IL311663A - Use of PRMT5 inhibitors to treat cancer - Google Patents
Use of PRMT5 inhibitors to treat cancerInfo
- Publication number
- IL311663A IL311663A IL311663A IL31166324A IL311663A IL 311663 A IL311663 A IL 311663A IL 311663 A IL311663 A IL 311663A IL 31166324 A IL31166324 A IL 31166324A IL 311663 A IL311663 A IL 311663A
- Authority
- IL
- Israel
- Prior art keywords
- alkyl
- cancer
- hydrogen
- methyl
- haloalkyl
- Prior art date
Links
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- 125000004627 thianthrenyl group Chemical group C1(=CC=CC=2SC3=CC=CC=C3SC12)* 0.000 description 1
- 125000001984 thiazolidinyl group Chemical group 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
- 125000005302 thiazolylmethyl group Chemical group [H]C1=C([H])N=C(S1)C([H])([H])* 0.000 description 1
- DBDCNCCRPKTRSD-UHFFFAOYSA-N thieno[3,2-b]pyridine Chemical compound C1=CC=C2SC=CC2=N1 DBDCNCCRPKTRSD-UHFFFAOYSA-N 0.000 description 1
- RBNBDIMXFJYDLQ-UHFFFAOYSA-N thieno[3,2-d]pyrimidine Chemical compound C1=NC=C2SC=CC2=N1 RBNBDIMXFJYDLQ-UHFFFAOYSA-N 0.000 description 1
- 229940125670 thienopyridine Drugs 0.000 description 1
- 239000002175 thienopyridine Substances 0.000 description 1
- 125000004568 thiomorpholinyl group Chemical group 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 206010044412 transitional cell carcinoma Diseases 0.000 description 1
- 125000004306 triazinyl group Chemical group 0.000 description 1
- 125000005455 trithianyl group Chemical group 0.000 description 1
- 208000022271 tubular adenoma Diseases 0.000 description 1
- 210000003708 urethra Anatomy 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
- 210000001215 vagina Anatomy 0.000 description 1
- 208000009540 villous adenoma Diseases 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 210000003905 vulva Anatomy 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
- 125000001834 xanthenyl group Chemical group C1=CC=CC=2OC3=CC=CC=C3C(C12)* 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163252995P | 2021-10-06 | 2021-10-06 | |
| PCT/US2022/045895 WO2023059795A1 (en) | 2021-10-06 | 2022-10-06 | Combination therapies using prmt5 inhibitors for the treatment of cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL311663A true IL311663A (en) | 2024-05-01 |
Family
ID=84053165
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL311663A IL311663A (en) | 2021-10-06 | 2022-10-06 | Use of PRMT5 inhibitors to treat cancer |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20240398795A1 (https=) |
| EP (1) | EP4412607A1 (https=) |
| JP (1) | JP2024538719A (https=) |
| KR (1) | KR20240095421A (https=) |
| CN (1) | CN118251218A (https=) |
| AU (1) | AU2022360837A1 (https=) |
| CA (1) | CA3233157A1 (https=) |
| IL (1) | IL311663A (https=) |
| MX (1) | MX2024004171A (https=) |
| WO (1) | WO2023059795A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023202626A1 (zh) * | 2022-04-22 | 2023-10-26 | 北京望实智慧科技有限公司 | 稠和哒嗪酮化合物作为prmt5抑制剂 |
| CN119301101A (zh) * | 2022-07-29 | 2025-01-10 | 四川科伦博泰生物医药股份有限公司 | 甲基吡唑化合物、包含其的药物组合物及其制备方法和用途 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0922332D0 (en) * | 2009-12-22 | 2010-02-03 | Isis Innovation | Method of treatment and screening method |
| EP3177288A4 (en) * | 2014-08-04 | 2018-04-04 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
| EP3191592A1 (en) * | 2014-09-11 | 2017-07-19 | Novartis AG | Inhibition of prmt5 to treat mtap-deficiency-related diseases |
| TW202122387A (zh) | 2019-09-12 | 2021-06-16 | 美商米瑞替療法公司 | Mta協同性之prmt5抑制劑 |
| AU2020410418A1 (en) * | 2019-12-18 | 2022-06-09 | Pfizer Inc. | Once daily cancer treatment regimen with a PRMT5 inhibitor |
| WO2021138578A1 (en) * | 2019-12-31 | 2021-07-08 | The Trustees Of Indiana University | Repurposing fda-approved drugs as a novel cancer therapeutic avenue through inhibition of prmt5 |
-
2022
- 2022-10-06 EP EP22800027.9A patent/EP4412607A1/en active Pending
- 2022-10-06 AU AU2022360837A patent/AU2022360837A1/en active Pending
- 2022-10-06 CA CA3233157A patent/CA3233157A1/en active Pending
- 2022-10-06 MX MX2024004171A patent/MX2024004171A/es unknown
- 2022-10-06 US US18/697,932 patent/US20240398795A1/en active Pending
- 2022-10-06 JP JP2024521023A patent/JP2024538719A/ja active Pending
- 2022-10-06 WO PCT/US2022/045895 patent/WO2023059795A1/en not_active Ceased
- 2022-10-06 KR KR1020247014554A patent/KR20240095421A/ko active Pending
- 2022-10-06 IL IL311663A patent/IL311663A/en unknown
- 2022-10-06 CN CN202280067397.9A patent/CN118251218A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2024538719A (ja) | 2024-10-23 |
| CA3233157A1 (en) | 2023-04-13 |
| CN118251218A (zh) | 2024-06-25 |
| MX2024004171A (es) | 2024-04-23 |
| EP4412607A1 (en) | 2024-08-14 |
| WO2023059795A1 (en) | 2023-04-13 |
| AU2022360837A1 (en) | 2024-04-18 |
| KR20240095421A (ko) | 2024-06-25 |
| US20240398795A1 (en) | 2024-12-05 |
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