IL294094A - conjunctions - Google Patents
conjunctionsInfo
- Publication number
- IL294094A IL294094A IL294094A IL29409422A IL294094A IL 294094 A IL294094 A IL 294094A IL 294094 A IL294094 A IL 294094A IL 29409422 A IL29409422 A IL 29409422A IL 294094 A IL294094 A IL 294094A
- Authority
- IL
- Israel
- Prior art keywords
- unsubstituted
- substituted
- cancer
- alkyl
- group
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 claims description 168
- 150000003839 salts Chemical class 0.000 claims description 81
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 39
- 206010028980 Neoplasm Diseases 0.000 claims description 37
- 229910052736 halogen Inorganic materials 0.000 claims description 36
- 150000002367 halogens Chemical group 0.000 claims description 36
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 35
- 201000010099 disease Diseases 0.000 claims description 34
- 229910052739 hydrogen Inorganic materials 0.000 claims description 32
- 239000001257 hydrogen Substances 0.000 claims description 32
- 150000001412 amines Chemical class 0.000 claims description 26
- 150000002431 hydrogen Chemical group 0.000 claims description 23
- 125000002950 monocyclic group Chemical group 0.000 claims description 21
- 201000011510 cancer Diseases 0.000 claims description 18
- 125000004452 carbocyclyl group Chemical group 0.000 claims description 18
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 13
- 125000002252 acyl group Chemical group 0.000 claims description 12
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 11
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 10
- 125000002618 bicyclic heterocycle group Chemical group 0.000 claims description 8
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 8
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 8
- 239000012664 BCL-2-inhibitor Substances 0.000 claims description 7
- 229940123711 Bcl2 inhibitor Drugs 0.000 claims description 7
- 125000000041 C6-C10 aryl group Chemical group 0.000 claims description 7
- 208000002250 Hematologic Neoplasms Diseases 0.000 claims description 7
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- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims description 5
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims description 5
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims description 5
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- 125000000000 cycloalkoxy group Chemical group 0.000 claims description 4
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- 208000000649 small cell carcinoma Diseases 0.000 claims description 4
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- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims description 3
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- 206010033128 Ovarian cancer Diseases 0.000 claims description 2
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- 208000002471 Penile Neoplasms Diseases 0.000 claims description 2
- 206010034299 Penile cancer Diseases 0.000 claims description 2
- 206010060862 Prostate cancer Diseases 0.000 claims description 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 2
- 208000015634 Rectal Neoplasms Diseases 0.000 claims description 2
- 206010039491 Sarcoma Diseases 0.000 claims description 2
- 208000000453 Skin Neoplasms Diseases 0.000 claims description 2
- 208000021712 Soft tissue sarcoma Diseases 0.000 claims description 2
- 208000024770 Thyroid neoplasm Diseases 0.000 claims description 2
- 208000023915 Ureteral Neoplasms Diseases 0.000 claims description 2
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- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims description 2
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims description 2
- 208000026900 bile duct neoplasm Diseases 0.000 claims description 2
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- 210000000232 gallbladder Anatomy 0.000 claims description 2
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- 208000014829 head and neck neoplasm Diseases 0.000 claims description 2
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- 201000002510 thyroid cancer Diseases 0.000 claims description 2
- 201000011294 ureter cancer Diseases 0.000 claims description 2
- 201000005112 urinary bladder cancer Diseases 0.000 claims description 2
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- LQBVNQSMGBZMKD-UHFFFAOYSA-N venetoclax Chemical compound C=1C=C(Cl)C=CC=1C=1CC(C)(C)CCC=1CN(CC1)CCN1C(C=C1OC=2C=C3C=CNC3=NC=2)=CC=C1C(=O)NS(=O)(=O)C(C=C1[N+]([O-])=O)=CC=C1NCC1CCOCC1 LQBVNQSMGBZMKD-UHFFFAOYSA-N 0.000 claims 2
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- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 1
- 206010061424 Anal cancer Diseases 0.000 claims 1
- 208000007860 Anus Neoplasms Diseases 0.000 claims 1
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- VYXJULKGMXJVGI-XIFFEERXSA-N n-(4-hydroxyphenyl)-3-[6-[(3s)-3-(morpholin-4-ylmethyl)-3,4-dihydro-1h-isoquinoline-2-carbonyl]-1,3-benzodioxol-5-yl]-n-phenyl-5,6,7,8-tetrahydroindolizine-1-carboxamide Chemical compound C1=CC(O)=CC=C1N(C=1C=CC=CC=1)C(=O)C1=C2CCCCN2C(C=2C(=CC=3OCOC=3C=2)C(=O)N2[C@@H](CC3=CC=CC=C3C2)CN2CCOCC2)=C1 VYXJULKGMXJVGI-XIFFEERXSA-N 0.000 claims 1
- JLYAXFNOILIKPP-KXQOOQHDSA-N navitoclax Chemical compound C([C@@H](NC1=CC=C(C=C1S(=O)(=O)C(F)(F)F)S(=O)(=O)NC(=O)C1=CC=C(C=C1)N1CCN(CC1)CC1=C(CCC(C1)(C)C)C=1C=CC(Cl)=CC=1)CSC=1C=CC=CC=1)CN1CCOCC1 JLYAXFNOILIKPP-KXQOOQHDSA-N 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 description 101
- 125000003118 aryl group Chemical group 0.000 description 48
- 125000000623 heterocyclic group Chemical group 0.000 description 47
- 125000001072 heteroaryl group Chemical group 0.000 description 42
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- 125000005842 heteroatom Chemical group 0.000 description 26
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 25
- 125000001424 substituent group Chemical group 0.000 description 22
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- 150000003254 radicals Chemical class 0.000 description 9
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- 230000001988 toxicity Effects 0.000 description 7
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Steroid Compounds (AREA)
- Glass Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962952032P | 2019-12-20 | 2019-12-20 | |
| PCT/US2020/065410 WO2021127045A1 (fr) | 2019-12-20 | 2020-12-16 | Associations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL294094A true IL294094A (en) | 2022-08-01 |
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| IL294094A IL294094A (en) | 2019-12-20 | 2020-12-16 | conjunctions |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20230054854A1 (fr) |
| EP (1) | EP4069242A4 (fr) |
| JP (1) | JP2023508332A (fr) |
| KR (1) | KR20220119420A (fr) |
| CN (1) | CN115135325A (fr) |
| AU (1) | AU2020404996A1 (fr) |
| BR (1) | BR112022012283A2 (fr) |
| CA (1) | CA3165474A1 (fr) |
| IL (1) | IL294094A (fr) |
| MX (1) | MX2022007623A (fr) |
| TW (1) | TW202135819A (fr) |
| WO (1) | WO2021127045A1 (fr) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CA3089746A1 (fr) | 2018-03-09 | 2019-09-12 | Recurium Ip Holdings, Llc | L,2-dihydro-3h-pyrazolo[3,4-d]pyrimidin-3-ones substituees |
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| MX2020007392A (es) * | 2018-01-10 | 2020-10-14 | Recurium Ip Holdings Llc | Compuestos de benzamida. |
| US11479555B2 (en) * | 2018-02-23 | 2022-10-25 | Newave Pharmaceutical Inc. | Substituted 1,2-dihydro-3H-pyrazolo[3,4-D]pyrimidin-3-ones as inhibitors of WEE-1 kinase |
| US20200405723A1 (en) * | 2018-02-28 | 2020-12-31 | The Regents Of The University Of Colorado, A Body Corporate | Wee1 kinase inhibitors and methods of treating cancer using the same |
| CA3089746A1 (fr) * | 2018-03-09 | 2019-09-12 | Recurium Ip Holdings, Llc | L,2-dihydro-3h-pyrazolo[3,4-d]pyrimidin-3-ones substituees |
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2020
- 2020-12-16 CN CN202080095323.7A patent/CN115135325A/zh active Pending
- 2020-12-16 MX MX2022007623A patent/MX2022007623A/es unknown
- 2020-12-16 AU AU2020404996A patent/AU2020404996A1/en active Pending
- 2020-12-16 WO PCT/US2020/065410 patent/WO2021127045A1/fr unknown
- 2020-12-16 EP EP20904098.9A patent/EP4069242A4/fr active Pending
- 2020-12-16 US US17/757,530 patent/US20230054854A1/en active Pending
- 2020-12-16 CA CA3165474A patent/CA3165474A1/fr active Pending
- 2020-12-16 JP JP2022538232A patent/JP2023508332A/ja active Pending
- 2020-12-16 IL IL294094A patent/IL294094A/en unknown
- 2020-12-16 KR KR1020227024701A patent/KR20220119420A/ko unknown
- 2020-12-16 BR BR112022012283A patent/BR112022012283A2/pt unknown
- 2020-12-18 TW TW109145167A patent/TW202135819A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2023508332A (ja) | 2023-03-02 |
| CA3165474A1 (fr) | 2021-06-24 |
| MX2022007623A (es) | 2022-09-23 |
| WO2021127045A1 (fr) | 2021-06-24 |
| TW202135819A (zh) | 2021-10-01 |
| CN115135325A (zh) | 2022-09-30 |
| BR112022012283A2 (pt) | 2022-08-30 |
| AU2020404996A1 (en) | 2022-07-14 |
| EP4069242A1 (fr) | 2022-10-12 |
| KR20220119420A (ko) | 2022-08-29 |
| EP4069242A4 (fr) | 2024-01-10 |
| US20230054854A1 (en) | 2023-02-23 |
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