IL315581A - Bi-functional molecules to degrade circulating proteins - Google Patents
Bi-functional molecules to degrade circulating proteinsInfo
- Publication number
- IL315581A IL315581A IL315581A IL31558124A IL315581A IL 315581 A IL315581 A IL 315581A IL 315581 A IL315581 A IL 315581A IL 31558124 A IL31558124 A IL 31558124A IL 315581 A IL315581 A IL 315581A
- Authority
- IL
- Israel
- Prior art keywords
- degrade
- functional molecules
- circulating proteins
- proteins
- circulating
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
- C07H15/08—Polyoxyalkylene derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
- C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/18—Acyclic radicals, substituted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/056—Triazole or tetrazole radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17/695,259 US20230097887A1 (en) | 2018-04-09 | 2022-03-15 | Bi-functional Molecules to Degrade Circulating Proteins |
| PCT/US2023/064436 WO2023178179A2 (en) | 2022-03-15 | 2023-03-15 | Bi-functional molecules to degrade circulating proteins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL315581A true IL315581A (en) | 2024-11-01 |
Family
ID=88024435
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL315581A IL315581A (en) | 2022-03-15 | 2023-03-15 | Bi-functional molecules to degrade circulating proteins |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP4493220A2 (en) |
| JP (1) | JP2025509736A (en) |
| KR (1) | KR20250004953A (en) |
| CN (1) | CN119212726A (en) |
| AU (1) | AU2023234543A1 (en) |
| IL (1) | IL315581A (en) |
| MX (1) | MX2024011358A (en) |
| WO (1) | WO2023178179A2 (en) |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10358497B2 (en) * | 2015-09-29 | 2019-07-23 | Amgen Inc. | Methods of treating cardiovascular disease with an ASGR inhibitor |
| WO2019199634A1 (en) * | 2018-04-09 | 2019-10-17 | Yale University | Bifunctional small molecules to target the selective degradation of circulating proteins |
| EP3773729A4 (en) * | 2018-04-09 | 2022-05-04 | Yale University | BI-FUNCTIONAL MOLECULES TO DEGRADE CIRCULATING PROTEINS |
| US20220023434A1 (en) * | 2018-12-19 | 2022-01-27 | The Board Of Trustees Of The Leland Stanford Junior University | Bifunctional Molecules for Lysosomal Targeting and Related Compositions and Methods |
| JP2023511756A (en) * | 2020-01-31 | 2023-03-22 | アヴィラー セラピューティクス インコーポレイテッド | ASGPR-binding compounds that degrade extracellular proteins |
-
2023
- 2023-03-15 IL IL315581A patent/IL315581A/en unknown
- 2023-03-15 WO PCT/US2023/064436 patent/WO2023178179A2/en not_active Ceased
- 2023-03-15 CN CN202380040375.8A patent/CN119212726A/en active Pending
- 2023-03-15 JP JP2024555118A patent/JP2025509736A/en active Pending
- 2023-03-15 AU AU2023234543A patent/AU2023234543A1/en active Pending
- 2023-03-15 KR KR1020247033971A patent/KR20250004953A/en active Pending
- 2023-03-15 EP EP23771634.5A patent/EP4493220A2/en active Pending
-
2024
- 2024-09-13 MX MX2024011358A patent/MX2024011358A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2025509736A (en) | 2025-04-11 |
| WO2023178179A2 (en) | 2023-09-21 |
| CN119212726A (en) | 2024-12-27 |
| KR20250004953A (en) | 2025-01-08 |
| AU2023234543A1 (en) | 2024-10-03 |
| MX2024011358A (en) | 2025-01-09 |
| WO2023178179A3 (en) | 2023-10-26 |
| EP4493220A2 (en) | 2025-01-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP3773729A4 (en) | BI-FUNCTIONAL MOLECULES TO DEGRADE CIRCULATING PROTEINS | |
| EP3773727A4 (en) | Bifunctional small molecules to target the selective degradation of circulating proteins | |
| IL277472A (en) | Nucleic acid molecules for pseudouridylation | |
| GB2605850B (en) | Bioprocessing system | |
| ES3058503T3 (en) | Circulating conveyor | |
| IL315579A (en) | Bifunctional small molecules to target the selective degradation of circulating proteins | |
| IL289266A (en) | Novel molecules | |
| GB202312395D0 (en) | Not yet published | |
| IL315581A (en) | Bi-functional molecules to degrade circulating proteins | |
| BR112015019719A2 (en) | ENHANCED TNF-BINDING PROTEINS | |
| HK40124104A (en) | Bi-functional molecules to degrade circulating proteins | |
| GB202313401D0 (en) | Not yet published | |
| HK40046119A (en) | Bi-functional molecules to degrade circulating proteins | |
| GB202406206D0 (en) | Not yet published | |
| GB202313110D0 (en) | Not yet published | |
| GB202313050D0 (en) | Not yet published | |
| GB202303543D0 (en) | Bioprocessing system | |
| GB202303541D0 (en) | Bioprocessing system | |
| GB202408162D0 (en) | Tumour-transforming multispecific proteins | |
| GB202319967D0 (en) | Heteromultimeric proteins | |
| GB202312969D0 (en) | Modified proteins | |
| GB202318520D0 (en) | Molecules | |
| GB202308142D0 (en) | Molecules | |
| GB202411954D0 (en) | Heteromultimeric proteins | |
| GB202510176D0 (en) | Multispecific molecules |