IL43475A - A nonabsorbable,nonnutritive water-soluble flavoring composition and process for preparing the same - Google Patents
A nonabsorbable,nonnutritive water-soluble flavoring composition and process for preparing the sameInfo
- Publication number
- IL43475A IL43475A IL43475A IL4347573A IL43475A IL 43475 A IL43475 A IL 43475A IL 43475 A IL43475 A IL 43475A IL 4347573 A IL4347573 A IL 4347573A IL 43475 A IL43475 A IL 43475A
- Authority
- IL
- Israel
- Prior art keywords
- flavoring
- agent
- composition
- controlling means
- controlling
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/70—Fixation, conservation, or encapsulation of flavouring agents
- A23L27/75—Fixation, conservation, or encapsulation of flavouring agents the flavouring agents being bound to a host by chemical, electrical or like forces, e.g. use of precursors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/24—Ethers with hydroxy compounds containing no oxirane rings with polyhydroxy compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
- C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nutrition Science (AREA)
- Polymers & Plastics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Food Science & Technology (AREA)
- Seasonings (AREA)
- Medicinal Preparation (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (10)
1. A nonabsorbable, nonnutritive,(flavoring composition comprised of an active flavoring agent covalently , bonded through a position on the active flavoring agent that is nonessential for its flavoring activity, with a covalent bond that maintains its physical and chemical integrity in the gastrointestinal tract to a controlling means that is essentially nonmetabolizable and nonabsorbable, and which controlling means maintains the active flavoring agent within the gastrointestinal tract by substantially restricting passage of the composition through the mucosa of the gastrointestinal tract.
2. The flavoring composition of Claim 1 wherein the controlling means is a hydrophilic water soluble organic polymer having an average molecular weight of from 2,500 to 250,000.
3. The flavoring composition of Claim 2 wherein the organic polymer contains not less than one polar functional group selected from the group consisting of amide, amino, carboxyl, ether and hydroxy1 functional groups the ' \ ;■■ ·■ for each three carbon atoms; resent on/average in the organic polymer. ·" ·'>·· ■■■> ;
4. The flavoring composition of Claim 3 wherein the flavoring agent is. bonded to the controlling means through a nonrupturable nondegradable organic bridge which permits 1 the agent to be at least 5 atoms from the controlling means.
5. The flavoring composition of Claim 3 wherein the active flavoring agent is a sweetening agent and the composition is soluble in water to an amount of not less than 100 ppm. 5
6. The flavoring composition of Claim (£ wherein the sweetening agent comprises an aromatic phenol or an aromatic amine .
7. The process for preparing a nonabsorbable ,Γηοη- nutritive form of a flavoring agent which comprises bonding . said agent through a nonrupturable, nondigestable covalent linkage to a controlling molecule, said controlling molecule being nonmetabolizable and of molecular dimensions which ; control and restrict its movement across the walls of the digestive tract, and thereafter recovering the controlling molecule having agent bonded thereto .
8. The process of Claim 7 wherein the controlling molecule is hydrophilic and has a molecular weight of from 2,500 to 250,000.
9. The process of Claim 8 wherein the flavoring agent is a sweetening agent.
10. The flavoring composition of Claim 1 wherein controlling means is a polymer of molecular weight 2,500 to 250,000, which comprises the active flamonomeric voring agent unit. il. The process of rendering nonnutritive a flavoring agent which comprises joining said flavoring agent by a nonrupturable , nondigestable covalent linkage to a polymeric molecule of molecular weight 2,500 to 250,000, and of molecular dimensions which control and prevent its movement across the walls of the digestive tract. .ttori ey for pp icants
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30085772A | 1972-10-25 | 1972-10-25 | |
US300499A US3876816A (en) | 1972-10-25 | 1972-10-25 | Nonabsorbable, nonnutritive sweeteners |
Publications (2)
Publication Number | Publication Date |
---|---|
IL43475A0 IL43475A0 (en) | 1974-01-14 |
IL43475A true IL43475A (en) | 1976-04-30 |
Family
ID=26971813
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL43475A IL43475A (en) | 1972-10-25 | 1973-10-24 | A nonabsorbable,nonnutritive water-soluble flavoring composition and process for preparing the same |
Country Status (10)
Country | Link |
---|---|
JP (1) | JPS5631944B2 (en) |
CA (1) | CA1011986A (en) |
CH (1) | CH591215A5 (en) |
DE (1) | DE2352905A1 (en) |
FR (1) | FR2204369B1 (en) |
GB (1) | GB1423700A (en) |
IL (1) | IL43475A (en) |
IT (1) | IT1047950B (en) |
NL (1) | NL7314587A (en) |
SU (1) | SU508160A3 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2390111B1 (en) * | 1977-01-21 | 1988-02-19 | Polak Frutal Works | PROCESS FOR FIXING FLAVORING ALDEHYDES FOR THEIR APPLICATION IN THE FOOD FIELD |
US4448789A (en) * | 1982-08-27 | 1984-05-15 | Warner-Lambert Company | Enhanced flavor-releasing agent |
IT1186782B (en) * | 1985-10-18 | 1987-12-16 | Montedison Spa | PROCESS FOR THE PREPARATION OF PHENYLPROPANONS |
GB0916178D0 (en) * | 2009-09-15 | 2009-10-28 | Givaudan Sa | Organic compounds |
-
1973
- 1973-10-16 GB GB4814473A patent/GB1423700A/en not_active Expired
- 1973-10-22 DE DE19732352905 patent/DE2352905A1/en not_active Withdrawn
- 1973-10-24 IL IL43475A patent/IL43475A/en unknown
- 1973-10-24 NL NL7314587A patent/NL7314587A/xx not_active Application Discontinuation
- 1973-10-24 CA CA184,141A patent/CA1011986A/en not_active Expired
- 1973-10-24 FR FR7337881A patent/FR2204369B1/fr not_active Expired
- 1973-10-24 JP JP11906373A patent/JPS5631944B2/ja not_active Expired
- 1973-10-24 CH CH1500473A patent/CH591215A5/xx not_active IP Right Cessation
- 1973-10-24 SU SU1970654A patent/SU508160A3/en active
- 1973-10-24 IT IT53332/73A patent/IT1047950B/en active
Also Published As
Publication number | Publication date |
---|---|
IL43475A0 (en) | 1974-01-14 |
JPS5631944B2 (en) | 1981-07-24 |
SU508160A3 (en) | 1976-03-25 |
JPS49100266A (en) | 1974-09-21 |
CA1011986A (en) | 1977-06-14 |
FR2204369A1 (en) | 1974-05-24 |
AU6144173A (en) | 1975-04-17 |
DE2352905A1 (en) | 1974-05-09 |
NL7314587A (en) | 1974-04-29 |
GB1423700A (en) | 1976-02-04 |
IT1047950B (en) | 1980-10-20 |
FR2204369B1 (en) | 1979-10-19 |
CH591215A5 (en) | 1977-09-15 |
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