IL320539A - תרכובות אימידאזול ושימושיהן כמעכבי תעלות נתרן - Google Patents
תרכובות אימידאזול ושימושיהן כמעכבי תעלות נתרןInfo
- Publication number
- IL320539A IL320539A IL320539A IL32053925A IL320539A IL 320539 A IL320539 A IL 320539A IL 320539 A IL320539 A IL 320539A IL 32053925 A IL32053925 A IL 32053925A IL 320539 A IL320539 A IL 320539A
- Authority
- IL
- Israel
- Prior art keywords
- sodium channel
- imidazole compounds
- channel inhibitors
- inhibitors
- imidazole
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202263420877P | 2022-10-31 | 2022-10-31 | |
| US202263420883P | 2022-10-31 | 2022-10-31 | |
| PCT/US2023/036385 WO2024097171A1 (en) | 2022-10-31 | 2023-10-31 | Imidazole compounds and their use as sodium channel inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL320539A true IL320539A (he) | 2025-06-01 |
Family
ID=90931320
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL320539A IL320539A (he) | 2022-10-31 | 2023-10-31 | תרכובות אימידאזול ושימושיהן כמעכבי תעלות נתרן |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP4611747A1 (he) |
| JP (1) | JP2025536577A (he) |
| KR (1) | KR20250099373A (he) |
| CN (1) | CN120513089A (he) |
| AU (1) | AU2023374468A1 (he) |
| IL (1) | IL320539A (he) |
| WO (1) | WO2024097171A1 (he) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2025122845A1 (en) * | 2023-12-07 | 2025-06-12 | Genep Inc. | Imidazole compounds and their use as sodium channel inhibitors |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2825926A1 (fr) * | 2001-06-14 | 2002-12-20 | Sod Conseils Rech Applic | Derives d'imidazoles modulant les canaux sodiques |
| TW202003490A (zh) * | 2018-05-22 | 2020-01-16 | 瑞士商赫孚孟拉羅股份公司 | 治療性化合物及其使用方法 |
-
2023
- 2023-10-31 CN CN202380082812.2A patent/CN120513089A/zh active Pending
- 2023-10-31 EP EP23886607.3A patent/EP4611747A1/en active Pending
- 2023-10-31 IL IL320539A patent/IL320539A/he unknown
- 2023-10-31 KR KR1020257018064A patent/KR20250099373A/ko active Pending
- 2023-10-31 JP JP2025524988A patent/JP2025536577A/ja active Pending
- 2023-10-31 AU AU2023374468A patent/AU2023374468A1/en active Pending
- 2023-10-31 WO PCT/US2023/036385 patent/WO2024097171A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2024097171A1 (en) | 2024-05-10 |
| CN120513089A (zh) | 2025-08-19 |
| EP4611747A1 (en) | 2025-09-10 |
| KR20250099373A (ko) | 2025-07-01 |
| AU2023374468A1 (en) | 2025-06-05 |
| JP2025536577A (ja) | 2025-11-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL324670A (he) | מעכבי kras | |
| IL317736A (he) | תרכובות כמעכבות של axl | |
| IL314049A (he) | מעכבי parp7 | |
| IL324796A (he) | תרכובות מעכב parp1 | |
| AU2024316010A1 (en) | Pi3k inhibitors | |
| EP4419511A4 (en) | COMPOUNDS AND THEIR USE AS GPR183 INHIBITORS | |
| IL320539A (he) | תרכובות אימידאזול ושימושיהן כמעכבי תעלות נתרן | |
| IL319012A (he) | מעכבי sik heterocyclic | |
| IL324629A (he) | מעכבי ציקלין | |
| IL315980A (he) | מעכבי egfr | |
| PT4214210T (pt) | Compostos e composições como inibidores de sppl2a | |
| CA3272065A1 (en) | Imidazole compounds and their use as sodium channel inhibitors | |
| GB202307924D0 (en) | Inhibitor compounds | |
| IL316378A (he) | מעכבי פיאי3קיאי (pi3kα) | |
| GB202505800D0 (en) | Inhibitors | |
| GB202416727D0 (en) | RAB27 inhibitors | |
| GB202416258D0 (en) | Inhibitors | |
| IL320219A (he) | מעכבים | |
| GB202209170D0 (en) | Antiseptic composition | |
| CA223162S (en) | Swab | |
| CA3287411A1 (en) | Compounds and their uses as gpr183 inhibitors | |
| GB202203181D0 (en) | Inhibitors of elF4A | |
| GB202016697D0 (en) | Compound and composition for use | |
| GB202202970D0 (en) | Composition for use | |
| GB202213863D0 (en) | Agent |