IL63198A - Dealkylation of tertiary amines with alpha-chlorinated chloroformates - Google Patents

Dealkylation of tertiary amines with alpha-chlorinated chloroformates

Info

Publication number
IL63198A
IL63198A IL63198A IL6319881A IL63198A IL 63198 A IL63198 A IL 63198A IL 63198 A IL63198 A IL 63198A IL 6319881 A IL6319881 A IL 6319881A IL 63198 A IL63198 A IL 63198A
Authority
IL
Israel
Prior art keywords
alpha
substituted
see diagramm
unsubstituted
chlorinated
Prior art date
Application number
IL63198A
Other versions
IL63198A0 (en
Original Assignee
Poudres & Explosifs Ste Nale
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Poudres & Explosifs Ste Nale filed Critical Poudres & Explosifs Ste Nale
Publication of IL63198A0 publication Critical patent/IL63198A0/en
Publication of IL63198A publication Critical patent/IL63198A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/023—Preparation; Separation; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1. Process for the dealkylation of a tertiary amine carrying at least one alkyl radical of the formula see diagramm : EP0045234,P11,F1 in which R1 and R2 represent saturated or unsaturated, substituted or unsubstituted aliphatic or cycloaliphatic radicals or substituted or unsubstituted aromatic radicals, it being for the radicals R1 and R2 to be chemically bonded to one another so as to form a substituted or unsubstituted ring, and R3 represents an aliphatic radical, characterised in that an alpha-chlorinated chloroformate of the formula see diagramm : EP0045234,P11,F2 in which R4 represents a saturated aliphatic radical which is unsubstituted or substituted by halogen atoms, is reacted with the amine see diagramm : EP0045234,P11,F3 so as to obtain an alpha-chlorinated carbamate of the formula see diagramm : EP0045234,P11,F4 in which R1 , R2 and R4 have the same meaning as above, and in that the alpha-chlorinated carbamate thus obtained is treated with a light hydroxylated solvent of the formula R5 , in which R5 represents a linear or branched aliphatic radical containing from 1 to 4 carbon atoms or a hydrogen atom, so as to obtain the dealkylated amine of the formula see diagramm : EP0045234,P11,F5 in which R1 and R2 have the above meanings.
IL63198A 1980-07-24 1981-06-29 Dealkylation of tertiary amines with alpha-chlorinated chloroformates IL63198A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8016311A FR2487340A1 (en) 1980-07-24 1980-07-24 NOVEL PROCESS FOR THE DEALKYLATION OF TERTIARY AMINES BY USE OF A-CHLORINE CHLOROFORMIATES

Publications (2)

Publication Number Publication Date
IL63198A0 IL63198A0 (en) 1981-09-13
IL63198A true IL63198A (en) 1984-07-31

Family

ID=9244477

Family Applications (1)

Application Number Title Priority Date Filing Date
IL63198A IL63198A (en) 1980-07-24 1981-06-29 Dealkylation of tertiary amines with alpha-chlorinated chloroformates

Country Status (10)

Country Link
EP (1) EP0045234B1 (en)
JP (1) JPS5753415A (en)
AT (1) ATE7597T1 (en)
CA (1) CA1173439A (en)
DE (1) DE3163747D1 (en)
DK (1) DK171764B1 (en)
ES (1) ES8204981A1 (en)
FR (1) FR2487340A1 (en)
HU (1) HU188065B (en)
IL (1) IL63198A (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2551058B1 (en) * 1983-08-26 1986-09-26 Poudres & Explosifs Ste Nale PROCESS FOR THE PREPARATION OF A-CHLORINATED CHLOROFORMIATES
US6321720B1 (en) 1998-11-16 2001-11-27 Sanshin Kogyo Kabushiki Kaisha Intake system for four-cycle engine powering an outboard motor
WO2011116491A1 (en) * 2010-03-22 2011-09-29 北京世纪迈劲生物科技有限公司 Preparation method for nortropine benzilate and its salts and intermediates used in said method

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3905981A (en) * 1973-10-12 1975-09-16 Research Corp N-dealkylation of tertiary amines

Also Published As

Publication number Publication date
EP0045234B1 (en) 1984-05-23
ES503754A0 (en) 1982-06-01
EP0045234A1 (en) 1982-02-03
HU188065B (en) 1986-03-28
CA1173439A (en) 1984-08-28
JPH029565B2 (en) 1990-03-02
DK325681A (en) 1982-01-25
DK171764B1 (en) 1997-05-12
FR2487340A1 (en) 1982-01-29
FR2487340B1 (en) 1983-09-02
IL63198A0 (en) 1981-09-13
ES8204981A1 (en) 1982-06-01
JPS5753415A (en) 1982-03-30
DE3163747D1 (en) 1984-06-28
ATE7597T1 (en) 1984-06-15

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