IL326926A - Compositions and methods of use thereof for treating neurodegenerative and mitochondrial diseases - Google Patents
Compositions and methods of use thereof for treating neurodegenerative and mitochondrial diseasesInfo
- Publication number
- IL326926A IL326926A IL326926A IL32692626A IL326926A IL 326926 A IL326926 A IL 326926A IL 326926 A IL326926 A IL 326926A IL 32692626 A IL32692626 A IL 32692626A IL 326926 A IL326926 A IL 326926A
- Authority
- IL
- Israel
- Prior art keywords
- pct
- compound
- alkyl
- administration
- heterocycle
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5076—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving cell organelles, e.g. Golgi complex, endoplasmic reticulum
- G01N33/5079—Mitochondria
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Toxicology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Food Science & Technology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202062980143P | 2020-02-21 | 2020-02-21 | |
| PCT/US2021/019113 WO2021168446A1 (en) | 2020-02-21 | 2021-02-22 | Compositions and methods of using the same for treatment of neurodegenerative and mitochondrial disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL326926A true IL326926A (en) | 2026-05-01 |
Family
ID=77391353
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL326926A IL326926A (en) | 2020-02-21 | 2021-02-22 | Compositions and methods of use thereof for treating neurodegenerative and mitochondrial diseases |
| IL295681A IL295681B2 (en) | 2020-02-21 | 2022-08-16 | Compositions and methods of use thereof for treating neurodegenerative and mitochondrial diseases |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL295681A IL295681B2 (en) | 2020-02-21 | 2022-08-16 | Compositions and methods of use thereof for treating neurodegenerative and mitochondrial diseases |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20240018146A1 (enExample) |
| EP (1) | EP4106874A4 (enExample) |
| JP (3) | JP2023515101A (enExample) |
| KR (2) | KR20220158290A (enExample) |
| CN (1) | CN115515682B (enExample) |
| AU (1) | AU2021222053A1 (enExample) |
| BR (1) | BR112022016614A2 (enExample) |
| CA (1) | CA3168531A1 (enExample) |
| CO (1) | CO2022013603A2 (enExample) |
| CR (1) | CR20220476A (enExample) |
| EC (1) | ECSP22074210A (enExample) |
| IL (2) | IL326926A (enExample) |
| MX (2) | MX2022010309A (enExample) |
| PH (1) | PH12022552518A1 (enExample) |
| WO (1) | WO2021168446A1 (enExample) |
| ZA (1) | ZA202210409B (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3947390A4 (en) * | 2019-04-03 | 2022-11-30 | Mitokinin, Inc. | COMPOSITIONS AND METHODS FOR THEIR USE FOR THE TREATMENT OF NEURODEGENERATIVE AND MITOCHONDRIAL DISEASE |
| CN119752781B (zh) * | 2025-03-04 | 2025-07-01 | 中国农业大学 | 缓解成熟卵子老化的组合物、培养液、产品及方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9604361D0 (en) * | 1996-02-29 | 1996-05-01 | Pharmacia Spa | 4-Substituted pyrrolopyrimidine compounds as tyrosine kinase inhibitors |
| TW200508224A (en) * | 2003-02-12 | 2005-03-01 | Bristol Myers Squibb Co | Cyclic derivatives as modulators of chemokine receptor activity |
| HRP20120786T1 (hr) * | 2006-02-02 | 2012-11-30 | Millennium Pharmaceuticals, Inc. | Inhibitori aktivirajuä†eg enzima e1 |
| SG174772A1 (en) * | 2006-09-11 | 2011-10-28 | Curis Inc | Multi-functional small molecules as anti-proliferative agents |
| EP2342178B1 (en) * | 2008-09-02 | 2016-09-28 | Sanofi | Substituted aminoindanes and analogs thereof, and the pharmaceutical use thereof |
| AU2014214561C1 (en) * | 2013-02-11 | 2019-01-17 | Mitokinin, Inc. | Compositions and methods for treating neurodegenerative diseases |
| WO2018237145A1 (en) * | 2017-06-21 | 2018-12-27 | Mitokinin, Inc. | Compositions and methods using the same for treatment of neurodegenerative and mitochondrial disease |
-
2021
- 2021-02-22 KR KR1020227032526A patent/KR20220158290A/ko active Pending
- 2021-02-22 US US17/801,450 patent/US20240018146A1/en active Pending
- 2021-02-22 CN CN202180025593.5A patent/CN115515682B/zh active Active
- 2021-02-22 WO PCT/US2021/019113 patent/WO2021168446A1/en not_active Ceased
- 2021-02-22 CR CR20220476A patent/CR20220476A/es unknown
- 2021-02-22 MX MX2022010309A patent/MX2022010309A/es unknown
- 2021-02-22 IL IL326926A patent/IL326926A/en unknown
- 2021-02-22 KR KR1020267019334A patent/KR20260098022A/ko active Pending
- 2021-02-22 BR BR112022016614A patent/BR112022016614A2/pt unknown
- 2021-02-22 EP EP21757063.9A patent/EP4106874A4/en active Pending
- 2021-02-22 JP JP2022550119A patent/JP2023515101A/ja not_active Withdrawn
- 2021-02-22 AU AU2021222053A patent/AU2021222053A1/en active Pending
- 2021-02-22 CA CA3168531A patent/CA3168531A1/en active Pending
- 2021-02-22 PH PH1/2022/552518A patent/PH12022552518A1/en unknown
-
2022
- 2022-08-16 IL IL295681A patent/IL295681B2/en unknown
- 2022-08-19 MX MX2026003961A patent/MX2026003961A/es unknown
- 2022-09-20 ZA ZA2022/10409A patent/ZA202210409B/en unknown
- 2022-09-21 EC ECSENADI202274210A patent/ECSP22074210A/es unknown
- 2022-09-21 CO CONC2022/0013603A patent/CO2022013603A2/es unknown
-
2025
- 2025-05-09 JP JP2025078577A patent/JP7808226B2/ja active Active
-
2026
- 2026-01-16 JP JP2026005770A patent/JP2026067907A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2021168446A1 (en) | 2021-08-26 |
| IL295681B2 (en) | 2026-08-01 |
| EP4106874A4 (en) | 2024-03-20 |
| JP2023515101A (ja) | 2023-04-12 |
| MX2022010309A (es) | 2022-11-14 |
| CN115515682B (zh) | 2024-06-21 |
| IL295681A (en) | 2022-10-01 |
| JP7808226B2 (ja) | 2026-01-28 |
| PH12022552518A1 (en) | 2024-03-11 |
| CN115515682A (zh) | 2022-12-23 |
| JP2026067907A (ja) | 2026-04-21 |
| JP2025142197A (ja) | 2025-09-30 |
| CO2022013603A2 (es) | 2023-03-17 |
| BR112022016614A2 (pt) | 2022-12-13 |
| IL295681B1 (en) | 2026-04-01 |
| EP4106874A1 (en) | 2022-12-28 |
| KR20220158290A (ko) | 2022-11-30 |
| CA3168531A1 (en) | 2021-08-26 |
| CR20220476A (es) | 2023-05-31 |
| KR20260098022A (ko) | 2026-06-25 |
| US20240018146A1 (en) | 2024-01-18 |
| AU2021222053A1 (en) | 2022-09-15 |
| MX2026003961A (es) | 2026-05-04 |
| ZA202210409B (en) | 2024-01-31 |
| ECSP22074210A (es) | 2023-02-28 |
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