IL312661A - Methods and preparations for maintaining and expanding hematopoietic stem cells - Google Patents
Methods and preparations for maintaining and expanding hematopoietic stem cellsInfo
- Publication number
- IL312661A IL312661A IL312661A IL31266124A IL312661A IL 312661 A IL312661 A IL 312661A IL 312661 A IL312661 A IL 312661A IL 31266124 A IL31266124 A IL 31266124A IL 312661 A IL312661 A IL 312661A
- Authority
- IL
- Israel
- Prior art keywords
- compositions
- maintaining
- methods
- stem cells
- hematopoietic stem
- Prior art date
Links
- 210000003958 hematopoietic stem cell Anatomy 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/38—Vitamins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/42—Organic phosphate, e.g. beta glycerophosphate
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/125—Stem cell factor [SCF], c-kit ligand [KL]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/145—Thrombopoietin [TPO]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/15—Transforming growth factor beta (TGF-β)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/42—Notch; Delta; Jagged; Serrate
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Developmental Biology & Embryology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163284360P | 2021-11-30 | 2021-11-30 | |
| PCT/US2022/051195 WO2023101943A1 (en) | 2021-11-30 | 2022-11-29 | Methods and compositions for maintaining and expanding hematopoietic stem cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL312661A true IL312661A (en) | 2024-07-01 |
Family
ID=84901401
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL312661A IL312661A (en) | 2021-11-30 | 2022-11-29 | Methods and preparations for maintaining and expanding hematopoietic stem cells |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20230167408A1 (https=) |
| EP (1) | EP4441205A1 (https=) |
| JP (1) | JP2024541616A (https=) |
| KR (1) | KR20240110653A (https=) |
| CN (1) | CN118302519A (https=) |
| AU (1) | AU2022399413A1 (https=) |
| CA (1) | CA3238518A1 (https=) |
| IL (1) | IL312661A (https=) |
| WO (1) | WO2023101943A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2025080674A1 (en) | 2023-10-09 | 2025-04-17 | Trailhead Biosystems Inc. | Methods to improve enduring hematopoietic stem cell transplantation |
| WO2025129033A1 (en) * | 2023-12-14 | 2025-06-19 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for hematopoietic stem and progenitor cell expansion |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2488425A1 (en) * | 2002-06-07 | 2003-12-18 | Es Cell International Pte Ltd | Methods of regulating differentiation in stem cells |
| CA2948871A1 (en) * | 2014-05-22 | 2015-11-26 | Fred Hutchinson Cancer Research Center | Lilrb2 and notch-mediated expansion of hematopoietic precursor cells |
| US10669528B2 (en) * | 2015-06-25 | 2020-06-02 | Children's Medical Center Corporation | Methods and compositions relating to hematopoietic stem cell expansion, enrichment, and maintenance |
| EP4049665B1 (en) * | 2016-03-15 | 2025-03-12 | The Children's Medical Center Corporation | Methods and compositions relating to hematopoietic stem cell expansion |
| US20180163177A1 (en) * | 2016-12-11 | 2018-06-14 | Healthbanks Biotech Co. Ltd. | Serum-free culture medium and method for expanding hematopoietic stem cells |
| GB201706544D0 (en) * | 2017-04-25 | 2017-06-07 | Plasticell Ltd | Method |
| CN114286860A (zh) * | 2019-08-29 | 2022-04-05 | 味之素株式会社 | 由含有间充质干细胞的生物来源细胞试样制造间充质干细胞的方法 |
-
2022
- 2022-11-29 WO PCT/US2022/051195 patent/WO2023101943A1/en not_active Ceased
- 2022-11-29 EP EP22840471.1A patent/EP4441205A1/en active Pending
- 2022-11-29 KR KR1020247021309A patent/KR20240110653A/ko active Pending
- 2022-11-29 IL IL312661A patent/IL312661A/en unknown
- 2022-11-29 AU AU2022399413A patent/AU2022399413A1/en active Pending
- 2022-11-29 CA CA3238518A patent/CA3238518A1/en active Pending
- 2022-11-29 JP JP2024532440A patent/JP2024541616A/ja active Pending
- 2022-11-29 CN CN202280078418.7A patent/CN118302519A/zh active Pending
- 2022-11-29 US US18/071,388 patent/US20230167408A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN118302519A (zh) | 2024-07-05 |
| JP2024541616A (ja) | 2024-11-08 |
| WO2023101943A1 (en) | 2023-06-08 |
| KR20240110653A (ko) | 2024-07-15 |
| AU2022399413A1 (en) | 2024-05-23 |
| EP4441205A1 (en) | 2024-10-09 |
| US20230167408A1 (en) | 2023-06-01 |
| CA3238518A1 (en) | 2023-06-08 |
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