IL326550A - שיטות לטיפול בהפרעות דם באמצעות נוגדנים חד-ספציפיים ממוקדי- vwf - Google Patents

שיטות לטיפול בהפרעות דם באמצעות נוגדנים חד-ספציפיים ממוקדי- vwf

Info

Publication number
IL326550A
IL326550A IL326550A IL32655026A IL326550A IL 326550 A IL326550 A IL 326550A IL 326550 A IL326550 A IL 326550A IL 32655026 A IL32655026 A IL 32655026A IL 326550 A IL326550 A IL 326550A
Authority
IL
Israel
Prior art keywords
vwf
targeted
methods
blood disorders
treating blood
Prior art date
Application number
IL326550A
Other languages
English (en)
Original Assignee
Hemab Aps
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hemab Aps filed Critical Hemab Aps
Publication of IL326550A publication Critical patent/IL326550A/he

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
IL326550A 2023-08-16 2024-08-16 שיטות לטיפול בהפרעות דם באמצעות נוגדנים חד-ספציפיים ממוקדי- vwf IL326550A (he)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202363519955P 2023-08-16 2023-08-16
PCT/EP2024/073157 WO2025037032A1 (en) 2023-08-16 2024-08-16 Methods of treating blood disorders with vwf-targeted monospecific antibodies

Publications (1)

Publication Number Publication Date
IL326550A true IL326550A (he) 2026-04-01

Family

ID=92675879

Family Applications (1)

Application Number Title Priority Date Filing Date
IL326550A IL326550A (he) 2023-08-16 2024-08-16 שיטות לטיפול בהפרעות דם באמצעות נוגדנים חד-ספציפיים ממוקדי- vwf

Country Status (6)

Country Link
AR (1) AR133583A1 (he)
AU (1) AU2024324856A1 (he)
CO (1) CO2026002476A2 (he)
IL (1) IL326550A (he)
TW (1) TW202509085A (he)
WO (1) WO2025037032A1 (he)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201707139D0 (en) * 2017-05-04 2017-06-21 Imp Innovations Ltd Polypeptides
CN119032109A (zh) * 2022-02-15 2024-11-26 赫迈博私人有限责任公司 用靶向vwf的单特异性抗体治疗血液病症的方法

Also Published As

Publication number Publication date
TW202509085A (zh) 2025-03-01
WO2025037032A1 (en) 2025-02-20
CO2026002476A2 (es) 2026-03-16
AU2024324856A1 (en) 2026-02-26
AR133583A1 (es) 2025-10-15

Similar Documents

Publication Publication Date Title
MY205967A (en) Monoclonal antibodies against the beta chain region of human trbv9
CA3244108A1 (en) METHODS FOR TREATING BLOOD DISORDERS WITH MONOSPACTIC ANTIBODY TARGETING VWF
PH12020551012A1 (en) Monoclonal antibodies and methods for using same
MY206214A (en) Monoclonal antibodies that bind specifically to human trbv9
IL316615A (he) נוגדנים ביספציפיים ושיטות לטיפול במחלת עיניים
AR098663A1 (es) Anticuerpos multifuncionales que se unen a egfr y met
IL285308A (he) שיטות לטיפול בסרטן העין באמצעות נוגדנים אנטי-met ומולקולות קושרות אנטיגן בי-ספציפיות הקושרות met
IL299339A (he) נוגדנים ושיטות לטיפול במחלות הקשורות לקלאודין
IL314322A (he) שיטות לטיפול בחולים עם מחלה המתווכת על ידי נוגדן עצמי
EP4139364A4 (en) Bispecific antibodies for treating cd47-associated diseases
IL287832A (he) שיטות למתן נוגדן anti-cd38 לטיפול במיאלומה נפוצה
EA202192907A1 (ru) Моноклональное антитело, которое специфически связывается с gitr
IL286337A (he) טיפול בסרטן עם נוגדנים ביספציפיים her2xcd3 בשילוב עם אנטי- her2 mab
PH12022550647A1 (en) Anti-stem cell factor antibodies and methods of use thereof
IL289842A (he) נוגדנים אנטי- liv1 אנושיים לטיפול בסרטן
EP4069747A4 (en) COMBINATION OF BISPECIFIC FUSION PROTEIN AND ANTI-HER2 ANTIBODIES FOR TREATING A TUMOR
IL317946A (he) שילובים של חלבונים מאוחים fc- הטרודימריים il15/il15r אלפא ונוגדנים ביספציפיים fcrh5xcd3 לטיפול בסרטן הדם
AR116668A1 (es) Anticuerpos agonistas contra cd200r y sus usos
EA201990613A1 (ru) Антитела против гремлина-1 (grem1) и способы их применения для лечения легочной артериальной гипертензии
IL291449A (he) שיטות בטיפול חולי אפילפסיה בפנפלוראמין
IL290892A (he) שיטות לטיפול במחלות כלי דם
IL326550A (he) שיטות לטיפול בהפרעות דם באמצעות נוגדנים חד-ספציפיים ממוקדי- vwf
CA3301362A1 (en) Methods of treating blood disorders with vwf-targeted monospecific antibodies
IL307556A (he) שיטות לטיפול בסרטן באמצעות נוגדים כנגד tigit
IL318036A (he) נוגדנים ביספציפיים אנטי- pcrv ו-psl לטיפול בברונכיאקטזיס