (cs)
DE (1) DE3465740D1 (cs)
DK (1) DK31784A (cs)
GR (1) GR81744B (cs)
HU (1) HU191987B (cs)
IE (1) IE56605B1 (cs)
IL (1) IL70780A (cs)
NZ (1) NZ206920A (cs)
PH (1) PH22224A (cs)
PT (1) PT78003B (cs)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5217963A (en) * 1985-05-24 1993-06-08 Ciba-Geigy Corporation Certain phosphonic acid quinoline-2-carboxylic acids, esters or amides useful for treatment of disorders responsive to N-methyl D-aspartate receptor blockade
US4906621A (en) * 1985-05-24 1990-03-06 Ciba-Geigy Corporation Certain 2-carboxypiperidyl-alkylene phosphonic acids and esters thereof useful for the treatment of disorders responsive to N-methyl-D-aspartate receptor blockade
US4746653A (en) * 1986-02-28 1988-05-24 Ciba-Geigy Corporation Certain hetero phosphonic acid derivatives of 2-piperidine or 2-tetrahydropyridinecarboxylates and esters thereof which are useful for the treatment of disorders responsive to blockade of the NMDA receptor in mammals
US4749688A (en) * 1986-06-20 1988-06-07 Schering Corporation Use of neutral metalloendopeptidase inhibitors in the treatment of hypertension
EP0254032A3 (en) 1986-06-20 1990-09-05 Schering Corporation Neutral metalloendopeptidase inhibitors in the treatment of hypertension
CA1337400C (en) * 1987-06-08 1995-10-24 Norma G. Delaney Inhibitors of neutral endopeptidase
US4963539A (en) * 1987-09-10 1990-10-16 E. R. Squibb & Sons, Inc. Phosphonate and phosphonamide endopeptidase inhibitors
JP2848411B2 (ja) * 1988-08-18 1999-01-20 サイオス インコーポレイテッド 心房性ナトリウム利尿ペプチドクリアランス阻害剤
DK244090D0 (da) * 1990-10-09 1990-10-09 Novo Nordisk As Kemiske forbindelser
US5155100A (en) * 1991-05-01 1992-10-13 Ciba-Geigy Corporation Phosphono/biaryl substituted dipeptide derivatives
US5294632A (en) * 1991-05-01 1994-03-15 Ciba-Geigy Corporation Phosphono/biaryl substituted dipetide derivatives
US5250522A (en) * 1992-10-09 1993-10-05 Ciba-Geigy Corporation Phosphono/biaryl substituted amino acid derivatives
US5473092A (en) * 1992-11-20 1995-12-05 Monsanto Company Synthesis of optically-active phosphono analogs of succinates
IT1266570B1 (it) * 1993-07-30 1997-01-09 Zambon Spa Derivati della propanammide n-eteroaril sostituiti utili nel trattamento delle malattie cardiovascolari
AU6452098A (en) 1997-03-07 1998-09-22 Metabasis Therapeutics, Inc. Novel purine inhibitors of fructose-1,6-bisphosphatase
ZA981936B (en) * 1997-03-07 1999-09-06 Metabasis Therapeutics Inc Novel benzimidazole inhibitors of fructose 1,6-bisphosphatase.
DE102005022843A1 (de) * 2005-05-18 2006-11-23 Construction Research & Technology Gmbh Phosphor-haltige Monomere, Verfahren zu ihrer Herstellung sowie deren Verwendung
ES2602902T3 (es) 2009-05-28 2017-02-22 Novartis Ag Derivados aminopropiónicos sustituidos como inhibidores de neprilisina
UY32660A (es) 2009-05-28 2010-12-31 Novartis Ag Derivados aminobutricos sustituidos como inhibidores de neprilisina
JO2967B1 (en) 2009-11-20 2016-03-15 نوفارتس ايه جي Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors
BR112015019307A8 (pt) 2013-02-14 2018-01-30 Novartis Ag derivados de ácido butanóico substituído com bisfenila, seus usos, e composição farmacêutica
MA38330B1 (fr) 2013-02-14 2016-09-30 Novartis Ag Dérivés d'acide phosphonique butanoïque de bisphénol substitués en qualité d'inhibiteurs de nep (endopeptidase neutre)
GB201704476D0 (en) 2017-03-21 2017-05-03 Antabio Sas Chemical compounds
KR102833669B1 (ko) 2018-09-25 2025-07-11 앤타바이오 에스에이에스 박테리아 감염의 예방 또는 치료에 사용되는 인단 유도체

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH584232A5 (cs) * 1973-07-26 1977-01-31 Ciba Geigy Ag
US4191552A (en) * 1979-02-02 1980-03-04 Stauffer Chemical Company Amine salts of substituted N-phosphonomethylureas and their use as plant growth regulators
US4272528A (en) * 1980-08-14 1981-06-09 Abbott Laboratories Phosphonoacetyl aminoacids
IE53128B1 (en) * 1981-06-19 1988-07-06 Monsanto Co Herbicidally active monoesters and diesters of n-alkyl substituted amino methyl phosphonic acid and process for preparing the diesters
EP0070131A1 (en) * 1981-07-09 1983-01-19 Analytical Research Pharmaceuticals Pty. Ltd. Phosphonoalkanoylamino acids
AU8571982A (en) * 1981-07-09 1983-01-13 Analytical Research Pharmaceuticals Pty. Ltd. Phosphonoalkanoyl-amino acids
US4396772A (en) * 1981-11-23 1983-08-02 F. R. Squibb & Sons, Inc. Phosphinylalkanoyl amino acids

Also Published As

Publication number Publication date
DK31784D0 (da) 1984-01-24
NZ206920A (en) 1986-10-08
CA1223266A (en) 1987-06-23
IE840155L (en) 1984-07-28
PH22224A (en) 1988-07-01
AU569719B2 (en) 1988-02-18
EP0117429B1 (en) 1987-09-02
PT78003B (en) 1986-06-18
HUT34511A (en) 1985-03-28
AU2373684A (en) 1984-08-02
PT78003A (en) 1984-02-01
HU191987B (en) 1987-04-28
DK31784A (da) 1984-07-29
DE3465740D1 (en) 1987-10-08
GR81744B (cs) 1984-12-12
IE56605B1 (en) 1991-10-09
EP0117429A1 (en) 1984-09-05
IL70780A0 (en) 1984-04-30

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