IL308917A - A method for preparing a radiolabeled [18F] compound with low water content during the labeling step - Google Patents

A method for preparing a radiolabeled [18F] compound with low water content during the labeling step

Info

Publication number
IL308917A
IL308917A IL308917A IL30891723A IL308917A IL 308917 A IL308917 A IL 308917A IL 308917 A IL308917 A IL 308917A IL 30891723 A IL30891723 A IL 30891723A IL 308917 A IL308917 A IL 308917A
Authority
IL
Israel
Prior art keywords
preparing
water content
low water
content during
radiolabelled compound
Prior art date
Application number
IL308917A
Other languages
English (en)
Hebrew (he)
Inventor
Torgrim Engell
Graeme Mcrobbie
Alan Clarke
Julian Grigg
Imtiaz Ahmed Khan
Kristine Wikene
Jonathan Shales
Alexander Jackson
Original Assignee
Ge Healthcare Ltd
Torgrim Engell
Graeme Mcrobbie
Alan Clarke
Julian Grigg
Imtiaz Ahmed Khan
Kristine Wikene
Jonathan Shales
Alexander Jackson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ge Healthcare Ltd, Torgrim Engell, Graeme Mcrobbie, Alan Clarke, Julian Grigg, Imtiaz Ahmed Khan, Kristine Wikene, Jonathan Shales, Alexander Jackson filed Critical Ge Healthcare Ltd
Publication of IL308917A publication Critical patent/IL308917A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0453—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0463—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0491—Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0493—Steroids, e.g. cholesterol, testosterone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/001—Acyclic or carbocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/004—Acyclic, carbocyclic or heterocyclic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur, selenium or tellurium
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/005—Sugars; Derivatives thereof; Nucleosides; Nucleotides; Nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/007—Steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL308917A 2021-06-16 2022-06-16 A method for preparing a radiolabeled [18F] compound with low water content during the labeling step IL308917A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB2108605.3A GB202108605D0 (en) 2021-06-16 2021-06-16 Effect of water content
PCT/EP2022/066483 WO2022263594A1 (en) 2021-06-16 2022-06-16 Method for preparing an [18f] radiolabelled compound with low water content during labelling step

Publications (1)

Publication Number Publication Date
IL308917A true IL308917A (en) 2024-01-01

Family

ID=76954450

Family Applications (1)

Application Number Title Priority Date Filing Date
IL308917A IL308917A (en) 2021-06-16 2022-06-16 A method for preparing a radiolabeled [18F] compound with low water content during the labeling step

Country Status (12)

Country Link
US (2) US20240366808A1 (enExample)
EP (1) EP4355715A1 (enExample)
JP (1) JP2024522770A (enExample)
KR (1) KR20240021888A (enExample)
CN (1) CN117500773A (enExample)
AU (1) AU2022294052A1 (enExample)
BR (1) BR112023026514A2 (enExample)
CA (1) CA3223802A1 (enExample)
GB (1) GB202108605D0 (enExample)
IL (1) IL308917A (enExample)
MX (1) MX2023015076A (enExample)
WO (1) WO2022263594A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201915206D0 (en) 2019-10-21 2019-12-04 Ge Healthcare Ltd Use of cyclodextrins as a radiostabilizer

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0520527D0 (en) 2005-10-10 2005-11-16 Ge Healthcare Ltd Automated method
EP2053033A1 (en) * 2007-10-26 2009-04-29 Bayer Schering Pharma AG Compounds for use in imaging, diagnosing and/or treatment of diseases of the central nervous system or of tumors
DK3323810T3 (da) 2010-02-08 2022-03-28 Lantheus Medical Imaging Inc Automatiseret reaktionssystem, kassette og indretning til syntese af billeddannelsesmidler
EP2657213A1 (en) * 2012-04-24 2013-10-30 Institut National de la Santé et de la Recherche Medicale Labelled quinoxaline derivatives as multimodal radiopharmaceuticals and their precursors
EP2880005B1 (en) * 2012-07-30 2016-05-25 Technical University of Denmark Radiofluorination method
CN107207379B (zh) * 2014-11-25 2021-08-10 百时美施贵宝公司 用于生物制品的18f-放射性标记的方法和组合物
EP3423113B1 (en) * 2016-02-29 2020-09-02 Oncodesign S.A. Radiolabeled macrocyclic egfr inhibitor
US11583596B2 (en) * 2017-09-26 2023-02-21 Inserm (Institut National De La Sante Et De La Recherche Medicale) Radiolabeled Darapladib and analogs thereof and their use as imaging compounds

Also Published As

Publication number Publication date
KR20240021888A (ko) 2024-02-19
US20240366808A1 (en) 2024-11-07
AU2022294052A1 (en) 2023-12-14
CN117500773A (zh) 2024-02-02
JP2024522770A (ja) 2024-06-21
WO2022263594A1 (en) 2022-12-22
MX2023015076A (es) 2024-01-18
CA3223802A1 (en) 2022-12-22
BR112023026514A2 (pt) 2024-03-05
GB202108605D0 (en) 2021-07-28
EP4355715A1 (en) 2024-04-24
US20250312494A1 (en) 2025-10-09

Similar Documents

Publication Publication Date Title
GB201019407D0 (en) System and method for depth measurement and correction during subsea intervention operations
IL308917A (en) A method for preparing a radiolabeled [18F] compound with low water content during the labeling step
NZ595227A (en) Tricyclic indole derivates as pbr ligands
IL194735A (en) METHOD FOR SELECTING Stereo Selection of Morphinone History
WO2007064819A3 (en) Devices, systems, and methods for occluding a defect
ZA201100683B (en) Apparatus,method and system for creating,collecting and indexing seed portions from individiual seed
GB2462602B (en) Method and apparatus for towing offshore wind turbines
MX2010001555A (es) Metodos y sistemas para instalar cable para medir un parametro fisico.
WO2010077572A3 (en) Method and system of selecting word sequence for text written in language without word boundary markers
IL203316A (en) Radioactive Pharmaceutical Composition Containing Radioactive Benzothiazole Compound and Carried Biologically, Method of Preparation and Method of Imaging by Using It
CA2720430C (en) Underwater drilling arrangement and method for introducing a tubular foundation element into the bed of a body of water
HK40108896A (en) Method for preparing an [18f] radiolabelled compound with low water content during labelling step
ZA202109796B (en) System and method for preparing methanol therewith
IL179107A0 (en) Method for preparing n-piperidino-1,5-diphenylpyrazole-3-carboxamide derivatives
GB202310058D0 (en) Method for preparing ternary precursor
EG24393A (en) Method for producing 4-nitroimidazole compound
ZA201005566B (en) Method for producing isothiocyanate compound having carboxyl group
ZA200608925B (en) Method for safely logging onto a technical system
GB202306808D0 (en) Method for detecting interactions
GB2398467B (en) Method for reconstructing multimedia object data by means of digital-audio-broadcast (DAB) receivers
PT1794152E (pt) Método para a produção de compostos de imidazol enantioméricos
ZA202302732B (en) Method for preparing 4-aminonaphthalene-2,6-dicarboxylic acid
SI4178969T1 (sl) Postopek za pripravo diosmina
GB2634158B (en) Offshore anchoring methods
GB202113646D0 (en) Method of preparation of 18F labelled silyl-fluoride compounds