IL326604A - Engineered and chimeric nucleases - Google Patents

Engineered and chimeric nucleases

Info

Publication number
IL326604A
IL326604A IL326604A IL32660426A IL326604A IL 326604 A IL326604 A IL 326604A IL 326604 A IL326604 A IL 326604A IL 32660426 A IL32660426 A IL 32660426A IL 326604 A IL326604 A IL 326604A
Authority
IL
Israel
Prior art keywords
engineered
chimeric nucleases
nucleases
chimeric
Prior art date
Application number
IL326604A
Other languages
Hebrew (he)
Inventor
Brian C Thomas
Lisa Alexander
Alan Brooks
Christopher Brown
Cristina Noel Butterfield
Daniela S A Goltsman
Jyun-Liang Lin
Isabel Nocedal
Kartik Rallapalli
Morayma Temoche-Diaz
Sarah Laperriere
Leanna Monteleone
Original Assignee
Metagenomi Therapeutics Inc
Brian C Thomas
Lisa Alexander
Alan Brooks
Christopher Brown
Cristina Noel Butterfield
Daniela S A Goltsman
Lin Jyun Liang
Isabel Nocedal
Kartik Rallapalli
Temoche Diaz Morayma
Sarah Laperriere
Leanna Monteleone
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metagenomi Therapeutics Inc, Brian C Thomas, Lisa Alexander, Alan Brooks, Christopher Brown, Cristina Noel Butterfield, Daniela S A Goltsman, Lin Jyun Liang, Isabel Nocedal, Kartik Rallapalli, Temoche Diaz Morayma, Sarah Laperriere, Leanna Monteleone filed Critical Metagenomi Therapeutics Inc
Publication of IL326604A publication Critical patent/IL326604A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102—Mutagenizing nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Mycology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
IL326604A 2023-09-13 2024-09-13 Engineered and chimeric nucleases IL326604A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202363582489P 2023-09-13 2023-09-13
PCT/US2024/046782 WO2025059585A1 (en) 2023-09-13 2024-09-13 Engineered and chimeric nucleases

Publications (1)

Publication Number Publication Date
IL326604A true IL326604A (en) 2026-04-01

Family

ID=95022225

Family Applications (1)

Application Number Title Priority Date Filing Date
IL326604A IL326604A (en) 2023-09-13 2024-09-13 Engineered and chimeric nucleases

Country Status (3)

Country Link
AU (1) AU2024339645A1 (en)
IL (1) IL326604A (en)
WO (1) WO2025059585A1 (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10913941B2 (en) * 2019-02-14 2021-02-09 Metagenomi Ip Technologies, Llc Enzymes with RuvC domains
CA3205865A1 (en) * 2021-01-22 2022-07-28 Brian C. Thomas Novel engineered and chimeric nucleases
KR20240004618A (en) * 2021-04-30 2024-01-11 메타지노미, 인크. Enzymes with RUVC domains

Also Published As

Publication number Publication date
AU2024339645A1 (en) 2026-04-23
WO2025059585A1 (en) 2025-03-20

Similar Documents

Publication Publication Date Title
EP4281554A4 (en) NEW ENGINEERED AND CHIMERIC NUCLEASES
IL289612A (en) hpk1 inhibitors and uses thereof
EP4003319A4 (en) HDAC6 INHIBITORS AND USES THEREOF
IL287777A (en) engineered t cells
DK3647434T3 (en) Engineered electrode for electrobiocatalysis and method of constructing the same
EP3781821A4 (en) SYMMETRICAL TONGUE AND T-CROSS
DK4140297T3 (en) Mice with an engineered immunoglobulin lambda light chain and uses thereof
EP3805217A4 (en) ERK INHIBITOR AND USES THEREOF
EP4240362A4 (en) HPK1 DIAMINOPYRIMIDINE CARBOXAMIDE INHIBITORS
EP3880677A4 (en) ERK INHIBITOR AND USES THEREOF
EP4437094A4 (en) REPROGRAMMABLE ISCB NUCLEASES AND USES THEREOF
EP3820467A4 (en) ANTIBODY-ALK5 INHIBITOR CONJUGATES AND THEIR USE
EP4157919A4 (en) BIODEGRADABLE POLYIMIDAZOLIUMS AND OLIGOIMIDAZOLIUMS
EP3938358A4 (en) RAD51 INHIBITORS
DK4376874T3 (en) CHIMERIC TIM4 RECEPTORS AND USES THEREOF
DK4034535T3 (en) AZA-QUINOLINE COMPOUNDS AND THEIR USES
EP4394037A4 (en) Site-specific nuclease
EP4077721C0 (en) CELL-FREE DNA FRAGMENTATION AND NUCLEASES
EP4017857A4 (en) METTL16 INHIBITORS AND USES THEREOF
EP4214298C0 (en) BRIQUETTE
EP3765612A4 (en) MANIPULATED CHIMERIC GUIDE RNA AND USES THEREOF
EP4161917A4 (en) GRK2 INHIBITORS AND USES THEREOF
EP3978106A4 (en) SURFACTANT AND SURFACTANT COMPOSITION
EP3997845A4 (en) CROSS REFERENCE AND RELATED APPLICATIONS
EP4441210A4 (en) MANIPULATED HIGHLY ACTIVE OMNI-79 NUCLEASE VARIANTS