IL41928A - Indane derivatives,their preparation and pharmaceutical compositions containing them - Google Patents
Indane derivatives,their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL41928A IL41928A IL41928A IL4192873A IL41928A IL 41928 A IL41928 A IL 41928A IL 41928 A IL41928 A IL 41928A IL 4192873 A IL4192873 A IL 4192873A IL 41928 A IL41928 A IL 41928A
- Authority
- IL
- Israel
- Prior art keywords
- compound
- inden
- compounds
- amine
- maleate
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims 2
- 125000003392 indanyl group Chemical class C1(CCC2=CC=CC=C12)* 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 claims 45
- 125000000217 alkyl group Chemical group 0.000 claims 17
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims 11
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 11
- 239000001257 hydrogen Substances 0.000 claims 9
- 229910052739 hydrogen Inorganic materials 0.000 claims 9
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 7
- 125000004432 carbon atom Chemical group C* 0.000 claims 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 6
- 238000000034 method Methods 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 5
- -1 alkylomino Chemical group 0.000 claims 4
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 3
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims 3
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 3
- 229960001270 d- tartaric acid Drugs 0.000 claims 3
- 125000004663 dialkyl amino group Chemical group 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
- 238000006268 reductive amination reaction Methods 0.000 claims 3
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 125000003282 alkyl amino group Chemical group 0.000 claims 2
- 150000001412 amines Chemical class 0.000 claims 2
- 238000006243 chemical reaction Methods 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 150000002576 ketones Chemical class 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- NTOIKDYVJIWVSU-WOJBJXKFSA-N (2r,3r)-2,3-dihydroxy-2,3-bis(4-methylbenzoyl)butanedioic acid Chemical class C1=CC(C)=CC=C1C(=O)[C@@](O)(C(O)=O)[C@](O)(C(O)=O)C(=O)C1=CC=C(C)C=C1 NTOIKDYVJIWVSU-WOJBJXKFSA-N 0.000 claims 1
- YBYIRNPNPLQARY-UHFFFAOYSA-N 1H-indene Chemical compound C1=CC=C2CC=CC2=C1 YBYIRNPNPLQARY-UHFFFAOYSA-N 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 230000002152 alkylating effect Effects 0.000 claims 1
- 230000029936 alkylation Effects 0.000 claims 1
- 238000005804 alkylation reaction Methods 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 239000004202 carbamide Substances 0.000 claims 1
- 239000003054 catalyst Substances 0.000 claims 1
- 238000009903 catalytic hydrogenation reaction Methods 0.000 claims 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229940012017 ethylenediamine Drugs 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 229910052500 inorganic mineral Inorganic materials 0.000 claims 1
- 238000010255 intramuscular injection Methods 0.000 claims 1
- 239000007927 intramuscular injection Substances 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 claims 1
- 239000011707 mineral Substances 0.000 claims 1
- 150000007522 mineralic acids Chemical class 0.000 claims 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 229910000510 noble metal Inorganic materials 0.000 claims 1
- 231100000252 nontoxic Toxicity 0.000 claims 1
- 230000003000 nontoxic effect Effects 0.000 claims 1
- 150000007524 organic acids Chemical class 0.000 claims 1
- 235000005985 organic acids Nutrition 0.000 claims 1
- 150000002900 organolithium compounds Chemical class 0.000 claims 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
- 238000005932 reductive alkylation reaction Methods 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- ZVCDLGYNFYZZOK-UHFFFAOYSA-M sodium cyanate Chemical compound [Na]OC#N ZVCDLGYNFYZZOK-UHFFFAOYSA-M 0.000 claims 1
- 238000010254 subcutaneous injection Methods 0.000 claims 1
- 239000007929 subcutaneous injection Substances 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
- C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
- C07D295/033—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/657—Unsaturated compounds containing a keto groups being part of a ring containing six-membered aromatic rings
- C07C49/683—Unsaturated compounds containing a keto groups being part of a ring containing six-membered aromatic rings having unsaturation outside the aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1722272A GB1409551A (en) | 1972-04-14 | 1972-04-14 | Cyclopent a indene derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL41928A0 IL41928A0 (en) | 1973-06-29 |
| IL41928A true IL41928A (en) | 1976-08-31 |
Family
ID=10091380
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL41928A IL41928A (en) | 1972-04-14 | 1973-04-02 | Indane derivatives,their preparation and pharmaceutical compositions containing them |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US3952050A (de) |
| JP (1) | JPS4914455A (de) |
| AT (1) | AT333740B (de) |
| AU (1) | AU471517B2 (de) |
| BE (1) | BE798020A (de) |
| CA (1) | CA994344A (de) |
| CH (1) | CH589038A5 (de) |
| DE (1) | DE2317432A1 (de) |
| FR (1) | FR2182963B1 (de) |
| GB (1) | GB1409551A (de) |
| IE (1) | IE37473B1 (de) |
| IL (1) | IL41928A (de) |
| NL (1) | NL7305257A (de) |
| SE (1) | SE395884B (de) |
| ZA (1) | ZA732247B (de) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6432954B1 (en) | 2000-07-14 | 2002-08-13 | Targacept, Inc. | Pharmaceutical compositions and methods for use |
| US6743812B1 (en) | 2000-07-14 | 2004-06-01 | Targacept, Inc. | Pharmaceutical compositions and methods for use |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1282648B (de) * | 1964-01-27 | 1968-11-14 | Shionogi & Co | 11-Methylamino-9, 10-aethano-9, 10-dihydroanthracen und dessen pharmazeutisch vertraegliche saure Additionssalze sowie Verfahren zu deren Herstellung |
| US3291828A (en) * | 1964-07-02 | 1966-12-13 | Shionogi & Co | 6-amino-6, 7-dihydro-5h-dibenzo [a, c] cycloheptenes |
| US3704323A (en) * | 1969-12-23 | 1972-11-28 | Squibb & Sons Inc | Indane derivatives |
-
1972
- 1972-04-14 GB GB1722272A patent/GB1409551A/en not_active Expired
-
1973
- 1973-03-28 IE IE495/73A patent/IE37473B1/xx unknown
- 1973-04-02 IL IL41928A patent/IL41928A/en unknown
- 1973-04-02 ZA ZA732247A patent/ZA732247B/xx unknown
- 1973-04-03 US US05/347,477 patent/US3952050A/en not_active Expired - Lifetime
- 1973-04-03 CA CA168,311A patent/CA994344A/en not_active Expired
- 1973-04-05 AU AU54129/73A patent/AU471517B2/en not_active Expired
- 1973-04-06 DE DE2317432A patent/DE2317432A1/de active Pending
- 1973-04-10 BE BE129857A patent/BE798020A/xx unknown
- 1973-04-10 AT AT313473A patent/AT333740B/de not_active IP Right Cessation
- 1973-04-12 CH CH520373A patent/CH589038A5/xx not_active IP Right Cessation
- 1973-04-12 SE SE7305219A patent/SE395884B/xx unknown
- 1973-04-12 FR FR7313266A patent/FR2182963B1/fr not_active Expired
- 1973-04-13 NL NL7305257A patent/NL7305257A/xx not_active Application Discontinuation
- 1973-04-13 JP JP48042088A patent/JPS4914455A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| NL7305257A (de) | 1973-10-16 |
| CH589038A5 (de) | 1977-06-30 |
| SE395884B (sv) | 1977-08-29 |
| IL41928A0 (en) | 1973-06-29 |
| AU471517B2 (en) | 1976-04-29 |
| CA994344A (en) | 1976-08-03 |
| DE2317432A1 (de) | 1973-10-31 |
| ZA732247B (en) | 1974-01-30 |
| US3952050A (en) | 1976-04-20 |
| FR2182963B1 (de) | 1976-04-09 |
| AT333740B (de) | 1976-12-10 |
| ATA313473A (de) | 1976-04-15 |
| GB1409551A (en) | 1975-10-08 |
| IE37473B1 (en) | 1977-08-03 |
| FR2182963A1 (de) | 1973-12-14 |
| IE37473L (en) | 1973-10-14 |
| BE798020A (fr) | 1973-10-10 |
| JPS4914455A (de) | 1974-02-07 |
| AU5412973A (en) | 1974-10-10 |
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