IL326691A - מעכבים של klk5 הטרוארומטיים טריציקליים - Google Patents

מעכבים של klk5 הטרוארומטיים טריציקליים

Info

Publication number
IL326691A
IL326691A IL326691A IL32669126A IL326691A IL 326691 A IL326691 A IL 326691A IL 326691 A IL326691 A IL 326691A IL 32669126 A IL32669126 A IL 32669126A IL 326691 A IL326691 A IL 326691A
Authority
IL
Israel
Prior art keywords
compound
pct
alkyl
ring
cycloalkyl
Prior art date
Application number
IL326691A
Other languages
English (en)
Original Assignee
Biocryst Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocryst Pharm Inc filed Critical Biocryst Pharm Inc
Publication of IL326691A publication Critical patent/IL326691A/he

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/86—Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/91—Dibenzofurans; Hydrogenated dibenzofurans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
IL326691A 2023-08-25 2024-08-23 מעכבים של klk5 הטרוארומטיים טריציקליים IL326691A (he)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202363534700P 2023-08-25 2023-08-25
PCT/US2024/043684 WO2025049326A1 (en) 2023-08-25 2024-08-23 Tricyclic heteroaromatic inhibitors of klk5

Publications (1)

Publication Number Publication Date
IL326691A true IL326691A (he) 2026-04-01

Family

ID=94820168

Family Applications (1)

Application Number Title Priority Date Filing Date
IL326691A IL326691A (he) 2023-08-25 2024-08-23 מעכבים של klk5 הטרוארומטיים טריציקליים

Country Status (12)

Country Link
EP (1) EP4766361A1 (he)
KR (1) KR20260078913A (he)
CN (1) CN122070129A (he)
AR (1) AR133636A1 (he)
AU (1) AU2024334241A1 (he)
CL (1) CL2026000528A1 (he)
CO (1) CO2026003594A2 (he)
IL (1) IL326691A (he)
MX (1) MX2026002224A (he)
TW (1) TW202523671A (he)
UY (1) UY40870A (he)
WO (1) WO2025049326A1 (he)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003086404A1 (en) * 2002-04-08 2003-10-23 Merck & Co., Inc. Fused quinoxaline derivatives as inhibitors of akt activity
WO2013167582A1 (en) * 2012-05-09 2013-11-14 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for prevention or treatment of chronic obstructive pulmonary disease
CN115335046A (zh) * 2020-03-25 2022-11-11 思研(Sri)国际顾问与咨询公司 脂肪氧合酶抑制剂

Also Published As

Publication number Publication date
TW202523671A (zh) 2025-06-16
MX2026002224A (es) 2026-06-01
CN122070129A (zh) 2026-05-19
CO2026003594A2 (es) 2026-04-16
AU2024334241A1 (en) 2026-03-26
UY40870A (es) 2025-03-14
KR20260078913A (ko) 2026-05-29
CL2026000528A1 (es) 2026-06-05
WO2025049326A1 (en) 2025-03-06
EP4766361A1 (en) 2026-07-01
AR133636A1 (es) 2025-10-15

Similar Documents

Publication Publication Date Title
IL302820B1 (he) נגזרות קרבוקסאמיד טריציקליות כמעכבי prmt5
IL289878A (he) אמידים הטרוביציקליים כמעכבים של cd38
ZA202212146B (en) Inhibitors of nek7 kinase
IL310442A (he) תרכובות הטרואריל ל fused bicyclic שימושיות כמעכבי nlrp3
GB202203976D0 (en) Tricyclic phthalazines and derivatives as sos1 inhibitors
IL308476A (he) מעכבי אינטרקציית מנין-מיל
HUE072981T2 (hu) Azakinolinok mint CD38 gátlók
SG11202101255UA (en) Diazabicyclooctanones as inhibitors of serine beta-lactamases
IL276887A (he) תולדות כרומן כמעכבי אינטראקציה tcr-nck
EP4323344A4 (en) BICYCLIC HETEROAROMATIC KLK5 INHIBITORS
GB202103774D0 (en) Detectiion of Ransomware
GB202411655D0 (en) Application of circHIF1a
CA3302937A1 (en) Tricyclic heteroaromatic inhibitors of klk5
HK40104946A (en) Bicyclic heteroaromatic inhibitors of klk5
EP4405346A4 (en) SMALL MOLECULE INHIBITORS OF TEAD-YAP
IL291368A (he) מעכב ביטוי של מטאדהרין
GB202107612D0 (en) Inhibitors of metallo-beta-lactamases
HK40106117A (en) Tricyclic compounds as inhibitors of kras
GB202203181D0 (en) Inhibitors of elF4A
HK40083546A (en) Tricyclic compounds as inhibitors of kras
HK40075448A (en) Inhibitors of sarm1
AU2020900562A0 (en) Inhibitors of necroptosis
GB202111264D0 (en) Synthesis of heterocycles
HK40088585A (en) Inhibitors of nek7 kinase
HK40108613A (en) Inhibitors of the menin-mll interaction