IL315599A - תהליך הכנת אגוניסט כפול glp-1/glucagon - Google Patents
תהליך הכנת אגוניסט כפול glp-1/glucagonInfo
- Publication number
- IL315599A IL315599A IL315599A IL31559924A IL315599A IL 315599 A IL315599 A IL 315599A IL 315599 A IL315599 A IL 315599A IL 31559924 A IL31559924 A IL 31559924A IL 315599 A IL315599 A IL 315599A
- Authority
- IL
- Israel
- Prior art keywords
- glp
- preparing
- dual agonist
- glucagon dual
- glucagon
- Prior art date
Links
- 101100337060 Caenorhabditis elegans glp-1 gene Proteins 0.000 title 1
- 102000051325 Glucagon Human genes 0.000 title 1
- 108060003199 Glucagon Proteins 0.000 title 1
- 229940125542 dual agonist Drugs 0.000 title 1
- MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 title 1
- 229960004666 glucagon Drugs 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1021—Tetrapeptides with the first amino acid being acidic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202263327120P | 2022-04-04 | 2022-04-04 | |
| PCT/US2023/065258 WO2023196765A1 (en) | 2022-04-04 | 2023-04-03 | Process for preparing a glp-1/glucagon dual agonist |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL315599A true IL315599A (he) | 2024-11-01 |
Family
ID=86052320
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL315599A IL315599A (he) | 2022-04-04 | 2023-04-03 | תהליך הכנת אגוניסט כפול glp-1/glucagon |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP4504765A1 (he) |
| JP (1) | JP2025511318A (he) |
| KR (1) | KR20240154654A (he) |
| CN (1) | CN119053617A (he) |
| AR (1) | AR128996A1 (he) |
| AU (1) | AU2023249516A1 (he) |
| CA (1) | CA3246629A1 (he) |
| IL (1) | IL315599A (he) |
| TW (1) | TW202404996A (he) |
| WO (1) | WO2023196765A1 (he) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2025533109A (ja) * | 2022-10-05 | 2025-10-03 | イーライ リリー アンド カンパニー | インクレチン合成のためのペプチド |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110046349A1 (en) | 2009-07-15 | 2011-02-24 | Matthieu Giraud | Process for the production of exenatide and of an exenatide analogue |
| TWI783244B (zh) * | 2015-06-22 | 2022-11-11 | 美商美國禮來大藥廠 | 升糖素及glp-1共激動劑化合物 |
| TWI799680B (zh) | 2019-01-29 | 2023-04-21 | 美商美國禮來大藥廠 | 製備gip/glp1雙重促效劑之方法 |
| MX2022002115A (es) * | 2019-08-19 | 2022-03-17 | Lilly Co Eli | Metodos para preparar analogos de incretina. |
| AR122579A1 (es) | 2020-06-12 | 2022-09-21 | Lilly Co Eli | Proceso para preparar un agonista dual glp-1 / glucagón |
-
2023
- 2023-03-31 TW TW112112452A patent/TW202404996A/zh unknown
- 2023-04-03 EP EP23717812.4A patent/EP4504765A1/en active Pending
- 2023-04-03 WO PCT/US2023/065258 patent/WO2023196765A1/en not_active Ceased
- 2023-04-03 JP JP2024558341A patent/JP2025511318A/ja active Pending
- 2023-04-03 AU AU2023249516A patent/AU2023249516A1/en active Pending
- 2023-04-03 CA CA3246629A patent/CA3246629A1/en active Pending
- 2023-04-03 IL IL315599A patent/IL315599A/he unknown
- 2023-04-03 KR KR1020247032858A patent/KR20240154654A/ko active Pending
- 2023-04-03 CN CN202380031955.0A patent/CN119053617A/zh active Pending
- 2023-04-04 AR ARP230100843A patent/AR128996A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2023249516A1 (en) | 2024-09-19 |
| JP2025511318A (ja) | 2025-04-15 |
| EP4504765A1 (en) | 2025-02-12 |
| CA3246629A1 (en) | 2023-10-12 |
| KR20240154654A (ko) | 2024-10-25 |
| WO2023196765A1 (en) | 2023-10-12 |
| AR128996A1 (es) | 2024-07-03 |
| TW202404996A (zh) | 2024-02-01 |
| CN119053617A (zh) | 2024-11-29 |
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