IL307671B2 - רשתות נויראליות עמוקות לניבוי פתוגניות של וריאנטים באמצעות מבני חלבון תלת מימדיים (3d) - Google Patents

רשתות נויראליות עמוקות לניבוי פתוגניות של וריאנטים באמצעות מבני חלבון תלת מימדיים (3d)

Info

Publication number
IL307671B2
IL307671B2 IL307671A IL30767123A IL307671B2 IL 307671 B2 IL307671 B2 IL 307671B2 IL 307671 A IL307671 A IL 307671A IL 30767123 A IL30767123 A IL 30767123A IL 307671 B2 IL307671 B2 IL 307671B2
Authority
IL
Israel
Prior art keywords
amino acid
amino acids
atom
nearest
voxel
Prior art date
Application number
IL307671A
Other languages
English (en)
Other versions
IL307671A (he
IL307671B1 (he
Original Assignee
Illumina Inc
Illumina Cambridge Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US17/232,056 external-priority patent/US12217829B2/en
Priority claimed from US17/703,935 external-priority patent/US12444482B2/en
Application filed by Illumina Inc, Illumina Cambridge Ltd filed Critical Illumina Inc
Publication of IL307671A publication Critical patent/IL307671A/he
Publication of IL307671B1 publication Critical patent/IL307671B1/he
Publication of IL307671B2 publication Critical patent/IL307671B2/he

Links

Classifications

    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/20—Supervised data analysis
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B50/00—ICT programming tools or database systems specially adapted for bioinformatics

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Medical Informatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biotechnology (AREA)
  • Evolutionary Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Theoretical Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Data Mining & Analysis (AREA)
  • Databases & Information Systems (AREA)
  • Bioethics (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Artificial Intelligence (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Evolutionary Computation (AREA)
  • Public Health (AREA)
  • Software Systems (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Management, Administration, Business Operations System, And Electronic Commerce (AREA)
  • Information Retrieval, Db Structures And Fs Structures Therefor (AREA)
  • Peptides Or Proteins (AREA)
IL307671A 2021-04-15 2022-04-14 רשתות נויראליות עמוקות לניבוי פתוגניות של וריאנטים באמצעות מבני חלבון תלת מימדיים (3d) IL307671B2 (he)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US202163175495P 2021-04-15 2021-04-15
US17/232,056 US12217829B2 (en) 2021-04-15 2021-04-15 Artificial intelligence-based analysis of protein three-dimensional (3D) structures
US202163175767P 2021-04-16 2021-04-16
US17/468,411 US11515010B2 (en) 2021-04-15 2021-09-07 Deep convolutional neural networks to predict variant pathogenicity using three-dimensional (3D) protein structures
US17/703,935 US12444482B2 (en) 2021-04-15 2022-03-24 Multi-channel protein voxelization to predict variant pathogenicity using deep convolutional neural networks
US17/703,958 US20220336057A1 (en) 2021-04-15 2022-03-24 Efficient voxelization for deep learning
PCT/US2022/024913 WO2022221589A1 (en) 2021-04-15 2022-04-14 Deep convolutional neural networks to predict variant pathogenicity using three-dimensional (3d) protein structures

Publications (3)

Publication Number Publication Date
IL307671A IL307671A (he) 2023-12-01
IL307671B1 IL307671B1 (he) 2025-06-01
IL307671B2 true IL307671B2 (he) 2025-10-01

Family

ID=81580106

Family Applications (1)

Application Number Title Priority Date Filing Date
IL307671A IL307671B2 (he) 2021-04-15 2022-04-14 רשתות נויראליות עמוקות לניבוי פתוגניות של וריאנטים באמצעות מבני חלבון תלת מימדיים (3d)

Country Status (9)

Country Link
EP (1) EP4323990A1 (he)
JP (2) JP7712387B2 (he)
KR (1) KR20230171930A (he)
AU (1) AU2022256491A1 (he)
BR (1) BR112023021302A2 (he)
CA (1) CA3215462A1 (he)
IL (1) IL307671B2 (he)
MX (1) MX2023012228A (he)
WO (2) WO2022221589A1 (he)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116153435B (zh) * 2023-04-21 2023-08-11 山东大学齐鲁医院 基于上色与三维结构的多肽预测方法及系统

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9373059B1 (en) * 2014-05-05 2016-06-21 Atomwise Inc. Systems and methods for applying a convolutional network to spatial data
NZ759818A (en) * 2017-10-16 2022-04-29 Illumina Inc Semi-supervised learning for training an ensemble of deep convolutional neural networks
EP3704640A4 (en) * 2017-10-27 2021-08-18 Apostle, Inc. PREDICTING THE CANCER-RELATED PATHOGEN IMPACT OF SOMATIC MUTATIONS USING DEEP LEARNING-BASED PROCESSES
US11210554B2 (en) * 2019-03-21 2021-12-28 Illumina, Inc. Artificial intelligence-based generation of sequencing metadata
CN110245685B (zh) * 2019-05-15 2022-03-25 清华大学 基因组单位点变异致病性的预测方法、系统及存储介质
JP2024514894A (ja) * 2021-04-15 2024-04-03 イルミナ インコーポレイテッド 深層学習のための効率的なボクセル化
US12217829B2 (en) * 2021-04-15 2025-02-04 Illumina, Inc. Artificial intelligence-based analysis of protein three-dimensional (3D) structures

Also Published As

Publication number Publication date
JP7755105B2 (ja) 2025-10-15
BR112023021302A2 (pt) 2023-12-19
EP4323990A1 (en) 2024-02-21
WO2022221589A1 (en) 2022-10-20
JP7712387B2 (ja) 2025-07-23
CA3215462A1 (en) 2022-10-20
IL307671A (he) 2023-12-01
IL307671B1 (he) 2025-06-01
MX2023012228A (es) 2024-01-08
KR20230171930A (ko) 2023-12-21
JP2025148468A (ja) 2025-10-07
WO2022221587A1 (en) 2022-10-20
JP2024513994A (ja) 2024-03-27
AU2022256491A1 (en) 2023-10-26

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