IL325987A - תכשירים ושיטות להגבלת ביטוי מרכיב 3 של מערכת המשלים (c3) - Google Patents
תכשירים ושיטות להגבלת ביטוי מרכיב 3 של מערכת המשלים (c3)Info
- Publication number
- IL325987A IL325987A IL325987A IL32598726A IL325987A IL 325987 A IL325987 A IL 325987A IL 325987 A IL325987 A IL 325987A IL 32598726 A IL32598726 A IL 32598726A IL 325987 A IL325987 A IL 325987A
- Authority
- IL
- Israel
- Prior art keywords
- compositions
- methods
- complement component
- inhibiting expression
- inhibiting
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/322—2'-R Modification
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2023108507 | 2023-07-21 | ||
| PCT/CN2024/106297 WO2025021007A1 (en) | 2023-07-21 | 2024-07-19 | Compositions and methods for inhibiting expression of complement component 3 (c3) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL325987A true IL325987A (he) | 2026-03-01 |
Family
ID=94374155
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL325987A IL325987A (he) | 2023-07-21 | 2024-07-19 | תכשירים ושיטות להגבלת ביטוי מרכיב 3 של מערכת המשלים (c3) |
Country Status (7)
| Country | Link |
|---|---|
| KR (1) | KR20260041829A (he) |
| CN (1) | CN121488036A (he) |
| AU (1) | AU2024300829A1 (he) |
| IL (1) | IL325987A (he) |
| MX (1) | MX2026000754A (he) |
| TW (1) | TW202505027A (he) |
| WO (1) | WO2025021007A1 (he) |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020233680A1 (zh) * | 2019-05-22 | 2020-11-26 | 苏州瑞博生物技术股份有限公司 | 核酸、药物组合物与缀合物及制备方法和用途 |
| TW202134435A (zh) * | 2019-10-22 | 2021-09-16 | 美商阿尼拉製藥公司 | 補體成分ｃ３ ｉｒｎａ組成物及其使用方法 |
| CN115335524A (zh) * | 2020-02-14 | 2022-11-11 | 阿佩利斯制药有限公司 | 用于补体抑制的rna |
| WO2021178607A1 (en) * | 2020-03-05 | 2021-09-10 | Alnylam Pharmaceuticals, Inc. | Complement component c3 irna compositions and methods of use thereof for treating or preventing complement component c3-associated diseases |
| WO2022226127A1 (en) * | 2021-04-20 | 2022-10-27 | Alexion Pharmaceuticals, Inc. | Compositions and methods for inhibiting complement component 3 expression |
| CN115747216A (zh) * | 2021-09-02 | 2023-03-07 | 北京键凯科技股份有限公司 | 一种抑制补体因子c3表达的干扰rna及其应用 |
-
2024
- 2024-07-19 CN CN202480038706.9A patent/CN121488036A/zh active Pending
- 2024-07-19 AU AU2024300829A patent/AU2024300829A1/en active Pending
- 2024-07-19 KR KR1020267004121A patent/KR20260041829A/ko active Pending
- 2024-07-19 IL IL325987A patent/IL325987A/he unknown
- 2024-07-19 WO PCT/CN2024/106297 patent/WO2025021007A1/en active Pending
- 2024-07-19 TW TW113127013A patent/TW202505027A/zh unknown
-
2026
- 2026-01-19 MX MX2026000754A patent/MX2026000754A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TW202505027A (zh) | 2025-02-01 |
| AU2024300829A1 (en) | 2026-02-19 |
| WO2025021007A1 (en) | 2025-01-30 |
| CN121488036A (zh) | 2026-02-06 |
| MX2026000754A (es) | 2026-03-02 |
| KR20260041829A (ko) | 2026-03-27 |
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