IL308028A

IL308028A - Dosing system for adjusting a dosing volume of a flowable medium, and syringe adapter as a component of such a dosing system

Info

Publication number: IL308028A
Application number: IL308028A
Authority: IL
Original assignee: Raumedic Ag
Priority date: 2021-04-30
Filing date: 2022-04-07
Publication date: 2023-12-01
Also published as: DE102021204338A1; WO2022228848A1; CN117677415A; EP4329845A1

Description

DOSING SYSTEM FOR ADJUSTING A DOSING VOLUME OF A FLOWABLE ME-DIUM, AND SYRINGE ADAPTER AS A COMPONENT OF SUCH A DOSING SYS-TEM The invention relates to a dosing system for adjusting a dosing volume of a flowable medium. The invention furthermore relates to a syringe adapter as a component part of such a dosing system. A dosing system of the kind mentioned at the beginning is known from EP 2 801 3B1. A syringe adapter of the kind mentioned at the beginning is known from EP 2 985 015 B1. EP 1 324 794 B1 discloses an adjustable dosing syringe. US 1,638,5discloses various syringe head designs. US 4,275,729 discloses an adjustable dos-ing syringe. US 2014/0 014 547 A1 discloses a medication container. It is an object of the present invention to further develop a dosing system of the type mentioned at the beginning in such a way that the risk of incorrect operation is re-duced. This object is achieved according to the invention by a dosing system having the features indicated in claim 1. By providing at least one rib on the external shell or lateral wall of the syringe cone, it is achieved that the latter no longer fits female luer connections. Undesirable uses of the dosing syringe of the dosing system with female luer components, for which the dosing syringe is not intended, are not possible then. The rib can be integrally molded to the syringe cone. The external lateral wall of the syringe cone may have more than one such rib, for example two ribs, three ribs, four ribs, or still more ribs. As a rule, the external lateral wall of the syringe cone has less than 10 such ribs. A maximum adjustable dosing volume of the dosing syringe may be less than 50 ml, may be less than 25 ml, and may be less than 20 ml. The maximum adjustable dosing volume may be in the range of 10 ml, in the range of 5 ml, in the range of 2.ml, or in the range of 1.0 ml. The dosing volume may be adjustable with an accuracy of 0.1 ml.

The dosing system may be made of plastics as a whole. An axial rib according to claim 2 has been proven to prevent an undesirable connec-tion to a female luer connector. The dosing syringe, on the syringe cone, may be provided with a plurality of axial ribs distributed in the circumferential direction about the central longitudinal axis, and in particular uniformly distributed, for example two, three, four, five or still more axial ribs. The number of such axial ribs is regularly less than 10. A rib height according to claim 3 has been proven to avoid an undesirable connection to a female luer connector. The rib height may be in the range between 0.3 mm and 0.6 mm and in the range between 0.4 mm and 0.5 mm. A syringe adapter according to claim 4 ensures a secure seal of the fluid channel with respect to the syringe body of the dosing syringe in the region of the syringe cone despite the presence of the rib. For this purpose, the silicone sleeve portion has sufficient flexibility to compensate for radial steps formed by the at least one rib. A diameter relation according to claim 5 results in a secure seal of the main cone surface of the syringe cone of the dosing syringe at the level of the at least one rib with respect to the fluid channel. The difference between the minimum outer diame-ter of the main cone surface at the level of the at least one rib and the internal diam-eter of the fluid channel may be greater than 0.1 mm, may be greater than 0.2 mm, and may be in the range of 0.3 mm. This difference is regularly less than 0.5 mm or less than 1.0 mm. A silicone circumferential lip according to claim 6 results in particularly secure seal-ing of the fluid channel with respect to the syringe cone in the region of the at least one rib. The internal diameter of the fluid channel can be at least 5% smaller in the region of the silicone circumferential lip than in an axially adjacent region of the fluid channel. This ensures that a seal is actually created by the silicone circumferential lip. A design of the syringe adapter according to claim 7 is stable despite the use of a soft silicone inlay.

This holds in particular for a syringe adapter having a locking body according to claim 8. A ventilation channel according to claim 9 allows safe receiving of flow blanket me-dium to be dosed from the container and/or safe dispensing of the medium into the container. A further object of the invention is to provide a syringe adapter for a dosing system for adjusting a dosing volume of a flowable medium, in which a secure seal of the fluid channel with respect to an external lateral wall of the dosing syringe of the dosing system is provided. This object is achieved according to the invention by means of a syringe adapter having the features indicated in claim 10. The advantages of the syringe adapter according to claims 10 and 11 correspond to those already explained above in connection in particular with claims 4 to 9. The syringe adapter may have arbitrary additional features or feature combinations of these claims. For example, the internal diameter of the fluid channel in the region of the silicone circumferential lip may be at least 5% smaller than in an axially adja-cent region of the fluid channel. Embodiments of the invention will be explained in more detail in the following with reference to the drawings, in which: Fig. 1 shows a perspective view of a dosing syringe of a dosing system for adjust-ing a dosing volume of a flowable medium, using an adjustable maximum dosing volume of 10 ml as an example. Fig. 2 shows another perspective view of the dosing syringe from the opposite di-rection compared to Fig. 1; Fig. 3 shows an end face view of the dosing syringe from viewing direction III in Fig. 1; Fig. 4 shows an axial longitudinal cross-sectional view according to line IV-IV in Fig. 3; Fig. 5 shows a perspective view of a syringe body of the dosing syringe according to Fig. 1; Fig. 6 shows an end face view of the syringe body from viewing direction VI in Fig. 5; Fig. 7 shows a side view of the syringe body shown partially broken up in an axial cross-sectional view, as seen from viewing direction VII in Fig. 5; Fig. 8 shows a cross-sectional view according to line VIII-VIII in Fig. 7; Fig. 9 shows an enlarged view of detail IX in Fig. 7; Fig. 10 shows, in a view similar to Fig. 1, the dosing syringe during application of an adhesive label prepared in the manner of a band label; Fig. 11 shows a perspective view of a dosing plunger of the dosing syringe accord- ing to Fig. 1; Fig. 12 shows a side view of the dosing plunger as seen from viewing direction XII in Fig. 11; Fig. 13 shows a perspective view of a stop element of a stop means of the dosing syringe for adjustable delimitation of a stroke of the dosing plunger in the syringe body, in a completely assembled state; Fig. 14 shows the stop element according to Fig. 13 in an unfolded state; Fig. 15 shows a perspective view of a latching element of the stop means of the dosing syringe; Fig. 16 shows a perspective view of a syringe adapter of the dosing system for seal- ingly connecting the dosing syringe to a container for receiving or dispens-ing the medium; Fig. 17 shows an axial cross-sectional view according to line XVII-XVII in Fig. 16; Fig. 18 shows a view of an adapter housing of the syringe adapter according to Fig. 16, as seen from viewing direction XVIII in Fig. 16; Fig. 19 shows a cross-sectional view of the adapter housing according to line XIX-XIX in Fig. 18; Fig. 20 shows a perspective view of a locking body of the syringe adapter in an installation situation, as seen from the same viewing direction as in Fig. 16; Fig. 21 shows a cross-sectional view according to line XXI-XXI in Fig. 20; Fig. 22 shows a perspective view of a silicone inlay of the syringe adapter according to Fig. 16, again in an installation orientation as in Fig. 16; Fig. 23 shows a perspective view of the silicone inlay from the opposite viewing direction compared to Fig. 22; Fig. 24 shows an axial cross-sectional view of the silicone inlay according to line XXIV-XXIV in Fig. 22; Fig. 25 shows the detail XXV in Fig. 24; Fig. 26 shows a further embodiment of a dosing syringe, in an illustration similar to Fig. 1, designed for a maximum dosing volume of 5 ml; Fig. 27 shows the dosing syringe according to Fig. 26 in an illustration similar to Fig. 2; Fig. 28 shows the dosing syringe according to Fig. 26 in an illustration similar to Fig. 3; Fig. 29 shows a cross-sectional view according to line XXIX-XXIX in Fig. 28; Fig. 30 shows a further embodiment of a dosing syringe in an illustration similar to Fig. 1, designed for a maximum dosing volume of 2.5 ml; Fig. 31 shows the dosing syringe according to Fig. 30 in an illustration similar to Fig. 2. Fig. 32 shows the dosing syringe according to Fig. 30 in an illustration similar to Fig. 3; Fig. 33 shows a cross-sectional view according to line XXXIII-XXXIII in Fig. 32; Fig. 34 shows a further embodiment of a dosing syringe in an illustration similar to Fig. 1, designed for a maximum dosing volume of 1.0 ml; Fig. 35 shows the dosing syringe according to Fig. 34 in an illustration similar to Fig. 2; Fig. 36 shows the dosing syringe according to Fig. 34 in an illustration similar to Fig. 3; Fig. 37 shows a cross-sectional view according to line XXXVII-XXXVII in Fig. 36; Fig. 38 shows a perspective view of the syringe body of the dosing syringe accord-ing to Fig. 35 in an illustration similar to Fig. 5; Fig. 39 shows an end face view of the syringe body from viewing direction XXXIX in Fig. 38; Fig. 40 shows a side view of the syringe body, partially broken up in an axial cross-sectional view, as seen from viewing direction XL in Fig. 38; Fig. 41 shows a cross-sectional view according to line XLI-XLI in Fig. 38; Fig. 42 shows detail XLII in Fig. 38 in enlarged form; Fig. 43 shows a perspective view of a dosing plunger of the dosing syringe accord-ing to Fig. 34; Fig. 44 shows a side view of the dosing plunger as viewed from viewing direction XLIV-XLIV in Fig. 43. An embodiment of a dosing system for setting or adjusting a dosing volume of a flowable medium will be described in the following by way of Figs. 1 to 25. The main components of the dosing system are a dosing syringe 1 (cf. for example Fig. 1) and a syringe adapter 2 (cf. Figs. 16 and 17). The dosing syringe 1 and the syringe adapter 2 are made of plastics as a whole. The dosing syringe 1 has a syringe body 3, which is shown as a single component in Figs. 5 to 8, and a dosing plunger 4, which is shown as a single component in Figs. 11 and 12. The syringe body 3 is made of polypropylene. The dosing plunger is made of polyethylene. In the embodiment shown, the dosing syringe 1 serves to preset a maximum dosing volume of 10 ml. For adjustable limitation of a stroke of the dosing plunger 4 in the syringe body 3, which takes place along a central longitudinal axis 5 of the dosing syringe 1 (cf. Fig.4), there is used a stop means 6. The latter comprises a draw-up limiting element (cf. for example Fig. 15) for limiting a maximum draw-up path of the dosing plunger in the direction of the central longitudinal axis 5 and a stop 8 (cf. in particular Figs. and 14) against which the draw-up limiting element 7 abuts in a drawn-up position of the dosing plunger 4. The draw-up limiting element 7 is also referred to as a latch-ing element. The basic mode of operation of an embodiment of the stop means 6 is known from DE 2 801 382 B1. The stop 8 has a sleeve-shaped basic shape and has two circumferential halves 8a, 8b, which are connected to one another via joint lugs 8c in such a way that a joint connection of the two circumferential halves 8a, 8b about a joint axis 8d results. When the stop 8 is mounted, the joint axis 8d extends at a distance parallel to the central longitudinal axis 5 of the dosing syringe 1. This joint design of the stop allows the two circumferential halves 8a, 8b of the stop 8 to be manufactured in one manufacturing process and, in particular, to be molded in one injection molding step. When assembling the stop 8, the latter is placed around a plunger rod of the dosing plunger 4 in the initially open position according to Fig. 14 and then the stop is trans-ferred to the closed position according to Fig. 13, in which the two circumferential halves 8a, 8b are latchingly connected to each other and are positively connected to the syringe body 3 via snap-in hooks projecting radially on the outside. In the illustration according to Fig. 4, for example, the draw-up limiting element is in its radially outer position before the dosing volume is preset by cooperation of a form-fitting means 9 of the draw-up limiting element 7 with exactly one form-fitting receptacle or recess of a plurality of form-fitting recesses 10 in an external lateral or shell wall of the dosing plunger 4. In this radially outer position of the draw-up limiting element 7, the form-fitting means is disengaged from the form-fitting recesses 10. For clarification of a dosing quantity, a dosing scale 11 (cf. Fig. 1) is printed on the syringe body 3. This print is made by a pad printing method. For avoiding operating errors, the draw-up limiting element 7 is covered by a band label 12 in the radially outer initial position according to Fig. 4. This band label has a peel-off tab 13 in the applied position (cf. Fig. 1). The latter carries informative printing, which is visible as indicated in Fig. 2. Fig. 10 shows a snapshot during final assembly of the dosing syringe 1 when the band label 12 is applied. A circumferential orientation of the band label 12 with re-spect to a circumferential position of the draw-up limiting element 7 is such that an adhesive surface 14 of the band label 12 does not lie on the draw-up limiting element 7. The syringe body 3 has an integrally molded circumferential collar 15 which forms two operating wings. The dosing plunger 4 in turn has a round circumferential collar at the end side, where it projects beyond the syringe body 3. The two circumfer-ential collars 15, 16 permit simple handling of the dosing syringe 1 for drawing up the dosing plunger 4 and for pushing the dosing plunger 4 into the syringe body 3. For simplified handling of the dosing syringe 1 when drawing up the dosing plunger 4, there is provided furthermore a corrugation of an end surface of the circumferen-tial collar 15 of the syringe body 3, which is visible, for example, in the viewing di-rections of Figures 2 and 5.

The syringe body 3 has a syringe cone 17 on the dispensing or end side. The syringe cone 17 (cf. in particular Figs. 1 and 9) delimits a dispensing opening 18 of the sy-ringe body 3 for the medium to be dosed. An external lateral wall 19 of the syringe cone 17 has at least one rib 20 designed as an axial rib, which is raised above a main cone surface 21 of the external lateral wall 19 by a radial rib height RH (cf. Fig. 9). The dosing syringe 1 of the embodiment according to Figs. 1 to 15 has a total of three such ribs 20a, 20b, 20c (cf. for example Fig. 6), which are raised radially in the same manner above the main cone surface 21 of the syringe cone 17. These three axial ribs 20a to 20c (=20i) are uniformly distributed in the circumferential direction around the central longitudinal axis 5 of the syringe body 3. Depending on the design of the syringe body, a different number of ribs 20i may also be provided, for example two to ten such ribs 20i (two ribs, four ribs, five ribs, six ribs, seven ribs, eight ribs, nine ribs, ten ribs). The rib height RH in the embodiment illustrated is about 0.5 mm and can be in the range between 0.2 mm and 0.8 mm, in the range between 0.3 mm and 0.6 mm, in the range between 0.4 mm and 0.5 mm and also in the range around 0.4 mm. An outer diameter of the syringe cone 17 in the region of the ribs 20 can be at max- imum in the range between 5.7 and 6.0 mm. In the area between the ribs 20, the outer diameter of the syringe cone at the axial height of the ribs 20 can be in the range between 5.4 mm and 5.7 mm. The syringe adapter 2 will be explained in more detail below with reference to Figs. 16 to 25. The syringe adapter 2 has a fluid channel 24 for creating a flow connection between an interior of a container 25 shown in section in Fig. 17 and an interior of the syringe body 3, in particular the dispensing opening 18 of the syringe cone 17. An internal diameter of the fluid channel 24 is delimited by a sleeve portion 26 made of silicone. Via this sleeve portion 26, the syringe cone 17 sealingly abuts the fluid channel in a connecting adaptation position, the sleeve portion 26 providing for a seal with respect to the syringe cone 17 also in the region of the ribs 20i, in particular in the region of the radial steps formed by the ribs 20i.

The sleeve portion 26 is part of a silicone inlay 27, which is shown in its entirety in Figs. 22 and 23, for example. The silicone inlay 27 is inserted into an adapter hous-ing 28 of the syringe adapter 2. A locking body 29 serves to hold the silicone inlay in the adapter housing 28. The adapter housing 28 is shown as a single compo-nent in Figs. 18 and 19. The locking body 29 is shown as a single component in Figs. 20 and 21. The silicone material of the silicone inlay 27 has a Shore A hardness of 40. Alterna-tively, there may be provided a different Shore A hardness in the range between and 50 and in particular in the range between 35 and 45. The silicone material of the silicone inlay 27 includes as component A a polydimethylsiloxane with vinyl groups and at least one auxiliary agent, and as component B a polydimethylsiloxane with functional groups and at least one auxiliary agent. The adapter housing 28 is made of polyethylene, in particular LDPE (low-density polyethylene). The locking body 29 is made of polypropylene. In the assembled position, the locking body 29 latchingly engages a circumferential latching receptacle or recess 29a in an internal shell wall of the adapter housing 28. In addition to the fluid channel 24, the syringe adapter 2 also has a ventilation chan-nel 30 for providing air communication between the interior of the container 25 and a container environment 31 (cf. Fig. 17). A basic structure of such a syringe adapter with a fluid channel and at least one ventilation channel is known from EP 2 985 015 B1. The ventilation channel 30 includes a check valve 32 configured as a beak valve, which provides a direction of ventilation from the container environment 31 into the interior of the container 25 through the ventilation channel 30. The check valve 32 is an integral part of the silicone inlay 27. Both the fluid channel 24 and the ventilation channel 30 have three channel portions 24a, 24b, 24c, 30a, 30b, 30c extending from the container environment 31 toward the interior of the container 25, which are formed in this order in the adapter housing 28, the silicone inlay 27, and the locking body 29.

In the sleeve portion 26, an internal diameter ID of the fluid channel 24 is defined by a silicone circumferential lip 33 of the sleeve portion 26 of the silicone inlay 27. The internal diameter ID of the fluid channel 24 is at least 5% smaller in the region of this silicone circumferential lip 33 than in an axially adjacent region of the fluid channel 24, and in particular at least 5% smaller than in the axially adjacent region of the sleeve portion 26. The internal diameter ID of the silicone inlay 27 is in the range between 5.0 mm and 5.2 mm and may be, for example, 5.1 mm. To prevent rotation of a circumferential orientation of the silicone inlay 27 in the adapter housing 28, the silicone inlay has external axial grooves 34 which, when the silicone inlay 27 is mounted, cooperate with complementary axial ribs 35 (cf. Fig. 18) of the adapter housing 28. The axial grooves 34 and the axial ribs 35 are distrib-uted in the circumferential direction such that only exactly one circumferential orien- tation of the silicone inlay 27 in the adapter housing is possible. Circumferential lugs 36, which are integrally formed on the outside of the locking body 29 and cooperate with corresponding circumferential recesses 36a in the inte-rior shell wall of the adapter housing 28, serve for corresponding circumferential positioning and rotation-preventing locking of the locking body 29 relative to the adapter housing 28 and the silicone inlay 27. Initially, the fluid channel 24 is closed by means of a predetermined breaking skin of the silicone inlay 27, which is pierced when the syringe cone 17 enters the fluid channel 24. The predetermined breaking skin 37 is supported by four quadrant-shaped supporting tabs 38 of the silicone inlay 27, which flip out toward the container when the syringe cone 17 is pierced, thereby releasing the fluid channel 24. The dosing system is prepared and used as follows: First, the dosing syringe 1 and the syringe adapter 2 are assembled, resulting in the initial configurations shown in particular in Figs. 4 (dosing syringe 1) and 17 (syringe adapter 2). When assembling the syringe adapter 2, the silicone inlay 27 is inserted into the adapter housing 28 and positioned via the mating axial grooves 34 and axial ribs 35. Thereafter the locking body 29 is inserted into the adapter housing 28 and positioned via the mating circumferential lugs 36 and circumferential recesses 36a, and latchingly engaged in the latching recess 29a. The check valve 32 is made operable by piercing it once. To adjust a dosing volume, the band label 12 is first removed from the syringe body 3 via the pull-off tabs 13, and the dosing plunger 4 is then drawn up as far as the desired dosing volume re-quires. In this position, the draw-up limiting element 7 is then displaced radially in-wards so that the form-fitting means 9 cooperates with and engages in the form-fitting recess 10 desired for adjustment. Now the dosing plunger can again be pushed completely into the syringe body 7, and the dosing syringe is inserted with the syringe cone 17 into the liquid channel 24 of the syringe adapter 2. The assembled syringe adapter 2 is then placed on the container with the medium to be dosed. When the syringe cone 17 is inserted into the fluid channel 24, the predetermined breaking skin 37 is pierced and the syringe cone 17 comes to axially abut in the fluid channel 24 in such a way that the axial ribs 20i come to lie at the level of the silicone circumferential lip 33 of the sleeve portion 26 of the silicone inlay 27. The soft silicone circumferential lip 33 provides for sufficient radial circumferential compensation so that the silicone circumferential lip 33 seals against the external lateral wall 19 of the syringe cone 17 across the entire circumference despite the axial ribs 20i. In this sealing position, the dosing plunger 4 in the syringe body 3 can now be drawn up to the predetermined dosing stop, whereby the dosing syringe 1 is filled with the preset dosing volume of the flowable medium. Here, the ventilation channel 30 provides for ventilation of the interior of the container 25 to compensate for the dosing volume withdrawn. The internal diameter ID of the fluid channel 24 is smaller than a minimum external diameter ADmin (cf. Fig. 9) of the main cone surface 21 at the level of the at least one rib. This diameter difference ADmin - ID is greater than 0.1 mm. Depending on the design of the syringe cone 17 and the sleeve portion 26 of the syringe adapter 2, this diameter difference may be greater than 0.2 mm, may be greater than 0.3 mm and may be still greater. This diameter difference is on a regular basis smaller than 1.0 mm.

With reference to Figs. 26 to 29, a further embodiment of a dosing syringe 40 will be described below, which is used instead of the dosing syringe 1 for adjusting a dosing volume up to a maximum of 5 ml. Components and functions corresponding to those already described above with reference to Figs. 1 to 25 bear the same reference numerals and will not be discussed in detail again. In accordance with the smaller maximum dosing volume, a cylinder volume of a syringe body 3 of the dosing syringe 40 is smaller compared to that of the dosing syringe 1. An external diameter of a dosing plunger 4 is adapted to a correspondingly reduced internal diameter of the syringe body 3 of the dosing syringe 40. With reference to Figs. 30 to 33, a further embodiment of a dosing syringe 41 will be described in the following, which is used instead of the dosing syringe 1 for adjusting a dosing volume up to a maximum of 2.5 ml. Components and functions correspond-ing to those already described above with reference to Figs. 1 to 25 bear the same reference numerals and will not be discussed in detail again. In accordance with the smaller maximum dosing volume, a cylinder volume of a syringe body 3 of the dosing syringe 41 is smaller compared to that of the dosing syringe 1. An external diameter of a dosing plunger 4 is adapted to a correspondingly reduced internal diameter of the syringe body 3 of the dosing syringe 41. Moreover, in the case of the dosing syringe 41, a draw-up stroke of the dosing plunger 4 in the syringe body 3 is limited. This follows by a corresponding arrange-ment of the form-fitting recesses 10 on the dosing plunger 4. With reference to Figs. 34 to 44, a further embodiment of a dosing syringe 42 will be described in the following, which is used instead of the dosing syringe 1 for adjusting or setting a dosing volume up to a maximum of 1.0 ml. Components and functions corresponding to those already described above with reference to Figs. 1 to 25 bear the same reference numerals and will not be discussed in detail again. In the dosing syringe 42, both the syringe body 3 and the dosing plunger 4 are axially divided into a volume section 3a/4a and a dosing section 3b/4b formed thereon. The volume sections 3a and 4a of the syringe body and the dosing plunger 4 serve to limit the dosing volume for the flowable medium. The dosing sections 3b and 4b of the syringe body 3 and the dosing plunger 4 serve to adjust the dosing volume.

Between the volume section 3a and the dosing section 3b, the syringe body 3 has a circumferential step 43, via which it tapers towards the volume section 3a. A diam-eter of the dosing section 3b is comparable to that of the syringe bodies 3 of, for example, dosing syringes 40 and 41, so that the stop means 6 in particular can be accommodated there. In comparison, the internal diameter of the syringe body 3 is tapered in the volume section 3a in order to achieve a corresponding dosing accu-racy with the smaller maximum dosing volume of 1.0 mm. With the dosing syringe 42, the stop means 6 has exactly nine form-fitting recesses 10, via which accuracy of adjustment of the dosing volume of 0.1 ml is achieved. In the dosing plunger 4 of the dosing syringe 42, the volume section 4a merges into the dosing section 4b via a circumferential step 44. The volume section 4a has a tip-side end portion 45 which, when the dosing plunger 4 is pushed out completely, comes to lie in the inner volume of the syringe cone 17 of the volume section 3a of the syringe body 3. Between a main portion 46 of the volume section 4a and the tip-side end portion 45, the dosing plunger 4 of the dosing syringe 42 has a sealing portion 47 designed as a circumferential collar for sealing against an inner wall of the volume section 3a of the syringe body 3. The main portion 46 of the volume section 4a of the dosing plunger 4 of the dosing syringe 42 has a cruciform cross-section. A radial extension of cross-ribs 48 of the main portion 46 tapers adjacent to the sealing portion 47 via a respective rib step 49. The rib steps 49 serve to free the sealing portion 47 from static influences of the cross-ribs 48. In the region of the circumferential step 44, the dosing plunger 4 has a further cir-cumferential collar 50 which serves to guide the stroke of the dosing plunger 4 by cooperating with the inner wall of the dosing section 3b of the syringe body 3. The syringe adapter 2 is designed to cooperate with any of the embodiments of the dosing syringes 1, 40, 41, 42 described hereinbefore.

Claims

1.C l aim s 1. A dosing system for adjusting a dosing volume of a flowable medium, comprising a dosing syringe (1; 40; 41; 42) - having a syringe body (3) and a dosing plunger (4), - having a stop means (6) for adjustably limiting a stroke of the dosing plunger (4) in the syringe body (3), which takes place along a central longitudinal axis (5) of the dosing syringe (1; 40; 41, 42), - wherein the syringe body (3) has an end-face syringe cone (17) with a dispensing opening (18) for the medium to be dosed, - wherein an external lateral wall (19) of the syringe cone (17) comprises at least one rib (20) which is raised above a main cone surface (21) of the external lateral wall (19) by a radial rib height (RH).

2. The dosing system according to claim 1, characterized in that the at least one rib (20) is designed as an axial rib.

3. The dosing system according to claim 1 or 2, characterized by a rib height (RH) in the range between 0.2 mm and 0.8 mm.

4. The dosing system according to any of claims 1 to 3, characterized by a syringe adapter (2) for sealingly connecting the dosing syringe (1; 40; 41; 42) to a container (25) for receiving or dispensing the medium, - wherein the syringe adapter (2) comprises a fluid channel (24) for providing a flow connection between an interior of the container (25) and an interior of the syringe body (3), - wherein the fluid channel (24) is delimited by a sleeve portion (26) of silicone.

5. The dosing system according to claim 4, characterized in that an internal diameter (ID) of the liquid channel (24) is smaller than a minimum external diameter (AD min) of the main cone surface (21) at the level of the at least one rib (20).

6. The dosing system according to claim 4 or 5, characterized in that the internal diameter (ID) of the liquid channel (24) is delimited by a silicone circumferential lip (33) of the sleeve portion (26).

7. The dosing system according to any of claims 4 to 6, characterized in that the syringe adapter (2) comprises an adapter housing (28) for insertion into a recess of the container (25), wherein the silicone sleeve section (26) is part of a silicone inlay (27) which is inserted into the adapter housing (28).

8. The dosing system according to claim 7, characterized in that the syringe adapter (2) comprises a locking body (29) for retaining the silicone inlay (27) in the adapter housing (28).

9. The dosing system according to any of claims 4 to 8, wherein the syringe adapter (2) comprises at least one ventilation channel (30) for providing an air connection between the interior of the container (25) and a container environment (31).

10. A syringe adapter (2) as a component part of a dosing system comprising a dosing syringe (1; 40; 41; 42) for adjusting a dosing volume of a flowable medium, wherein the syringe adapter (2) is designed for connecting the dosing syringe (1; 40; 41; 42) to a container (25) for receiving or dispensing the medium, - comprising a fluid channel (24) for providing a flow connection between an interior of the container (25) and an interior of the syringe body (3), - wherein the fluid channel (24) is delimited by a sleeve portion (26) of silicone, - wherein an internal diameter (ID) of the fluid channel (24) is delimited by a silicone circumferential lip (33) of the sleeve portion (26).

11. The syringe adapter according to claim 10, characterized in that the silicone circumferential lip (33) for sealing the liquid channel (24) with respect to the syringe body (3) of the dosing syringe (1; 40; 41; 42) is formed in the region of a syringe cone (17) of the dosing syringe (1; 40; 41; 42). For the Applicant WOLFF, BREGMAN AND GOLLER By: