IL297925B2 - Baff-r targeted chimeric antigen receptor-modified t-cells and uses thereof - Google Patents

Baff-r targeted chimeric antigen receptor-modified t-cells and uses thereof

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Publication number
IL297925B2
IL297925B2 IL297925A IL29792522A IL297925B2 IL 297925 B2 IL297925 B2 IL 297925B2 IL 297925 A IL297925 A IL 297925A IL 29792522 A IL29792522 A IL 29792522A IL 297925 B2 IL297925 B2 IL 297925B2
Authority
IL
Israel
Prior art keywords
cells
baff
chain variable
optionally
variable region
Prior art date
Application number
IL297925A
Other languages
English (en)
Hebrew (he)
Other versions
IL297925A (en
IL297925B1 (en
Original Assignee
Univ Texas
Hope City
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Texas, Hope City filed Critical Univ Texas
Publication of IL297925A publication Critical patent/IL297925A/en
Publication of IL297925B1 publication Critical patent/IL297925B1/en
Publication of IL297925B2 publication Critical patent/IL297925B2/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/70517—CD8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C—CHEMISTRY; METALLURGY
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3061—Blood cells
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C—CHEMISTRY; METALLURGY
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    • C12N5/16—Animal cells
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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IL297925A 2016-06-06 2017-06-06 Baff-r targeted chimeric antigen receptor-modified t-cells and uses thereof IL297925B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662346324P 2016-06-06 2016-06-06
US201662396767P 2016-09-19 2016-09-19
PCT/US2017/036178 WO2017214167A1 (en) 2016-06-06 2017-06-06 Baff-r targeted chimeric antigen receptor-modified t-cells and uses thereof

Publications (3)

Publication Number Publication Date
IL297925A IL297925A (en) 2023-01-01
IL297925B1 IL297925B1 (en) 2024-05-01
IL297925B2 true IL297925B2 (en) 2024-09-01

Family

ID=59071115

Family Applications (4)

Application Number Title Priority Date Filing Date
IL263385A IL263385B2 (en) 2016-06-06 2017-06-06 Modified t cells - Baff-r targeted chimeric antigen receptor
IL311985A IL311985A (en) 2016-06-06 2017-06-06 Baff-r targeted chimeric antigen receptor-modified t-cells and uses thereof
IL297925A IL297925B2 (en) 2016-06-06 2017-06-06 Baff-r targeted chimeric antigen receptor-modified t-cells and uses thereof
IL308798A IL308798A (en) 2016-06-06 2017-06-06 Baff-r targeted chimeric antigen receptor-modified t-cells and uses thereof

Family Applications Before (2)

Application Number Title Priority Date Filing Date
IL263385A IL263385B2 (en) 2016-06-06 2017-06-06 Modified t cells - Baff-r targeted chimeric antigen receptor
IL311985A IL311985A (en) 2016-06-06 2017-06-06 Baff-r targeted chimeric antigen receptor-modified t-cells and uses thereof

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Application Number Title Priority Date Filing Date
IL308798A IL308798A (en) 2016-06-06 2017-06-06 Baff-r targeted chimeric antigen receptor-modified t-cells and uses thereof

Country Status (10)

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US (3) US11161908B2 (OSRAM)
EP (1) EP3464371A1 (OSRAM)
JP (1) JP7070932B2 (OSRAM)
KR (6) KR20250084978A (OSRAM)
CN (2) CN115960251A (OSRAM)
AU (2) AU2017277269C1 (OSRAM)
CA (1) CA3026640A1 (OSRAM)
IL (4) IL263385B2 (OSRAM)
SG (1) SG11201810887UA (OSRAM)
WO (1) WO2017214167A1 (OSRAM)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
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EP2934532B1 (en) 2012-12-20 2019-10-23 Purdue Research Foundation Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics
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