IL325482A - צורות גבישיות של 6-(6-(((1r,2r, 3s, 5s)-2-פלואורו-9-אזאביציקלו[3.3.1]נונאן-3-איל)(מתיל)אמינו)פירידאזין-3-איל)-2-מתילבנזו[d]אוקסאזול-5-אול, מאפנן חיבור לטיפול במחלת הנטינגטון - Google Patents

צורות גבישיות של 6-(6-(((1r,2r, 3s, 5s)-2-פלואורו-9-אזאביציקלו[3.3.1]נונאן-3-איל)(מתיל)אמינו)פירידאזין-3-איל)-2-מתילבנזו[d]אוקסאזול-5-אול, מאפנן חיבור לטיפול במחלת הנטינגטון

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Publication number
IL325482A
IL325482A IL325482A IL32548225A IL325482A IL 325482 A IL325482 A IL 325482A IL 325482 A IL325482 A IL 325482A IL 32548225 A IL32548225 A IL 32548225A IL 325482 A IL325482 A IL 325482A
Authority
IL
Israel
Prior art keywords
methylbenzo
nonan
pyridazin
oxazol
azabicyclo
Prior art date
Application number
IL325482A
Other languages
English (en)
Original Assignee
Skyhawk Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Skyhawk Therapeutics Inc filed Critical Skyhawk Therapeutics Inc
Publication of IL325482A publication Critical patent/IL325482A/he

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epidemiology (AREA)
IL325482A 2023-06-30 2025-12-21 צורות גבישיות של 6-(6-(((1r,2r, 3s, 5s)-2-פלואורו-9-אזאביציקלו[3.3.1]נונאן-3-איל)(מתיל)אמינו)פירידאזין-3-איל)-2-מתילבנזו[d]אוקסאזול-5-אול, מאפנן חיבור לטיפול במחלת הנטינגטון IL325482A (he)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202363511325P 2023-06-30 2023-06-30
PCT/US2024/036019 WO2025006887A1 (en) 2023-06-30 2024-06-28 Crystalline forms of 6-(6-(((1r,2r,3s,5s)-2-fluoro-9-azabicyclo[3.3.1]nonan-3-yl)(methyl)amino)pyridazin-3-yl)-2-methylbenzo[d]oxazol-5-ol, a splicing modulator for the treatment of huntington's disease

Publications (1)

Publication Number Publication Date
IL325482A true IL325482A (he) 2026-02-01

Family

ID=91966897

Family Applications (1)

Application Number Title Priority Date Filing Date
IL325482A IL325482A (he) 2023-06-30 2025-12-21 צורות גבישיות של 6-(6-(((1r,2r, 3s, 5s)-2-פלואורו-9-אזאביציקלו[3.3.1]נונאן-3-איל)(מתיל)אמינו)פירידאזין-3-איל)-2-מתילבנזו[d]אוקסאזול-5-אול, מאפנן חיבור לטיפול במחלת הנטינגטון

Country Status (7)

Country Link
EP (1) EP4735437A1 (he)
KR (1) KR20260044269A (he)
CN (1) CN121752562A (he)
AR (1) AR133116A1 (he)
AU (1) AU2024307361A1 (he)
IL (1) IL325482A (he)
WO (1) WO2025006887A1 (he)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114126613A (zh) 2019-02-05 2022-03-01 斯基霍克疗法公司 用于调节剪接的方法和组合物

Also Published As

Publication number Publication date
KR20260044269A (ko) 2026-04-01
AR133116A1 (es) 2025-08-27
CN121752562A (zh) 2026-03-27
AU2024307361A1 (en) 2026-01-22
EP4735437A1 (en) 2026-05-06
WO2025006887A1 (en) 2025-01-02

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