IL325628A - Coagulation factor xi-modulating compositions and methods of use thereof - Google Patents

Coagulation factor xi-modulating compositions and methods of use thereof

Info

Publication number
IL325628A
IL325628A IL325628A IL32562825A IL325628A IL 325628 A IL325628 A IL 325628A IL 325628 A IL325628 A IL 325628A IL 32562825 A IL32562825 A IL 32562825A IL 325628 A IL325628 A IL 325628A
Authority
IL
Israel
Prior art keywords
methods
coagulation factor
modulating compositions
modulating
compositions
Prior art date
Application number
IL325628A
Other languages
Hebrew (he)
Inventor
Zhen Li
Rui Zhu
Alan Robert Macleod
Kimberly Fultz
Original Assignee
Adarx Pharmaceuticals Inc
Zhen Li
Rui Zhu
Alan Robert Macleod
Kimberly Fultz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adarx Pharmaceuticals Inc, Zhen Li, Rui Zhu, Alan Robert Macleod, Kimberly Fultz filed Critical Adarx Pharmaceuticals Inc
Publication of IL325628A publication Critical patent/IL325628A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6443—Coagulation factor XIa (3.4.21.27)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/317—Chemical structure of the backbone with an inverted bond, e.g. a cap structure
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/322—2'-R Modification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
    • C12N2310/3521—Methyl
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/353—Nature of the modification linked to the nucleic acid via an atom other than carbon
    • C12N2310/3533—Halogen

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
IL325628A 2023-07-21 2025-12-25 Coagulation factor xi-modulating compositions and methods of use thereof IL325628A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202363515074P 2023-07-21 2023-07-21
US202363583987P 2023-09-20 2023-09-20
PCT/US2024/038771 WO2025024283A1 (en) 2023-07-21 2024-07-19 Coagulation factor xi-modulating compositions and methods of use thereof

Publications (1)

Publication Number Publication Date
IL325628A true IL325628A (en) 2026-02-01

Family

ID=94375096

Family Applications (1)

Application Number Title Priority Date Filing Date
IL325628A IL325628A (en) 2023-07-21 2025-12-25 Coagulation factor xi-modulating compositions and methods of use thereof

Country Status (8)

Country Link
KR (1) KR20260042527A (en)
CN (1) CN121773204A (en)
AU (1) AU2024301682A1 (en)
CO (1) CO2026001057A2 (en)
IL (1) IL325628A (en)
MX (1) MX2026000791A (en)
TW (1) TW202521694A (en)
WO (1) WO2025024283A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN121320352B (en) * 2025-12-16 2026-04-07 北京悦康科创医药科技股份有限公司 Double-stranded ribonucleic acid for reducing blood coagulation factor XI expression, and modifier and application thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2019218987B2 (en) * 2018-02-12 2025-04-24 Ionis Pharmaceuticals, Inc. Modified compounds and uses thereof
US20240401045A1 (en) * 2021-10-01 2024-12-05 Adarx Pharmaceuticals, Inc. Angiotensinogen-modulating compositions and methods of use thereof

Also Published As

Publication number Publication date
KR20260042527A (en) 2026-03-31
TW202521694A (en) 2025-06-01
MX2026000791A (en) 2026-03-02
CN121773204A (en) 2026-03-31
WO2025024283A1 (en) 2025-01-30
CO2026001057A2 (en) 2026-02-13
AU2024301682A1 (en) 2026-01-22

Similar Documents

Publication Publication Date Title
IL308041A (en) Collagen compositions and methods of use thereof
IL309073A (en) Enantiomeric entactogen compositions and methods of their use
GB202205510D0 (en) Compositions of protein complexes and methods of use thereof
IL325628A (en) Coagulation factor xi-modulating compositions and methods of use thereof
IL312928A (en) Complement factor b-modulating compositions and methods of use thereof
EP4204004A4 (en) Anti-idiotype compositions and methods of use thereof
GB2622995B (en) CAS13-based compositions and methods of use thereof
IL318328A (en) Compositions including multi-agonist peptides and methods of manufacture and use
EP4110369A4 (en) Methods of treatment and related compositions
IL316049A (en) Pharmaceutical compositions of mosunetuzumab and methods of use
EP4381022A4 (en) Compositions and methods of use thereof
IL315862A (en) Angiotensinogen-modulating compositions and methods of use thereof
CA3257282A1 (en) Collagen compositions and methods of use thereof
IL314226A (en) Designed cytokine compositions and methods of use
IL321134A (en) Olanzapine compositions and methods of use
EP4125777A4 (en) High-strength collagen compositions and methods of use
CA3298878A1 (en) Coagulation factor xi-modulating compositions and methods of use thereof
IL312205A (en) Coxsackievirus b compositions and methods of use thereof
IL325884A (en) Gal475 compositions and methods of use thereof
IL326294A (en) Apilimod compositions and methods of use
GB202313643D0 (en) Serping1-sarna compositions and methods of use
GB202310868D0 (en) compositions and methods of use
IL311518A (en) Prekallikrein-modulating compositions and methods of use thereof
IL326328A (en) Acidic polymer compositions and methods of use thereof
CA3279096A1 (en) Coagulant compositions and methods of use