IL325481A - 6-(6-(((1 r,2r,3s,5s)-2-fluoro-9-azabicyclo[3.3.1]nonan-3-yl)(methyl)amino)pyrida zin-3- yl)-2- methylbenzo[d]oxazol-5-ol as a splicing modulator for the treatment of neurological diseases - Google Patents

6-(6-(((1 r,2r,3s,5s)-2-fluoro-9-azabicyclo[3.3.1]nonan-3-yl)(methyl)amino)pyrida zin-3- yl)-2- methylbenzo[d]oxazol-5-ol as a splicing modulator for the treatment of neurological diseases

Info

Publication number
IL325481A
IL325481A IL325481A IL32548125A IL325481A IL 325481 A IL325481 A IL 325481A IL 325481 A IL325481 A IL 325481A IL 32548125 A IL32548125 A IL 32548125A IL 325481 A IL325481 A IL 325481A
Authority
IL
Israel
Prior art keywords
methylbenzo
nonan
oxazol
azabicyclo
fluoro
Prior art date
Application number
IL325481A
Other languages
Hebrew (he)
Original Assignee
Skyhawk Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Skyhawk Therapeutics Inc filed Critical Skyhawk Therapeutics Inc
Publication of IL325481A publication Critical patent/IL325481A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Epidemiology (AREA)
IL325481A 2023-06-30 2025-12-21 6-(6-(((1 r,2r,3s,5s)-2-fluoro-9-azabicyclo[3.3.1]nonan-3-yl)(methyl)amino)pyrida zin-3- yl)-2- methylbenzo[d]oxazol-5-ol as a splicing modulator for the treatment of neurological diseases IL325481A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202363511248P 2023-06-30 2023-06-30
PCT/US2024/036007 WO2025006878A1 (en) 2023-06-30 2024-06-28 6-(6-(((1 r,2r,3s,5s)-2-fluoro-9-azabicyclo[3.3.1]nonan-3-yl)(methyl)amino)pyrida zin-3- yl)-2- methylbenzo[d]oxazol-5-ol as a splicing modulator for the treatment of neurological diseases

Publications (1)

Publication Number Publication Date
IL325481A true IL325481A (en) 2026-02-01

Family

ID=91961988

Family Applications (1)

Application Number Title Priority Date Filing Date
IL325481A IL325481A (en) 2023-06-30 2025-12-21 6-(6-(((1 r,2r,3s,5s)-2-fluoro-9-azabicyclo[3.3.1]nonan-3-yl)(methyl)amino)pyrida zin-3- yl)-2- methylbenzo[d]oxazol-5-ol as a splicing modulator for the treatment of neurological diseases

Country Status (8)

Country Link
EP (1) EP4735436A1 (en)
KR (1) KR20260034664A (en)
AR (1) AR133109A1 (en)
AU (1) AU2024308579B2 (en)
CO (1) CO2026000677A2 (en)
IL (1) IL325481A (en)
MX (1) MX2026000027A (en)
WO (1) WO2025006878A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025255218A1 (en) * 2024-06-05 2025-12-11 Skyhawk Therapeutics, Inc. Compositions and methods for modulating splicing

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114126613A (en) 2019-02-05 2022-03-01 斯基霍克疗法公司 Methods and compositions for modulating splicing

Also Published As

Publication number Publication date
EP4735436A1 (en) 2026-05-06
AU2024308579A1 (en) 2026-01-22
WO2025006878A1 (en) 2025-01-02
MX2026000027A (en) 2026-02-03
KR20260034664A (en) 2026-03-11
AU2024308579B2 (en) 2026-04-23
CO2026000677A2 (en) 2026-02-02
AR133109A1 (en) 2025-08-27

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