IL305325B2 - שיטה ומערכת לדירוג הפרעה בהתפשטות תאים - Google Patents

שיטה ומערכת לדירוג הפרעה בהתפשטות תאים

Info

Publication number
IL305325B2
IL305325B2 IL305325A IL30532523A IL305325B2 IL 305325 B2 IL305325 B2 IL 305325B2 IL 305325 A IL305325 A IL 305325A IL 30532523 A IL30532523 A IL 30532523A IL 305325 B2 IL305325 B2 IL 305325B2
Authority
IL
Israel
Prior art keywords
cells
population
location
proliferation
value
Prior art date
Application number
IL305325A
Other languages
English (en)
Other versions
IL305325B1 (he
IL305325A (he
Original Assignee
Ariel Scient Innovations Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ariel Scient Innovations Ltd filed Critical Ariel Scient Innovations Ltd
Priority to IL305325A priority Critical patent/IL305325B2/he
Publication of IL305325A publication Critical patent/IL305325A/he
Priority to PCT/IL2024/050831 priority patent/WO2025041130A1/en
Publication of IL305325B1 publication Critical patent/IL305325B1/he
Publication of IL305325B2 publication Critical patent/IL305325B2/he

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0693—Tumour cells; Cancer cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
    • G01N21/3563—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing solids; Preparation of samples therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/55—Specular reflectivity
    • G01N21/552—Attenuated total reflection
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/575—
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/0002—Inspection of images, e.g. flaw detection
    • G06T7/0012—Biomedical image inspection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H10/00—ICT specially adapted for the handling or processing of patient-related medical or healthcare data
    • G16H10/40—ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H30/00—ICT specially adapted for the handling or processing of medical images
    • G16H30/20—ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H30/00—ICT specially adapted for the handling or processing of medical images
    • G16H30/40—ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/20—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/70—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2529/00—Culture process characterised by the use of electromagnetic stimulation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2529/00—Culture process characterised by the use of electromagnetic stimulation
    • C12N2529/10—Stimulation by light
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
    • G01N2021/3595—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using FTIR
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/10—Image acquisition modality
    • G06T2207/10048—Infrared image
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/20—Special algorithmic details
    • G06T2207/20081—Training; Learning
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing
    • G06T2207/30024—Cell structures in vitro; Tissue sections in vitro

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Medical Informatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Primary Health Care (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Data Mining & Analysis (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Databases & Information Systems (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Theoretical Computer Science (AREA)
IL305325A 2023-08-18 2023-08-18 שיטה ומערכת לדירוג הפרעה בהתפשטות תאים IL305325B2 (he)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IL305325A IL305325B2 (he) 2023-08-18 2023-08-18 שיטה ומערכת לדירוג הפרעה בהתפשטות תאים
PCT/IL2024/050831 WO2025041130A1 (en) 2023-08-18 2024-08-18 System and method for determining proliferative disorder levels

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL305325A IL305325B2 (he) 2023-08-18 2023-08-18 שיטה ומערכת לדירוג הפרעה בהתפשטות תאים

Publications (3)

Publication Number Publication Date
IL305325A IL305325A (he) 2023-09-01
IL305325B1 IL305325B1 (he) 2024-12-01
IL305325B2 true IL305325B2 (he) 2025-04-01

Family

ID=93742560

Family Applications (1)

Application Number Title Priority Date Filing Date
IL305325A IL305325B2 (he) 2023-08-18 2023-08-18 שיטה ומערכת לדירוג הפרעה בהתפשטות תאים

Country Status (2)

Country Link
IL (1) IL305325B2 (he)
WO (1) WO2025041130A1 (he)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5945674A (en) * 1997-07-30 1999-08-31 Vysis, Inc. Method of identifying cellular types in a biological sample supported on an absorptive substrate by infrared spectroscopy
US20190277755A1 (en) * 2016-07-05 2019-09-12 Pims- Passive Imaging Medical Systems Ltd Device and method for tissue diagnosis in real-time
EP3475705B1 (en) * 2016-06-24 2021-02-17 University of Strathclyde Analysis of bodily fluids using infrared spectroscopy for the diagnosis and/or prognosis of cancer
US20210239607A1 (en) * 2015-09-10 2021-08-05 Beamline Diagnostics Ltd Method, computer programme and system for analysing a sample comprising identifying or sorting cells according to the ftir spectrum each cell produces

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5945674A (en) * 1997-07-30 1999-08-31 Vysis, Inc. Method of identifying cellular types in a biological sample supported on an absorptive substrate by infrared spectroscopy
US20210239607A1 (en) * 2015-09-10 2021-08-05 Beamline Diagnostics Ltd Method, computer programme and system for analysing a sample comprising identifying or sorting cells according to the ftir spectrum each cell produces
EP3475705B1 (en) * 2016-06-24 2021-02-17 University of Strathclyde Analysis of bodily fluids using infrared spectroscopy for the diagnosis and/or prognosis of cancer
US20190277755A1 (en) * 2016-07-05 2019-09-12 Pims- Passive Imaging Medical Systems Ltd Device and method for tissue diagnosis in real-time

Also Published As

Publication number Publication date
IL305325B1 (he) 2024-12-01
IL305325A (he) 2023-09-01
WO2025041130A1 (en) 2025-02-27

Similar Documents

Publication Publication Date Title
US6385484B2 (en) Spectroscopic system employing a plurality of data types
US8885912B2 (en) Generate percentage of positive cells for biomarkers by normalizing and autothresholding the image intensity produced by immunohistochemistry technique
WO2021165771A1 (en) Noninvasive, multispectral-fluorescence characterization of biological tissues with machine/deep learning
JP2018502275A (ja) 分析の最適化および相関性の利用を含む、生体試料の分類方法および分類システム
Muldoon et al. Evaluation of quantitative image analysis criteria for the high-resolution microendoscopic detection of neoplasia in Barrett’s esophagus
US20110028808A1 (en) Method and apparatus for examination of cancer, systemic lupus erythematosus (sle), or antiphospholipid antibody syndrome using near-infrared light
WO2013030175A2 (en) Systems and methods for tissue classification
US20230113064A1 (en) Diagnostic system using diffraction analysis of in vitro samples
CN111528918B (zh) 消融术后肿瘤体积变化趋势图生成装置、设备及存储介质
Magalhães et al. Raman spectroscopy with a 1064-nm wavelength laser as a potential molecular tool for prostate cancer diagnosis: a pilot study
Halicek et al. Cancer detection using hyperspectral imaging and evaluation of the superficial tumor margin variance with depth
Mittal et al. A comparison of mid-infrared spectral regions on accuracy of tissue classification
Song et al. Weakly supervised AI for efficient analysis of 3D pathology samples
KR20220091408A (ko) 인공지능 라만 분석 기법을 이용한 췌장암 조기진단 방법
de Souza et al. Discrimination of molecular subtypes of breast cancer with ATR-FTIR spectroscopy in blood plasma coupled with partial least square-artificial neural network discriminant analysis (PLS-ANNDA)
CN116740431A (zh) 一种基于拉曼光谱的神经网络分类模型的构建方法及系统
Mahmoud et al. Multi-wavelength interference phase imaging for automatic breast cancer detection and delineation using diffuse reflection imaging
Zhang et al. Fiber optic probe‐based ATR‐FTIR spectroscopy for rapid breast cancer detection: A pilot study
IL305325B2 (he) שיטה ומערכת לדירוג הפרעה בהתפשטות תאים
Knighton et al. Toward cardiac tissue characterization using machine learning and light-scattering spectroscopy
del Real Mata et al. Evaluation of machine learning and deep learning models for the classification of a single extracellular vesicles spectral library
CN111220575A (zh) 一种基于太赫兹近场光谱的细胞检测方法
EP4643117A2 (en) Methods for diagnosing or monitoring a disease in a subject using spectroscopy
KR20250094135A (ko) 혈소판 분광분석 데이터를 이용한 암 진단을 위한 정보제공 방법
CN117530659A (zh) 基于光学相干层析成像技术的早期宫颈癌变辅助诊断工具