IL318955A - תרכובות פירידינון מותמר כמעכבי cbl-b - Google Patents
תרכובות פירידינון מותמר כמעכבי cbl-bInfo
- Publication number
- IL318955A IL318955A IL318955A IL31895525A IL318955A IL 318955 A IL318955 A IL 318955A IL 318955 A IL318955 A IL 318955A IL 31895525 A IL31895525 A IL 31895525A IL 318955 A IL318955 A IL 318955A
- Authority
- IL
- Israel
- Prior art keywords
- cbl
- inhibitors
- pyridinone compounds
- substituted pyridinone
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN202221046493 | 2022-08-16 | ||
| PCT/IB2023/058197 WO2024038378A1 (en) | 2022-08-16 | 2023-08-15 | Substituted pyridinone compounds as cbl-b inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL318955A true IL318955A (he) | 2025-04-01 |
Family
ID=87929171
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL318955A IL318955A (he) | 2022-08-16 | 2023-08-15 | תרכובות פירידינון מותמר כמעכבי cbl-b |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP4573085A1 (he) |
| JP (1) | JP2025525947A (he) |
| KR (1) | KR20250050018A (he) |
| CN (1) | CN119546587A (he) |
| AU (1) | AU2023326220A1 (he) |
| CA (1) | CA3258870A1 (he) |
| CL (1) | CL2025000120A1 (he) |
| CO (1) | CO2025003090A2 (he) |
| CU (1) | CU20250003A7 (he) |
| IL (1) | IL318955A (he) |
| MX (1) | MX2025001865A (he) |
| PE (1) | PE20251389A1 (he) |
| WO (1) | WO2024038378A1 (he) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2025076299A1 (en) * | 2023-10-06 | 2025-04-10 | Arcus Biosciences, Inc. | Cbl-b inhibitors and methods of use thereof |
| WO2025214476A1 (zh) * | 2024-04-11 | 2025-10-16 | 北京诺诚健华医药科技有限公司 | Cbl-b抑制剂 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019148005A1 (en) | 2018-01-26 | 2019-08-01 | Nurix Therapeutics, Inc. | Inhibitors of cbl-b and methods of use thereof |
| EP3953346A1 (en) | 2019-04-09 | 2022-02-16 | Nurix Therapeutics, Inc. | 3-substituted piperidine compounds for cbl-b inhibition, and use of a cbl-b inhibitor in combination with a cancer vaccine and/or oncolytic virus |
| EP3969447A1 (en) | 2019-05-17 | 2022-03-23 | Nurix Therapeutics, Inc. | Cyano cyclobutyl compounds for cbl-b inhibition and uses thereof |
| MX2021015675A (es) | 2019-06-26 | 2022-02-03 | Nurix Therapeutics Inc | Compuestos de bencil-triazol sustituidos para la inhibicion de cbl-b y otros usos de los mismos. |
| WO2021021761A1 (en) | 2019-07-30 | 2021-02-04 | Nurix Therapeutics, Inc. | Urea, amide, and substituted heteroaryl compounds for cbl-b inhibition |
| EP4034141A1 (en) | 2019-09-24 | 2022-08-03 | Nurix Therapeutics, Inc. | Cbl inhibitors and compositions for expansion of immune cells |
| WO2022169998A1 (en) * | 2021-02-03 | 2022-08-11 | Genentech, Inc. | Amides as cbl-b inhibitors |
-
2023
- 2023-08-15 JP JP2025506125A patent/JP2025525947A/ja active Pending
- 2023-08-15 EP EP23764707.8A patent/EP4573085A1/en active Pending
- 2023-08-15 WO PCT/IB2023/058197 patent/WO2024038378A1/en not_active Ceased
- 2023-08-15 AU AU2023326220A patent/AU2023326220A1/en active Pending
- 2023-08-15 IL IL318955A patent/IL318955A/he unknown
- 2023-08-15 CN CN202380053674.5A patent/CN119546587A/zh active Pending
- 2023-08-15 PE PE2025000152A patent/PE20251389A1/es unknown
- 2023-08-15 CU CU2025000003A patent/CU20250003A7/es unknown
- 2023-08-15 CA CA3258870A patent/CA3258870A1/en active Pending
- 2023-08-15 KR KR1020257001536A patent/KR20250050018A/ko active Pending
-
2025
- 2025-01-15 CL CL2025000120A patent/CL2025000120A1/es unknown
- 2025-02-13 MX MX2025001865A patent/MX2025001865A/es unknown
- 2025-03-10 CO CONC2025/0003090A patent/CO2025003090A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA3258870A1 (en) | 2024-02-22 |
| CO2025003090A2 (es) | 2025-03-27 |
| KR20250050018A (ko) | 2025-04-14 |
| MX2025001865A (es) | 2025-04-02 |
| JP2025525947A (ja) | 2025-08-07 |
| CU20250003A7 (es) | 2025-09-01 |
| AU2023326220A1 (en) | 2025-02-20 |
| PE20251389A1 (es) | 2025-05-22 |
| CL2025000120A1 (es) | 2025-06-13 |
| WO2024038378A1 (en) | 2024-02-22 |
| CN119546587A (zh) | 2025-02-28 |
| EP4573085A1 (en) | 2025-06-25 |
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