IL326330A - תאים שעברו מודיפיקציה ושימושים בהם - Google Patents

תאים שעברו מודיפיקציה ושימושים בהם

Info

Publication number
IL326330A
IL326330A IL326330A IL32633026A IL326330A IL 326330 A IL326330 A IL 326330A IL 326330 A IL326330 A IL 326330A IL 32633026 A IL32633026 A IL 32633026A IL 326330 A IL326330 A IL 326330A
Authority
IL
Israel
Prior art keywords
modified cells
cells
modified
Prior art date
Application number
IL326330A
Other languages
English (en)
Inventor
Lingfeng Liu
Wenting Zhong
Lilin Liu
Original Assignee
St Phi Therapeutics Co Ltd
Lingfeng Liu
Wenting Zhong
Lilin Liu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by St Phi Therapeutics Co Ltd, Lingfeng Liu, Wenting Zhong, Lilin Liu filed Critical St Phi Therapeutics Co Ltd
Publication of IL326330A publication Critical patent/IL326330A/he

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/10Cellular immunotherapy characterised by the cell type used
    • A61K40/11T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/20Cellular immunotherapy characterised by the effect or the function of the cells
    • A61K40/22Immunosuppressive or immunotolerising
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/30Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • C07K14/7051T-cell receptor (TcR)-CD3 complex
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86Viral vectors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0636T lymphocytes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14Blood; Artificial blood
    • A61K35/17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50Cell markers; Cell surface determinants
    • C12N2501/51B7 molecules, e.g. CD80, CD86, CD28 (ligand), CD152 (ligand)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50Cell markers; Cell surface determinants
    • C12N2501/515CD3, T-cell receptor complex
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00Reverse transcribing RNA viruses
    • C12N2740/00011Details
    • C12N2740/10011Retroviridae
    • C12N2740/16011Human Immunodeficiency Virus, HIV
    • C12N2740/16041Use of virus, viral particle or viral elements as a vector
    • C12N2740/16043Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Developmental Biology & Embryology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Transplantation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL326330A 2023-08-03 2024-08-05 תאים שעברו מודיפיקציה ושימושים בהם IL326330A (he)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2023111061 2023-08-03
PCT/CN2024/109687 WO2025026449A1 (en) 2023-08-03 2024-08-05 Modified cells and uses thereof

Publications (1)

Publication Number Publication Date
IL326330A true IL326330A (he) 2026-04-01

Family

ID=94394148

Family Applications (1)

Application Number Title Priority Date Filing Date
IL326330A IL326330A (he) 2023-08-03 2024-08-05 תאים שעברו מודיפיקציה ושימושים בהם

Country Status (5)

Country Link
KR (1) KR20260049598A (he)
AU (1) AU2024318322A1 (he)
IL (1) IL326330A (he)
TW (1) TW202519650A (he)
WO (1) WO2025026449A1 (he)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7237449B2 (ja) * 2015-02-27 2023-03-13 アイセル・ジーン・セラピューティクス・エルエルシー 血液系腫瘍を標的としたキメラ抗体受容体(CARs)の構成およびその使用方法
US20200308248A1 (en) * 2019-03-26 2020-10-01 ST Phi Therapeutics Chimeric Natural Killer Cell Receptors and Method of Using Thereof
US12312407B2 (en) * 2020-01-30 2025-05-27 St Phi Therapeutics Co., Ltd. Universal T cells and the method of use thereof
CN116940367A (zh) * 2020-12-03 2023-10-24 恩卡尔塔公司 工程化改造免疫细胞用于增强的效力和持久性的方法以及工程化细胞在免疫疗法中的用途
IL304904A (he) * 2021-02-01 2023-10-01 St Phi Therapeutics Co Ltd מערכת דגרדציה לחלבון מטרה ושימוש בה
EP4378952A4 (en) * 2021-07-30 2025-09-24 St Phi Therapeutics Co Ltd UNIVERSAL T LYMPHOCYTE AND ITS USE

Also Published As

Publication number Publication date
KR20260049598A (ko) 2026-04-14
TW202519650A (zh) 2025-05-16
WO2025026449A1 (en) 2025-02-06
AU2024318322A1 (en) 2026-03-19

Similar Documents

Publication Publication Date Title
EP4089174A4 (en) MODIFIED IMMUNE CELL AND USE THEREOF
SG11202107269XA (en) Modified cell expansion and uses thereof
GB2604039B (en) Cell stack and cell stack assembly
SG11202111679XA (en) Engineered cells and uses thereof
GB202019019D0 (en) T cell receptors and uses thereof
GB202110124D0 (en) Sturgeon cells and extracts
GB202019623D0 (en) Electrochemical methods and materials
IL317532A (he) תאי גזע מהונדסים ושימושיהם
EP3907787A4 (en) CELL AND BATTERY WITH THIS CELL
SG10201909544YA (en) Genetically Modified T Cells And Uses Thereof
IL326330A (he) תאים שעברו מודיפיקציה ושימושים בהם
GB202211784D0 (en) Methods and uses
IL289564A (he) תאים שעברו שינוי ושיטות קשורות
CA3300566A1 (en) Modified cells and uses thereof
EP4107128A4 (en) CAPACITIVE FARADAY AND PSEUDO-CAPACITIVE FARADAY FUEL CELLS
GB202316503D0 (en) Novel cells and methods
GB202201997D0 (en) Cells and methods
EP4440597A4 (en) MODIFIED CELLS AND THEIR USES
AU2022903088A0 (en) Modified T cells and uses thereof
GB202202223D0 (en) Cell stack and cell stack assembly
GB202012727D0 (en) Modified host cells and uses thereof
GB202417085D0 (en) Electrolutic cells and their use
GB202302200D0 (en) Energy cell developmemts and applications
HUE069523T2 (hu) Akkumulátorcella és akkumulátor
GB202107185D0 (en) Composition and battery