IL330083A - Compositions and methods for inhibiting expression of inhibin subunit beta e (inhbe) - Google Patents
Compositions and methods for inhibiting expression of inhibin subunit beta e (inhbe)Info
- Publication number
- IL330083A IL330083A IL330083A IL33008326A IL330083A IL 330083 A IL330083 A IL 330083A IL 330083 A IL330083 A IL 330083A IL 33008326 A IL33008326 A IL 33008326A IL 330083 A IL330083 A IL 330083A
- Authority
- IL
- Israel
- Prior art keywords
- inhbe
- compositions
- methods
- inhibiting expression
- subunit beta
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/343—Spatial arrangement of the modifications having patterns, e.g. ==--==--==--
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/10—Applications; Uses in screening processes
- C12N2320/11—Applications; Uses in screening processes for the determination of target sites, i.e. of active nucleic acids
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2023140636 | 2023-12-21 | ||
| PCT/CN2024/140813 WO2025131019A1 (en) | 2023-12-21 | 2024-12-20 | Compositions and methods for inhibiting expression of inhibin subunit beta e (inhbe) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL330083A true IL330083A (en) | 2026-08-01 |
Family
ID=96136461
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL330083A IL330083A (en) | 2023-12-21 | 2024-12-20 | Compositions and methods for inhibiting expression of inhibin subunit beta e (inhbe) |
Country Status (5)
| Country | Link |
|---|---|
| CN (1) | CN122477283A (en) |
| AU (1) | AU2024404570A1 (en) |
| IL (1) | IL330083A (en) |
| TW (1) | TW202525307A (en) |
| WO (1) | WO2025131019A1 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2026006275A2 (en) * | 2024-06-26 | 2026-01-02 | Amgen Inc. | Rnai constructs and methods for inhibiting expression of inhbe |
| CN121780538A (en) * | 2026-03-06 | 2026-04-03 | 北京悦康科创医药科技股份有限公司 | Double-stranded ribonucleic acid for reducing inhibin subunit beta E gene expression, and modifier and application thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050124566A1 (en) * | 2001-05-18 | 2005-06-09 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of myostatin gene expression using short interfering nucleic acid (siNA) |
| CN116761616A (en) * | 2021-01-22 | 2023-09-15 | 阿耐拉姆制药公司 | Modified double-stranded oligonucleotide |
| IL309897A (en) * | 2021-07-21 | 2024-03-01 | Alnylam Pharmaceuticals Inc | Metabolic disorder-associated target gene irna compositions and methods of use thereof |
| JP2024535888A (en) * | 2021-09-20 | 2024-10-02 | アルナイラム ファーマシューティカルズ, インコーポレイテッド | Inhibin subunit beta E (INHBE) modulator compositions and methods of use thereof |
| AU2024233116A1 (en) * | 2023-03-09 | 2025-09-18 | Basecure Therapeutics Llc | Compositions and methods for inhibition of expression of inhibin subunit beta e (inhbe) genes |
-
2024
- 2024-12-20 IL IL330083A patent/IL330083A/en unknown
- 2024-12-20 TW TW113149772A patent/TW202525307A/en unknown
- 2024-12-20 CN CN202480079376.8A patent/CN122477283A/en active Pending
- 2024-12-20 AU AU2024404570A patent/AU2024404570A1/en active Pending
- 2024-12-20 WO PCT/CN2024/140813 patent/WO2025131019A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| TW202525307A (en) | 2025-07-01 |
| CN122477283A (en) | 2026-07-28 |
| AU2024404570A1 (en) | 2026-07-30 |
| WO2025131019A1 (en) | 2025-06-26 |