IL322583A - Dendrimer-like hyperbranched macromolecules based on polyethylene glycol, methods of their preparation and applications - Google Patents

Dendrimer-like hyperbranched macromolecules based on polyethylene glycol, methods of their preparation and applications

Info

Publication number
IL322583A
IL322583A IL322583A IL32258325A IL322583A IL 322583 A IL322583 A IL 322583A IL 322583 A IL322583 A IL 322583A IL 32258325 A IL32258325 A IL 32258325A IL 322583 A IL322583 A IL 322583A
Authority
IL
Israel
Prior art keywords
hyperbranched macromolecule
hyperbranched
dendritic
click chemistry
polymeric
Prior art date
Application number
IL322583A
Other languages
English (en)
Hebrew (he)
Inventor
Bin Zhao
Peter Jarrett
Rami El-Hayek
Fadi Haso
Marc Plante
Yiwen Li
Original Assignee
Ocular Therapeutix Inc
Bin Zhao
Peter Jarrett
El Hayek Rami
Fadi Haso
Marc Plante
Yiwen Li
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ocular Therapeutix Inc, Bin Zhao, Peter Jarrett, El Hayek Rami, Fadi Haso, Marc Plante, Yiwen Li filed Critical Ocular Therapeutix Inc
Publication of IL322583A publication Critical patent/IL322583A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G81/00—Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G83/00—Macromolecular compounds not provided for in groups C08G2/00 - C08G81/00
    • C08G83/002—Dendritic macromolecules
    • C08G83/005—Hyperbranched macromolecules
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L101/00—Compositions of unspecified macromolecular compounds
    • C08L101/16—Compositions of unspecified macromolecular compounds the macromolecular compounds being biodegradable

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Polyethers (AREA)
IL322583A 2023-03-21 2024-03-21 Dendrimer-like hyperbranched macromolecules based on polyethylene glycol, methods of their preparation and applications IL322583A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202363453619P 2023-03-21 2023-03-21
PCT/US2024/020893 WO2024197137A2 (en) 2023-03-21 2024-03-21 Poly(ethylene glycol) based dendrimer-like hyperbranched macromolecules, methods of preparation and use thereof

Publications (1)

Publication Number Publication Date
IL322583A true IL322583A (en) 2025-10-01

Family

ID=92842527

Family Applications (1)

Application Number Title Priority Date Filing Date
IL322583A IL322583A (en) 2023-03-21 2024-03-21 Dendrimer-like hyperbranched macromolecules based on polyethylene glycol, methods of their preparation and applications

Country Status (9)

Country Link
EP (1) EP4683964A2 (de)
JP (1) JP2026511054A (de)
KR (1) KR20250160197A (de)
CN (1) CN120858129A (de)
AU (1) AU2024238378A1 (de)
IL (1) IL322583A (de)
MX (1) MX2025011128A (de)
TW (1) TW202502386A (de)
WO (1) WO2024197137A2 (de)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI246524B (en) * 2001-01-19 2006-01-01 Shearwater Corp Multi-arm block copolymers as drug delivery vehicles
CN102906157B (zh) * 2010-03-01 2016-08-24 不列颠哥伦比亚大学 衍生的超支化聚丙三醇
AU2012296950B2 (en) * 2011-08-12 2016-09-22 Ascendis Pharma A/S Polymeric hyperbranched carrier-linked prodrugs
EP3078699B1 (de) * 2013-12-02 2019-08-21 Jenkem Technology Co. Ltd. (Tianjin) Mehrarmiges polyethylen-glycol-nitrin-derivat
US20150266986A1 (en) * 2014-03-20 2015-09-24 National University Of Ireland, Galway Multifunctional Hyperbranched Polymers

Also Published As

Publication number Publication date
CN120858129A (zh) 2025-10-28
WO2024197137A3 (en) 2024-10-31
JP2026511054A (ja) 2026-04-10
KR20250160197A (ko) 2025-11-11
EP4683964A2 (de) 2026-01-28
TW202502386A (zh) 2025-01-16
WO2024197137A2 (en) 2024-09-26
MX2025011128A (es) 2025-10-01
AU2024238378A1 (en) 2025-10-16

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