IL37601A - Pharmaceutical compositions containing 6-membered azacyclic compounds,certain novel such compounds and their preparation - Google Patents

Claims (17)

H-85/95-ls* . . WHAT WE CLAIM IS:-

1. A pharmaceutical composition comprising a heterocyclic compound of the general formula in wtich the dotted line represents an optional double bond; W represents a cycloalkyl radical containing five to seven ring carbon atoms or a phenyl, naphthyl, tetrahydronaphthyl , indenyl, thienyl, benzo[b]thienyl , pyrrolyl , imidazolyl , pyrazolyl , pyrimidinyl , quinolyl ,; thiazolyl, benzimidazolyl, benzo-l, -dioxanylypyridyl or benzindolyl radical, all of which radicals may be unsubstituted or substituted by one or more of the following: halogen, lower alkyl, lower alkoxy, lower alkoxycarbonyl, hydroxy, phenyl, halophenyl, lower alkanoylamino , nitro, amino and lower alkylenedioxy; A represents a lower alkylene radical, a mono- or di-keto lower-alkylene radical or an unsubstituted hydrazone derivative thereof, a hydroxy-lower-alkylene radical, or a. bivalent radical of the fz-r~s.li OH -NH-CO-(CH2) -N-CH2.C≡CoCH2-, -0-CH2CH.CH2- or cyl -0-( lower-alkylene)-, R"^ represents hydrogen, R represents a cycloalkyl of 5 to 7 carbon atoms, lower alkyl, lower alkoxy¾thienyl or phenyl radical which may be substituted by one or more of the H-85/95-Is following: halogen, lower alkyl, lower alkoxy, methylene- dioxy and ' trihalomethyl ; n is the integer 1,2 or 3* Acyl is an acyl radical; and the term "lower" means the radical contains from 1 to 6 carbon atoms; and the acid addition and quaternary ammonium salts thereof; with the proviso that when R is lower alkyl and A is a -C^CI^- radical, then W is other than thienyl, pyridyl, pyrrolyl, imidazolyl, pyrazolyl, pyrimidinyl or thiazolyl; in conjunction with a non- oxic carrier; with the further proviso that when W is unsubstituted phenyl, and A is methylene or ethylene, and R is phenyl, which may be substituted as defined above or unsubstituted, or lower-alkyl, and is a piperidine ring, then the carrier excludes water and common organic solvents as sole carrier. „ A pharmaceutical composition according to Claim 1, wherein W is phenyl, A is an ethylene radical, R is phenyl or benzyl β » A pharmaceutical composition according to Claim 1, wherein W is phenyl, A is methylene and R is phenyl, p-chlorophenyl or p-methylphenyl., „ A pharmaceutical composition according to Claim 1, wherein W is phenyl, A is an ethylene radical and R is methyl. ·. A pharmaceutical composition according to any one of Claims 2, 3 and 4, wherein piperidine ring, and R is as defined in any one laims 2 or „ 37601 -2 H-85/95-Is* · * " o A pharmaceutical composition according to any one of Claims 1 , 2 and 5 , wherein the heterocyclic compound is 1-phenethyl—'4-benzainidopiperidine,, o A pharmaceutical composition according to any one of Claims 1 and 2 , wherein the heterocyclic compound · is l-phenethyl- -benzamido- 1 , 2 , 5 , 6-tetrahydropyridine» o A pharmaceutical composition according to Claim 1 , wherein the composition is in the form of a tablet or capsule o o A pharmaceutical composition according to any one of ■ Claims 2 to 7 i wherein the composition is in the form of a tablet or capsule β o Heterocyclic compounds of the general formula in which the general formula 11(a) 11(b) 11(c) . . · j W represents a cycloalkyl radical containing five to seven ring carbon atoms or a" phenyl, naphthyl, tetra- "¾hiep l, hydronaphthyl, indenyl ,/benzo LbJthienyl , pyrrolyl , H-85/95-Is imidazolyl, pyrazolyl, pyridyl, pyrimidyl, quinolyl, thiazolyl, benzimidazolyl , benzo-1 ,4-dioxanyl or benzindolyl radical, all of which radicals may be substituted by one or more of the following; halogen, lower alkyl, lower alkoxy, lower alkoxycarbonyl , hydroxy, phenyl, halophenyl, lower alkanoylamino, nitro, amino, and lower alkylenedioxy; A represents a lower alkylene radical, a mono- or di-keto lower-alkylene radical or an unsubstituted hydrazone derivative thereof, a hydroxy-lower-alkylene radical, or a bivalent radical of the formula -NH-C0-(CHo) - , n - I-CHc0oC≡CoCH -, or -0-(lower-alkylene)- ; Acyl B?~ represents hydrogen; n is the integer 1, 2 or 3; Acyl is an acyl radical; is an anion; R is hydrogen or the group -COR when ^*®2 represents a ring system of formula 11(a) or 11(c) and the group -COR when represents a ring system of formula 11(b) wherein R represents a cycloalkyl containing five to seven ring carbon atoms, lower alkoxy, lower alkyl, thienyl or phenyl radical, which may be substituted by one or more of the following: halogen lower alkyl, lower alkoxy, methylenedioxy and trihalo-methyl; and the term "lower" means that the radical contains from 1 to 6 carbon atoms; and the acid addition ammonium salts of those compounds wherein represents a ring system of formula 11(b) or 11(c); with the provisos that (i) when W is unsubstituted phenyl, and A is methylene H-85/95-Is* phenyl, which may he unsubstitruted or substituted as hereinbefore defined, or lower alkyl, then the ring system is a ring system of formula 11(a) or 11(b); (ii) when is pyridyl, thienyl pyrimidinyl, imidazolyl, pyrrolyl, pyrazolyl or thiazo-tyl, all of which may be unsubstiruted or substituted as hereinbefore defined, and A is a OH 1 2 -CHCHg- or -CHgCHg- radical, then R is the group COR wherein R is other than lower alkyl; (iii) when W is a phenyl or thienyl, pyrrolyl, imidazolyl, pyrazolyl, pyrimidinyl or thiazolyl, all of which may be unsubstituted or substituted as 11 hereinbefore defi CHp- radical, and the ring system is a ring system of formula the group -COR wherein R is other than lower alkyl; (iv) when W is phenyl which may be unsubstituted or substituted OH as hereinbefore defined and A is a _QJJ_QJJ _ radical, 2 then R is the group -COR wherein R is other than lower alkyl; (v) when W is unsubstituted phenyl or 2 phenyl substituted by a nitro radical and R is hydrogen then A is other than methylene or ethylene and (vi) when W is unsubstituted phenyl and A is -0-( ethylene) then R is other than hydrogene H-85/95-fl Heterocyclic compounds according to Claim 10 , in which i-R1 » ν/,^,^,Η,Χ θ , Acyl and the term "lower" have the meanings defined in Claim 10 , and A represents a lower alkylene radical, a mono- or di-keto lower alkylene radical or a hydroxy lower-alkylene radical or a bivalent radical of the formula -NHo C0oCH -9 OH ^ NHoCOoCH2oCH2-, - .CH2oC≡CoCH2-, -0-CH2 oCHoCH2- or Acyl -0 - ( lower-alkylene) -,. Heterocyclic compounds according to Claim 11 , in which , Acyl and the term "lower" have the meanings defined in Claim 11, and A represents a lower alkylene radical o o Heterocyclic compounds according to Claim 12 , in which the lower alkylene radical A is a -CH2-, -(CH2)^- or -(CH2)^- radical o o Heterocyclic compounds according to Claim 12 , in which the lower alkylene radical A is a -(CH2)2-radical. o Heterocyclic compounds according to Claim 11 , in which a NHR2 , ν,Ε^-,^,Ε,Χ θ , Acyl and the term "lower" R1 have the meanings defined in Claim 11 , and A represents H-85/95-fl o Heterocyclic compounds according to Claim 15, in which the mono-keto lower alkylene radical A has the formula -C0oCH2- or -C0„(CH2)2-o » Heterocyclic compounds according to Claim 15, in which the mono-keto lower alkylene radical A has the formula -C0-(CHo)x-<, ording to Claim 11, in which , Acyl and the term "lower" ave tne meanings defined in Claim ll, and A represents a diketo lower alkylene radical. Heterocyclic compounds according to Claim 18, in which the diketo lower alkylene radical A is a -COoCO- radical, Heterocyclic compounds according to Claim 11, in which , Acyl and the term "lower" n Claim 11, «nd A represents a hydroxy lower alkylene radical. Heterocyclic compounds according to Claim 20, in which the hydroxy lower alkylene radical A is a~CHoCH2-, OH - 5- radical, o Heterocyclic compounds according to Claim 11, in which -N ' ) , W,R 1 ,R2,R,X β° , Acyl and the term "lower" have the meanings defined in Claim 11, and A represents a -NH.C0*CH2- or -NHoC0o (CH2)2- radicalo Heterocyclic compounds according to any one of Claims 11 to 22 , in which W is a phenyl, mono- or di- halophenyl, mono-, di- or tri-lower alkoxy-phenyl , mono- or di-lower alkylphenyl, aminophenyl, nitrophenyl, methylenedioxy -phenyl, naphthyl, quinolyl, dihydroxyphenyl, pyridyl, pyrimidyl or pyrrolyl radical_ Heterocyclic compounds according to C¾.aim 23 , in which the group W is a phenyl, chlorophenyl , fluorophenyl, dichlorophenyl, mono-, di- or tri-methoxyphenyl , aminophenyl, nitrophenyl, di-methylphenyl, 1-naphthyl, 27naphthyl or 2-quinolyl radical. ο Heterocyclic compounds according to amy one of Claims 11 to 24, in which is hydrogen. ο Heterocyclic compounds according to any one^of Claims 2 11 to 25 , in which R is the benzoyl radical„ ο Heterocyclic compounds according to any one of Claims 11 to 26, in which represents a ring system of formula Heterocyclic compounds according to any one of Claims 11 to 26, in represents a ring system of formula /' ' g7G0l -2 H-85/95-Is* · ^ 30 β Heterocyclic compounds according to Claim 29 , in which W is a phenyl radical.

2. 31. Heterocyclic compounds according to Claim 29 or 30 , 2 m which R is -COR wherein. R is phenyl. 33 · Heterocyclic compounds according to Claim 10 , in which R2, R, X®, Acyl and the term "lower" have the meanings defined in Claim lO and A is the unsubstituted hydrazone derivative of a mono- or di-keto lower alkylcne radical.

3. 4. Heterocyclic compounds according to Claim 33 , in which the derivative A has the formula 1N. H. 83 H-85/95-Is* 55· Heterocyclic compounds according to Claim 55 or 54-» in which V is a dichlorop enyl radical«

4. 36. Heterocyclic compounds according to any one of Claims 33, 5 or 55, in which R is -COR wherein I? is phenyl, 37· Heterocyclic compounds according to any one of Claims 38„ 1- [2-( ,4—Methylenedioxyphenyl) ethyl]-4~benzamido- piperidine. 39 o 1- [2-C.o-Chlorophenyl) ethyl!- -oenzamidopiperidine . 0 „ 1- [2-(2-Naphthyloxy) ethyl]-4-benzamidopiperidine , H-85/95-fl o l-[2-(Gyclohexyl)et;hyl]- -benzamfdopiperidineo o l-[2-( 3 ,4-Dimethoxyphenyl)ethyl]-4—acetamidopyridinium iodideo o 1- [2-( 3 ,4-Dimethoxyph.enyl) ethyl]-4-acetamidopiperidine„ o 1- [2-( 3 ,4-Dimethoxyphenyl) ethyl]-4-aminopiperidirie _ o 1- [2-( 3 , 4-Dimethoxyphenyl)ethyl]-4-benzamidopiperidine0 o l-C2~( 3,4-Dimethoxyphenyl)ethyl]-4-(2-chlorobenzamido) piperidine0 o l-[2-( 3 ,4-Limethoxyphenyl) ethyl -4-piperOjiyramidopiperidine , o l-.[2-( 3,4, 5-Trimethoxyphenyl)ethyl]-4-benzamidopiperidine _ «, l- [2-( 3 ,4-Dihydroxyphenyl)ethyl]-4-benzamido.piperidine. o l-Phenacyl-4-benzamidopiperidineo o 1- [2-( 3 ,4-Dihydroxyphenyl) -2-oxoethyl]-4- benzamidopiperidinee 0 1- [2-( 1-Naphthyl) ethyl]-4-benzamidopiperidine0 o 1- [2-( 2-Naphth.ylethyl]-4-benzamidopiperidine0 o 1- [2-( 3-Indenyi) ethylJ -4-benzamidopiperidine0 o 1- [ 3-( 3-Indenyl)propyl]-4-benzamidopiperidine» o l- [2-(4-Pyridyl) ethyl]-4-benzamidopiperidine „ o l-[2-(4-Pyrimidinyl)ethyl]-4-benzamidopiperidine0 H-85/95-fl 2- yl ■ ~ 9 o l-(Pyrrol^-^-oxalyl)- -t>enzamidopiperidineo (3. 1-[2-Hydroxy-2-(2-pyrry1) ethyl]-4-benzamidopiperidineβ 1» l-C3-(l-Phenyl-5-methylpyrazol-4-yl)-3-oxo-propyl]- 4-benzamido-piperidine0 2„ l~[2-(3-Benzo[b]thienyl) ethyl]-4—benzamidopiperidineo 3„ 1-[2-(2-Quinolyl)ethyl]-4-benzamidopiperidine„ 4·,, l-[N-( 5-Ethoxycar.bonyl-4-phenylthiazol-2-yl) carbamoylmethyl]-4-benzamidopiperidine 0 5„ l-[N-(2-riethylphenyl)carbamoylethyl]-4-benzamidopiperidine0 6o l-[4-(N-Propionyl-N-[2,6-dichlorophenyl]amino) but-2- yn-l-yl]-4-benzamidopiperidine., 7o l-[l~(4-Acetamidophenoxy)-2-hydroxyprop-3-yl]-4- benzamidopiperidine0 8 o l-(5-Acetamido-2-hydroxybenzyl)-4-benzamidopiperidine. 9 β 1-[4-(4-Fluorophenyl)-4-oxobutyl]-4-benzamidopiperidine . 0 o 1-[2-(3-Benz[g]indolyl) ethyl]-4-benzamidopiperidine_ 1o l-[2-(2-Pyridyl) ethyl]-4-benzamidopiperidine 0 „ l-(2-Hydroxy-2-phenylethyl)-4-benzamidopiperidine„ 3 o 1-[2-( 5-Phenylthien-2-yl) ethyl]-4-benzamidopiperidine „ 4„ l-[2-(2-Benzimidazcilyl) ethyl] -4-benzamidopiperidine „ 5 o 1-[3-(1-Naphthoxy)-2-hydroxyprop-l-yl]-4- benzamidopiperidine<, 6p l-[2-(p-Nitrophenyl) ethyl]-4-be.nzamidopiperidine0 H-85/95-fl 77 ο l-[2-(p-Aminophei^l)ethyl]« ~benztiaiidopiperidineo 79ο l-[2-Phen,ethyl]-4-benzamidopyridinium bromide0 1,2 80 ο ' l-Phenethyl-4"-benzamido-^,^,5,6--tetrahydropyridine, 81ο l-[2-( -[p-Chlorophenyl]-2~phenylthiazol-5-yl)ethyl]-it~ benzamido-piperidine0 benzamidopiperidine <, 83 o 1- [2-(p-Chlorophenyl)ethyl/^-^-benzamidopiperidine» 84e l-[2-(2,6-Dichlorophenyl)ethyl]-4-benzamidopiperidineo p-Phenylprop-2-yl) 85 o l-tt^^et^^-^-benz midopiperidi e hydrochlorideo o 86 o - l-[2-()-Nitr phenyl)ethyl]-4-benzamidopiperidine 0 benzoyl 87 o l-[( 3,4-Mchloi¾li «i^)methyl]- -benzamidopiperidine. 88 o 1- [2-(o-Aminophenyl) ethyl]-4-benzamidopiperidine0 89o l-[2-(3, -Dichlorophenyl)-2-hydroxyethyl]-it- · benzamidopiperidine„ 90o l-C2-( 3 ,4-Dichlorophenyl)-2-hydrasonoethyl]-4- benzamidopiperidineβ 91 o 1- [2-( 3 ,4-Dichlorophenyl) ethyl]-4-benzamidopiperidine. 92o l-( 3-Phenylpropyl)-4-benzamidopiperidine . 93 o 1- [4-

5. 97. 1-[4-( 2 , 5-Dimethylphenyl)-4-oxobutyl]-4- benzamidopiperidine„ 98 β 1-[4-( 2 ,4-Dimethylphenyl)-4-oxobutyl]-4-benzamidopiperidine. 99c l-(4-Phenylbutyl)-4~benzamidopiperidine<> 100 o l-( 3,4-Methylenedioxybenzyl)-4-benzamidopiperidine„ 101ο l-[2-(p-Methoxyphenyl)ethyl]-—benzamidopiperidine. 102 o N-Phenyl- -( -benzamidopiperid-l-rvyl)butyramideo 103 o 2-( -Benzamidopiperid-l-yl)methylbenzo-l, -dioxano 104 „ l-[ -(p-Shlorophenyl)-i- -ox0.butyl]-4-benzamidopiperidineo 105o l-( 2-Phenoxyethyl)-4-benzamidopiperidine0 106 o l-(4-Phenyl-4-hydroxybutyl)-4-benzamidopiperidineo 107o 1~[ -(p-Fluorbphenyl)-4-hydroxybutyl]-4-benzamidbpiperidine„ 108c l-[3-(l-Naphtbyloxy)propyl]-4-behzamidopiperidineo 109 o l-C2-(l,2,3,4-Tetrahydro-6-napnSinyl)-2-oxoetliyl]-4- benzamido-piperidineo

6. 110. 1- C2-( 1 , 2 , 3 ,4-Tetrahydro-6-naphthyl) -2-hydroxyethyl]-4- benzamidopiperidine0

7. 111. 1- C4-(I , 2 , 3 ,4-Tetr hydro-6-naphthyl)-4-oxobutyl]-4- benzamidopiperidine, 112,, The acid addition and quaternary ammonium salts of the compounds according to any one of Claims 41, 43, to 78 and 80 to 840 760 1 - 2 H-85/95-Is* A pharmaceutical composition according to Claim 1, which comprises a heterocyclic compound according to any one of Claims 11 to 31 wherein W, A, R1, Acyl and the term "lower" are as defined in any one of Claims 11 to 31; the ring system is a ring system of formula 11(b) or 11(c) as shown in Claim 10; and R is the group -COR wherein R is as defined in Claim 1 or according to any one of Claims 1, 43, 45 to 78, 80 to 85 and 112„ 11 o A pharmaceutical composition according to Claim 1, which comprises a heterocyclic compound according to any one of Claims 10, and 32 to 40, wherein n, W, A, Acyl and the term "lower" are as defined in one of Claims 10 and 32 to 40; the ring system is a ring system of formula II(t>) or 11(c) as shown 2 in Claim 10; and R is the group -COR wherein R is as defined in Claim 1 or according to any one of Claims 86 to 111 and 113» 116o A process for the preparation of a compound of formula (I) as claimed in Claim 11 wherein V, R1, R, X®, A, Acyl and the term "lower" have the meanings defined in Claim 11 and R is the -COR group, in which process a compound of general formula 111(a) 111(b) III(c) 37β01 -2 H-85/95-Is* is reacted with an alkylating or acylating agent of the general formula [W]-A-Y (IV) (in which formulae W, R, and A have the meanings defined above and Y is a halogen atom or an equivalent replaceable atom or radical, Y being the radical X when a compound of formula III(a) is used. A process according to Claim 116, in which Y is a halogen atom selected from chlorine and bromine<> A process for the preparation of a compound of formula (I) as Claimed in Claim 11 wherein represents a ring system of formula 11(b) or 11(c) as shown in Claim 10, R 2 is the -COR group, W, R, R1 and the term "lower" have the meaning defined in Claim 11, and A is a hydroxy-lower alkylene or radical, in which process a compound of formula [Wl-A^H (V) (in which w* has the meaning defined above and A"*" is an epoxy-substituted lower alkylene radical or a -O-CHg.C ΛH-CH-radical is reacted with a compound of formula 111(b) or III(c) as shown in Claim 116 wherein R"*" and R are as hereinabove definedβ A process for the preparation of a compound of formula (I) as claimed in Claim 11 wherein represents a ring system of formula 11(b) or 11(c) as shown in Claim 10, R 2 is the -COR group, W, R, R1 and 37601-2 H-85/95-ls* - and A is a lower alkylene radical, in which process a compound of formula [W3-B (VII) (wherein A has the meaning defined above and B is a straight or branched chain alkenyl residue) is reacted with a compound of formula 111(b) or III(c) as shown in Claim 116 wherein R and R^ are as hereinabove defined,, A process for the preparation of a compound of formula (I) as claimed in Claim 11 wherein system of in Claim 10, and W, R, R1, X®, A, Acyl and the term "lower" have 2 the meanings defined in Claim 11 and R is the -COR group, in which process a compound of general formulia (I) in which A, Acyl and the term "lower" have the meanings defined above and R 2 is a hydrogen atom, is acylated with either (i) a reactive derivative or an acid of general formula RoCOOH (wherein R is as defined above other than lower alkoxy, or (ii) a haloester of formula Hal.CO.R (wherein Hal is a halogen atom and R is lower alkoxy. A process for the preparation of a compound of formula (I) as claimed in Claim 11 wherein s a ring system of formula 11(a) or in Claim 10, and W, R , 7601 -2 H-85/95-Is as defined in connection with formula RCOOH in Claim 120, in which process an acid of formula R o COOH wherein R is as hereinabove defined is the term "lower" have the meanings defined above and R is hydrogen (i) in the presence of a known condensing agent, or (II) by first activating the amino function of the compound of general formula (I) by known methods . A process for the preparation of a compound of formula (I) as claimed in Claim 11, wherein W, R, R Acyl and the t ave the meanings defined in Claim 11 represents a ring system of formula 11(b) or 11(c) as shown in Claim 10, 2 R is the -COR group, and A is a lower alkylene or a mono- or di-keto lower alkylene radical or a bivalent radical of the formula -iTo CH eC=C0 CIIp- , which process Acyl comprises a Mannich reaction using a compound of formula 111(b) or III(c) as shown in Claim 116 wherein R^ and R are as hereinabove defined as secondary amine, formaldehyde and a suitable reactive derivative of the radical W in which the chain A has been partially formed and which partially formed chain contains a site of the type known to participate in the riannich reaction, A process for the preparation of a compound of general formula (I) as claimed in Claim 11, wherein H-85/95-Is represents a ring system of formula 11(b) or 11(c) as shown in Claim 10, R is the -COR group, and W, R, R1, A, Acyl and the term "lower" have the meanings defined in Claim 11, in which process a compound of formula XI(a) XI(b) (wherein A, R1 and R have the meanings defined above and T is a known precursor group of ) , is reacted with another molecule of the type known in the literature for the conversion of the precursor group T to \h 12 o A process for the preparation of a compound formula (I) as claimed in Claim 11, wherein is a ring system of formula 11(a) or 11(c) as shown in Claim 10, and W, R1, X®, A, Acyl and the term "lower" have the meanings defined in Claim 11 and-R is a hydrogen atom, in which process a corresponding compound of formula (wherein A, A, and R1 have the meanings defined above, represents a ring system of formula H-85/95-Is* XIII(a) XIII(c) and Z is a protecting group known in the art for the protection of the amino function) is subjected to a reaction known in the art for the removal of the protecting group0 A process for the preparation of a compound formula (I) as claimed in Claim 10, wherein W, R1, R, ^, Acyl and the term" lower" have meanings defined in Claim 10, R is the -COR group and A is a bivalent radical of formula -NH.C0o(CH2) in which process a compound of general formula Ill(a) Ill(b) III(c) wherein R and R1 are as defined in Claim 10, is reacted with an alkylating or acylating agent of the general formula [W3-A-Y (17) (wherein W and A have the meanings defined immediately above and Y is a halogen atom or an equivalent replaceable atom or radical5 Y being the radical X when a compound of formula III(a) is used. H-85/95-Is* A process for the preparation of a compound of formula (I) as claimed in Claim 10, wherein a rin¾ system of formula II( or 11(c) as shown in Claim 10, and W, R, R1, X®, Acyl and the term" lower" have the meanings defined in Claim 10, R is the -COR group and A is the bivalent radical of formula - H„C0„(CH2)^-, in which process a compound of general formula (I) in which the term "lower" have the meanings defined immediately 2 above and R is a hydrogen atom, is acylated with either (i) a reactive derivative of an acid of general formula R.COOH (wherein R is as defined above other than lower alkoxy) , or (ii) a haloester of formula Halo CO „R (wherein Hal is a halogen atom and R is lower alkoxy) » 12 .. A process for the preparation of a (I) as claimed in Claim 10 wherein is a ring system of formula 11(a) or 11(c), as shown in Claim 10, and W, R1, X®, Acyl and the term"lower" 2 have the meanings defined in Claim 10, R is the -COR group, wherein R is as defined in connection with formula RoC00H in Claim 126 and A is the bivalent radical -NH.CO.iCHg) in which process an acid of formula RoC00H, wherein R is as hereinabove defined, is reacted with a compound of general formula (I) in which w> r1» A> - 2% - H-85/95-Is* v.- and the term "lower" have the meanings defined immediately above and R is hydrogen (i) in the presence of a known condensing agent or (ii) by first activating the amino function of the compound of general formula (I) by known methods 0 A process for the preparation of a compound of general formula (I) as claimed in Claim 10, wherein is a ring system of formula 11(a) or 11(c as shown in Claim 10 and W, R1, X®, Acyl and the term "lower" have the meanings defined in Claim 10, R is hydrogen atom and A is the bivalent radical -NHoCOo (CI^ , in which -process a corresponding compound of formula (wherein W, A and R have the meanings defined immediately above , represents a ring system of formula wherein R and are as defined in Claim 10 and Z is a protecting group known in the art for the protection of the amino function) is subjected to a H-85/95 reaction known in the art for the removal of the protecting group„ A process for the preparation of compounds of gener I) as claimed in Claim 10, wherein represents a ring system of formu 11(b) or 11(c) as shown in Claim 10, V, R"1", R^, R, ®, and the term "lower" have the meanings defined in Claim 10 and A is a bivalent radical of the formula -NHoC0o (CIL,) - wherein n is 1, 2 or 3, in which process a reactive derivative of an acid of formula is reacted with a primary amine of formula [W]-NH2 (XV) (in which formulae .i^^^1^2 w» T^ » Γι2> β» n and the term" lower" have the meanings defined immediately above) β A process for formula (I) as represents a ring system of general formula 11(b) or 11(c) as shown in Claim 10, R is the -COR group wherein R is as defined in Claim 10, A is a lower alkylene radical or the bivalent radical -NH.CO.iCHg) -wherein n is 1, 2 or 3» and , "lower" and Έ?~ have the meanings defined in Claim 10, in which process a compound of the general formula L « J Oil (XVI) (in which W and A have the meanings defined immediately above) is reacted with a compound of the general formulaHI(b) orHI(c) as shown in Claim 125 wherein R and R^" are as hereinabove definedo A process for the preparation of compounds of general formula (I) as claimed in Claim 10, system of formula II(b.) or 11(c) as shown in Claim 10, W and R 1 have ttie meanings defined in Claim 10, R2 is the -COR group wherein R has the meanings defined in Claim 10 and A is a mono-keto lower alkylene radical of formula -CO.iCHg - in which m is 1 to 59 in which process a compound of formula [Wl-H (XVII) is acylated with an acid halide of formula (wherein V, - ^^^™2 H 321(1 m have the meanings defined immediately above and Hal is a halo en atom) 0 H-85/95-Is" 132 o A process according to any one of Claims 116, 117 » 120 , 121 and 124, in which a compound of formula (I) is produced in which represents a ring system of formula 11(a) as defined in Claim 10 , and this compound is reduced to the corresponding compound in which represents a ring system of formula 11(b) or 11(c) as defined in Claim 10. 133 » A process according to any one of Claims 125 to 128, in which a compound of formula (I) is produced in which represents a ring system of formula 11(a) as defined in Claim 10 , and this compound is reduced to the corresponding compound in which system of formula 13 » A process according to any one of Claims 116, 117 and I32 , in of formula (I) is produced in which represents a ring system of formula 11(b) as defined in Claim 10 , and this compound is reduced to the corresponding compound in which - — HR2 represents a ring system of formula 11(c) as defined in Claim 10. A process accoding to any one of Claims 125 , 129 to 131 and 133 in which a compound of formula (I) is produced in which represents a ring system of formula 11(b) as defined in Claim 10, and this compound 760 H-85/95-Is* ich

8. 136. A process according to any one of Claims 116, 117 , 120 to 124·, 132 and 13 » in which a compound of formula (I) is produced in which A is a mono- or di-keto lower alkylene radical, and this compound is reduced to one in which A contains one or two hydroxyl groupso 137 o process according to any one of Claims 116, 117 , 120 to 12 and 132, in which a compound of formula (I) is produced in which A is a mono- or di-keto lower alkylene radical and this compound is reduced to one in which the keto group/'groups has/have been replaced by one or two methylene groups0

9. 138. A process according to any one of Claims 116, 117 » 120 to 124, 131 , 13 and 134» in which a compound of formula (I) is produced in which A is a mono- or di-keto lower alkylene radical, and this compound is converted into the unsubstituted hydrazone derivative thereof. 139 · A process according to any one of Claims 116 to 123 , or any one of Claims 132 , 134, 136 and 137 all as dependent on any one of Claims 116, 117 , 120 and 121 , in which a compound of formula (I) is produced in which of formula 11(a) or s the -COR group, and this compound is hydrolysed to the corresponding compound of formula (I) in which R is 37601 -8 H-85/95-Is* * hydrogen, which in turn may "be further reacted to give a compound of formula (I) in which R is a different -COR group„ 14-0. A process according to any one of Claims 125 to 127 , 129 , 130 and 131 , or any one of Claims 133 and 135 , both as dependent on any one of Claims 125 to 127 and 129 in which in which formula 11(a) or 11(c) as shown in Claim 1 and R is the -COR group, and this compound is hydrolysed to the corresponding compound of formula (I) in which 2 R is hydrogen, which in turn may be further reacted 2 to give a compound of formula (I) in which R is a different -CCR group.

10. 141. A process according to any one of Claims 1] 6 to 124, 13 , 134-j 136, 137 and' 1399 in which a compound of formula (I) is produced in which the radical W is substituted by one or more methoxy groups, and this compound is hydrolysed to the corresponding compound containing one or more hydroxyl groups.

11. 142. A process according to any one of Claims 125 to 131 » 133 , 135 and 140, in which a compound of formula (I) is produced in which the radical is substituted by one or more methoxy groups , and this compound is hydrolysed to the corresponding compound containing one or more hydroxyl groups. H-85/95-Is*

12. 143. A process according to any one of Claims 116 to 124, 132, 134-, 136, 137, 139 and 141 , in which a compound of formula (I) is produced in which the radical W is substituted "by a nitro group, and this compound is reduced to the corresponding amino compound, which in turn may he further alkylated or acylatedo 144o A process according to any one of Claims 125 "to 131* 133 j 135, 1 0 and 142, in which a compound of formula (I) is produced in which the radical W is substituted by a nitro group, and this compound is reduced to the corresponding amino compound, which in turn may be further alkylated or acylatedo

13. 145. A process according to any one of Claims 116, 117» 119 to 124, 132, I34, 137, 139, 1 1 and 143, in which A in the compound produced is a lower alkylene radical. 146 o A process according to Claim 145 , in which the lower alkylene radical is an ethylene radical.

14. . A process according to Claim 130, or any one of Claims 140, 142 and 144 all as dependent on Claim 130, in which A in the compound produced is a lower alkylene radical. 148.. A process according to Claim 147, n which the lower alkylene radical is an ethylene radical. 149. A process according to any one of Claims 116, 117 and 120 to 124 or any one of Claims 139, 141 and 143 all a' dependent on any one of Claims 116, 117 and 120 tol23 in which A in the compound produced is a mono- or di-keto lower alkylene radical. 37601-2 H-85/95-Is* 150ο A process according to Claim 1 9, in which A is a mono-keto lower alkylene radical of formula 1 1 o A process according to any one of Claims 116 to 118, 120, 121, 123, 124. 132, 134 and 136 or any one of Claims 139, 141 and 143 all as dependent on any one of Claims 116 to 118, 120, 121, 123, 124, 132, 134 and 136 in which A in the compound produced is a hydroxy lower alkylene radicalβ 152 o A process according to Claim 151, in which the hydroxy lower alkylene radical has the formula -CH.CiLj- or OH 153· A process according to any one of Claims 116, 117, 120, 121, 123, 124, 132 and 134 or any one of Claims 139, 141 and 143 all as dependent on any one of Claims 116, 117, 120, 121, 123, 124, 132 and 134, in which A in the compound produced is an -0-(lower alkylene)- radical. 154,» A process according to Claim 153, which the -0-(lower alkylene)-radical is of formula or -0-(CH2)5-. 155 o A process according to any one of Claims 116, 117, 120, 121, 123, 124, 132 and 134, or any one of Claims 139, 141 and 143 all as dependent on any one of Claims 116, 117, 120, 121, 123, 124, 132 and 134 in which A in the compound prepared is of formula or -NHoC0„(CH2)2-o 37-601 «S H-85/95-ls* 156.. A process according to any one of Claims 125 to 128 or Claim 133 as dependent on any one of Claims 125 to 128, or any one of Claims 135 , 10, 142 and 144 all as dependent on any one of Claims 125 to 127 in which A in the compound prepared is of formula -Nil.CO „ (CI^) „ 157 ·. A process according to Claims 129 or 130 , in which A in the compound prepared is of formula - H.CO. wherein n is 1, 2 or 3· 158,. A process according to any one of Claims 116 to 123 or any one of Claims 132, 134, 136, 137 , 139 , 141, i^-3,145, 146 and 149 to 155 all as dependent on any one of Claims 116, 117 and 120 to 123 , in which R in the compound prepared is the -COR group wherein R is as defined in Claim 10.

15. O A process according to Claim 158 , in which the -COR group is the benzoyl group. 160. A process according to any one of Claims 125 to 127, 129 , 130, 131, 138, 147, 148 and 157 or any one of Claims 133 , 135, 140, 142, 144 and 156 all as dependent 2 on any one of Claims 125 to 127 and 129 in which R in the compound prepared is the -COR group wherein R is as defined in Claim 10. 161. A process according to Claim 160, in which the -COR group is the benzoyl group. 162. A process according to any one of Claims 116 to 124, 132, 134, 136, 137 , 139 , 141, 143, 145, 146, 149, 155 , 158 and 159 , in which in the compound prepared is a phenyl, mono- or di-halophenyl , mono, di- or tri-lower 8760ί -2 H-85/95-Is*f alkoxy-phenyl , mono- or di-hydroxyphenyl, naphthyl, pyridyl, pyrimidinyl, quinolyl, mono- or di-lower alkylphenyl, benzCgJindolyl, nitrophenyl, aminophenyl acylaminophenyl or methylendioxyphenyl radical. 16.5 o A process according to Claim 162 , in which W is a phenyl, chloro-, bromo- or fluoro-phenyl , dichlorophenyl, methylphenyl, dimethylphenyl, mono-, di- or tri- methoxyphenylqnaphth-l-yl, naphth-2-yl or q inol-2-yl radical. 16 ο A process according to any one of Claims 125 to ljl, 133 , 135 , 138 , 140 , 142 , 144, 147 , 148 , 156 ,. 157 , 160 and 161 , in which V in the compound prepared is a phenyl, mono- or di-halophenyl , mono-, di- or tri-lower alkoxyphenyl , mono- or di-hydroxyphenyl, naphthyl, pyrridyl, pyrimidinyl, quinolyl, mono- or di-lower alkylphenyl, benzCgJindolyl, nitrophenyl, aminophenyl, acylaminophenyl methylenedioxy phenyl, benzo-1 ,4- dioxanyl, or tetrahydronaphthyl radical .

16. , o A process according to Claim 164, in which W is a phenyl, chloro-, bromo- or fluoro-phenyl, dichlorophenyl, methylphenyl, dimethylphenyl, mono-, di- or tri- methoxyphenyl , naphth-l-yl, naphth-2-yl or quinol-2-yl radical. 166. A process according to any one of Claims 116 to 124 , 132 , 134 , 136 , 137 , 139 , 141 , 143 , 145 , 146 , 149 , 155, 158 , 159 , 162 and 163 substantially as described herein and shown with reference to any one of Examples 1 to 43. - 8 ^- 37601-2 H-85/95-Is* 167» A process according to any one of Claims 125 to 131» 133 , 135 , 138, 140, 142, 144, 147, 148, 156, 157 , 160, 161, 164 and 165 substantially as described herein and shown with reference to any of Examples 50 to 77 and 80. 168. Heterocyclic compounds according to Claim 11 when prepared by the process claimed in any of Claims 116 to 124, 132 , 134, 136, 137 , 139 , 14-1, 14-3 , 145, 146, 149, 155 , 158 , 159 , 162, 163 and 166. 169 · Heterocyclic compounds according to Claim 10 when prepared by the process claimed in any of Claims 125 to 131 , 133 , 135 , 138, 140, 142, 144, 147, 148, 156 , 157 , 160, 161, 164, 165 and 167. I 0. Compounds according to Claim 11 substantially as described herein and shown with reference to any one of Examples 1 to 43. 1 1 Compounds according to Claim 10 substantially as described herein and shown with reference to any one of Examples 50 to 77 and 80.

17. . Compounds according to Claim 10 substantially as described herein and shown with reference to any one of Examples 81 to 106.