IL60272A0 - 7 and 7-8 substituted 4,5 -epoxymorphinan-6-one compounds - Google Patents

7 and 7-8 substituted 4,5 -epoxymorphinan-6-one compounds

Info

Publication number
IL60272A0
IL60272A0 IL60272A IL6027280A IL60272A0 IL 60272 A0 IL60272 A0 IL 60272A0 IL 60272 A IL60272 A IL 60272A IL 6027280 A IL6027280 A IL 6027280A IL 60272 A0 IL60272 A0 IL 60272A0
Authority
IL
Israel
Prior art keywords
epoxymorphinan
substituted
compounds
Prior art date
Application number
IL60272A
Original Assignee
Miles Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Miles Lab filed Critical Miles Lab
Publication of IL60272A0 publication Critical patent/IL60272A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/28—Morphinans

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL60272A 1979-07-11 1980-06-09 7 and 7-8 substituted 4,5 -epoxymorphinan-6-one compounds IL60272A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/056,549 US4272541A (en) 1978-06-02 1979-07-11 7,8 and 7-8 Substituted 4,5α-epoxymorphinan-6-one compounds, and methods of treating pain and drug dependence with them

Publications (1)

Publication Number Publication Date
IL60272A0 true IL60272A0 (en) 1980-09-16

Family

ID=22005135

Family Applications (1)

Application Number Title Priority Date Filing Date
IL60272A IL60272A0 (en) 1979-07-11 1980-06-09 7 and 7-8 substituted 4,5 -epoxymorphinan-6-one compounds

Country Status (6)

Country Link
US (1) US4272541A (en)
EP (1) EP0023576B1 (en)
JP (1) JPS582956B2 (en)
CA (1) CA1135691A (en)
DE (1) DE3060589D1 (en)
IL (1) IL60272A0 (en)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4275205A (en) * 1980-05-05 1981-06-23 Miles Laboratories, Inc. 7,7-Ditosyloxymethyl-4,5α-epoxy-morphinan-6-ols
US4987136A (en) * 1982-03-16 1991-01-22 The Rockefeller University Method for controlling gastrointestinal dysmotility
DE3381877D1 (en) * 1982-03-16 1990-10-18 Univ Rockefeller USE OF OPIUM ANTAGONISTS FOR THE PRODUCTION OF MEDICINAL PRODUCTS FOR THE REMEDY OF GASTRO-INTESTINAL DISORDERS.
US5977326A (en) * 1991-08-06 1999-11-02 Salford Ultrafine Chemicals And Research Limited Process for making morphine-6-glucuronide or substituted morphine-6-glucuronide
US7220737B1 (en) 1997-09-04 2007-05-22 Novoneuron, Inc Noribogaine in the treatment of pain and drug addiction
ES2395268T3 (en) * 1997-09-04 2013-02-11 Demerx, Inc. Noribogaine for the treatment of pain and drug addiction
AUPQ968300A0 (en) * 2000-08-25 2000-09-21 Glaxo Wellcome Australia Ltd Chemical methods
US7923454B2 (en) * 2002-05-17 2011-04-12 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
EP2987788A1 (en) 2002-05-17 2016-02-24 Taiwanj Pharmaceuticals Co., Ltd. Opioid and opioid-like compounds and uses thereof
US7501433B2 (en) * 2002-05-17 2009-03-10 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
US8017622B2 (en) 2003-05-16 2011-09-13 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
WO2006126529A1 (en) * 2005-05-25 2006-11-30 Shionogi & Co., Ltd. 6,7-unsaturated-7-carbamoyl substituted morphinan derivative
DE602006019246D1 (en) 2005-06-16 2011-02-10 Mallinckrodt Inc SYNTHETIC ROUTE TO 14-HYDROXYLOPIATES OVER 1-HALOGENHEBINE OR ANALOG
PL2222643T3 (en) * 2007-12-17 2019-12-31 SpecGx LLC Sinomenine derivatives and processes for their synthesis
US9394294B2 (en) 2010-05-11 2016-07-19 Demerx, Inc. Methods and compositions for preparing and purifying noribogaine
US8362007B1 (en) 2010-05-11 2013-01-29 Demerx, Inc. Substituted noribogaine
US8765737B1 (en) 2010-05-11 2014-07-01 Demerx, Inc. Methods and compositions for preparing and purifying noribogaine
US9586954B2 (en) 2010-06-22 2017-03-07 Demerx, Inc. N-substituted noribogaine prodrugs
US8637648B1 (en) 2010-06-22 2014-01-28 Demerx, Inc. Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier
US8741891B1 (en) 2010-06-22 2014-06-03 Demerx, Inc. N-substituted noribogaine prodrugs
US8802832B2 (en) 2010-06-22 2014-08-12 Demerx, Inc. Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier
EP2595632A1 (en) 2010-07-23 2013-05-29 DemeRx, Inc. Noribogaine compositions
EP2481740B1 (en) 2011-01-26 2015-11-04 DemeRx, Inc. Methods and compositions for preparing noribogaine from voacangine
US9617274B1 (en) 2011-08-26 2017-04-11 Demerx, Inc. Synthetic noribogaine
JP2015500833A (en) 2011-12-09 2015-01-08 デメレックス， インコーポレイテッド Nolibogaine phosphate
US9150584B2 (en) 2012-01-25 2015-10-06 Demerx, Inc. Indole and benzofuran fused isoquinuclidene derivatives and processes for preparing them
CA2858820C (en) 2012-01-25 2021-08-17 Demerx, Inc. Synthetic voacangine
US8940728B2 (en) 2012-12-20 2015-01-27 Demerx, Inc. Substituted noribogaine
US9045481B2 (en) 2012-12-20 2015-06-02 Demerx, Inc. Substituted noribogaine
EP2934541A4 (en) 2012-12-20 2016-08-03 Demerx Inc Substituted noribogaine
US8946255B2 (en) 2012-12-28 2015-02-03 Purdue Pharma L.P. Substituted morphinans and the use thereof
GB201313915D0 (en) 2013-08-02 2013-09-18 Johnson Matthey Plc Process
WO2015195673A2 (en) 2014-06-18 2015-12-23 Demerx, Inc. Halogenated indole and benzofuran derivatives of isoquinuclidene and processes for preparing them
KR102343018B1 (en) 2014-06-30 2021-12-27 코닌클리케 필립스 엔.브이. Anti-fouling system using energy harvested from salt water

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2766245A (en) * 1956-10-09 dehydroisomorphinanes intermedi-
US2178010A (en) * 1937-02-03 1939-10-31 Small Lyndon Frederick Nuclear substituted derivatives of the morphine series and methods for their preparation
CH414663A (en) * 1959-12-29 1966-06-15 Shionogi & Co Process for the preparation of D- and L-morphinane derivatives
US3300500A (en) * 1962-04-09 1967-01-24 Alkylmorphinan derivatives and production thereof
US3332950A (en) * 1963-03-23 1967-07-25 Endo Lab 14-hydroxydihydronormorphinone derivatives
IL26896A (en) * 1966-01-19 1970-11-30 Endo Lab 14-hydroxynormorphines and 14-hydroxynormorphinones
DE2538075A1 (en) * 1975-08-27 1977-03-17 Boehringer Sohn Ingelheim N-TETRAHYDROFURFURYL NOROXYMORPHONES, THEIR ACID ADDITIONAL SALTS, THE MEDICINAL PRODUCTS AND THE METHOD FOR THEIR MANUFACTURING
US4089855A (en) * 1976-04-23 1978-05-16 Cornell Research Foundation, Inc. Process for the stereoselective reduction of 6- and 8-keto morphine and morphinan derivatives with formamidinesulfinic acid and compounds obtained thereby
CA1093070A (en) * 1978-02-10 1981-01-06 Michael P. Kotick 8.beta.-ALKYL-SUBSTITUTED MORPHINAN-6-ONE COMPOUNDS
IL56222A (en) * 1978-02-10 1981-11-30 Miles Lab 3-hydroxy(and methoxy)-17-substituted-8beta-ethyl-(and 8beta-methyl)-4,5alpha-epoxymorphinan-6-one compounds and their production
US4232028A (en) * 1979-06-18 1980-11-04 Sisa, Incorporated 17-Cyclobutylmethyl-4,5α-epoxy-3-hydroxy-14-methoxy-8α-methylmorphinan-6-one, and method of treating pain with it

Also Published As

Publication number Publication date
EP0023576A1 (en) 1981-02-11
EP0023576B1 (en) 1982-06-23
JPS5615290A (en) 1981-02-14
DE3060589D1 (en) 1982-08-12
JPS582956B2 (en) 1983-01-19
US4272541A (en) 1981-06-09
CA1135691A (en) 1982-11-16

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