IL326348A - שיטות והרכבים לטיפול בגידולים ממאירים של מעטפת העצבים ההיקפיים - Google Patents

שיטות והרכבים לטיפול בגידולים ממאירים של מעטפת העצבים ההיקפיים

Info

Publication number
IL326348A
IL326348A IL326348A IL32634826A IL326348A IL 326348 A IL326348 A IL 326348A IL 326348 A IL326348 A IL 326348A IL 32634826 A IL32634826 A IL 32634826A IL 326348 A IL326348 A IL 326348A
Authority
IL
Israel
Prior art keywords
inhibitor
prmt5
disclosure
methods
compound
Prior art date
Application number
IL326348A
Other languages
English (en)
Inventor
Peter Olson
Lars Daniel Engstrom
Original Assignee
Mirati Therapeutics Inc
Peter Olson
Lars Daniel Engstrom
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mirati Therapeutics Inc, Peter Olson, Lars Daniel Engstrom filed Critical Mirati Therapeutics Inc
Publication of IL326348A publication Critical patent/IL326348A/he

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL326348A 2023-08-08 2024-08-05 שיטות והרכבים לטיפול בגידולים ממאירים של מעטפת העצבים ההיקפיים IL326348A (he)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202363518312P 2023-08-08 2023-08-08
US202363588563P 2023-10-06 2023-10-06
PCT/US2024/040932 WO2025034640A1 (en) 2023-08-08 2024-08-05 Methods and compositions for treating malignant peripheral nerve sheath tumors

Publications (1)

Publication Number Publication Date
IL326348A true IL326348A (he) 2026-04-01

Family

ID=92538872

Family Applications (1)

Application Number Title Priority Date Filing Date
IL326348A IL326348A (he) 2023-08-08 2024-08-05 שיטות והרכבים לטיפול בגידולים ממאירים של מעטפת העצבים ההיקפיים

Country Status (7)

Country Link
EP (1) EP4757812A1 (he)
KR (1) KR20260049253A (he)
CN (1) CN121646468A (he)
AU (1) AU2024320474A1 (he)
IL (1) IL326348A (he)
MX (1) MX2026001047A (he)
WO (1) WO2025034640A1 (he)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20260121A1 (es) 2023-04-21 2026-01-16 Gilead Sciences Inc Inhibidores de prmt5 y usos de los mismos

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20180271891A1 (en) * 2015-03-11 2018-09-27 The Broad Institute Inc. Selective treatment of prmt5 dependent cancer
CN120208880A (zh) 2019-09-12 2025-06-27 米拉蒂医疗股份有限公司 Mta-协同prmt5抑制剂
EP4304720A1 (en) 2021-03-11 2024-01-17 Mirati Therapeutics, Inc. Mta-cooperative prmt5 inhibitors
IL308853A (he) * 2021-06-02 2024-01-01 Ideaya Biosciences Inc שילוב של תרפיה הכוללת מעכב מאט 2איי וסוג ii מעכב פרמט
KR20250056257A (ko) * 2022-09-01 2025-04-25 미라티 테라퓨틱스, 인크. 암의 치료를 위한 prmt5 억제제 및 bcl-2 패밀리 억제제를 사용하는 조합 요법
WO2024170488A1 (en) * 2023-02-13 2024-08-22 Astrazeneca Ab Prmt5 inhibitor for use in cancer therapy

Also Published As

Publication number Publication date
CN121646468A (zh) 2026-03-10
WO2025034640A1 (en) 2025-02-13
KR20260049253A (ko) 2026-04-13
EP4757812A1 (en) 2026-06-17
AU2024320474A1 (en) 2026-03-26
MX2026001047A (es) 2026-03-02

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