IL281770A - Indane derivatives for use in the treatment of bacterial infection - Google Patents
Indane derivatives for use in the treatment of bacterial infectionInfo
- Publication number
- IL281770A IL281770A IL281770A IL28177021A IL281770A IL 281770 A IL281770 A IL 281770A IL 281770 A IL281770 A IL 281770A IL 28177021 A IL28177021 A IL 28177021A IL 281770 A IL281770 A IL 281770A
- Authority
- IL
- Israel
- Prior art keywords
- treatment
- bacterial infection
- indane derivatives
- indane
- derivatives
- Prior art date
Links
- 208000035143 Bacterial infection Diseases 0.000 title 1
- 208000022362 bacterial infectious disease Diseases 0.000 title 1
- 125000003392 indanyl group Chemical class C1(CCC2=CC=CC=C12)* 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
- A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18290106.6A EP3628666A1 (en) | 2018-09-25 | 2018-09-25 | Indane derivatives for use in the treatment of bacterial infection |
| EP18290104 | 2018-09-26 | ||
| EP18197365 | 2018-09-27 | ||
| PCT/EP2019/070115 WO2020064173A1 (en) | 2018-09-25 | 2019-07-25 | Indane derivatives for use in the treatment of bacterial infection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL281770A true IL281770A (en) | 2021-05-31 |
Family
ID=67439236
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL281770A IL281770A (en) | 2018-09-25 | 2021-03-24 | Indane derivatives for use in the treatment of bacterial infection |
| IL281780A IL281780A (en) | 2018-09-25 | 2021-03-24 | Indane derivatives for use in the treatment of bacterial infection |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL281780A IL281780A (en) | 2018-09-25 | 2021-03-24 | Indane derivatives for use in the treatment of bacterial infection |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20220112169A1 (en) |
| EP (2) | EP3856729A1 (en) |
| JP (2) | JP7429993B2 (en) |
| KR (2) | KR20210087025A (en) |
| CN (2) | CN113166085B (en) |
| AU (2) | AU2019351551A1 (en) |
| BR (2) | BR112021005651A2 (en) |
| CA (2) | CA3113689A1 (en) |
| CL (2) | CL2021000731A1 (en) |
| IL (2) | IL281770A (en) |
| MA (2) | MA53707A (en) |
| MX (2) | MX2021003498A (en) |
| SG (2) | SG11202102790PA (en) |
| WO (2) | WO2020064174A1 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020064174A1 (en) * | 2018-09-25 | 2020-04-02 | Antabio Sas | Indane derivatives for use in the treatment of bacterial infection |
| US20240016941A1 (en) * | 2020-03-24 | 2024-01-18 | Antabio Sas | Combination therapy |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5457196A (en) * | 1991-09-27 | 1995-10-10 | Merrell Dow Pharmaceuticals Inc. | 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE |
| JP3126541B2 (en) * | 1993-03-26 | 2001-01-22 | 千寿製薬株式会社 | Benzothiazole derivatives, their preparation and their use |
| JPH0782259A (en) * | 1993-09-14 | 1995-03-28 | Senju Pharmaceut Co Ltd | Succinamic acid derivative and medicine containing the same for therapy of diabetic complications |
| JPH11130761A (en) * | 1997-10-24 | 1999-05-18 | Otsuka Pharmaceut Co Ltd | Benzothiazole derivative |
| CA2579221A1 (en) | 2004-09-08 | 2006-03-16 | Merck & Co., Inc. | Monocyclic anilide spirolactam cgrp receptor antagonists |
| FR2883876B1 (en) | 2005-03-30 | 2007-05-04 | Servier Lab | INDANYL-PIPERAZINE DERIVATIVES, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME |
| US7674507B2 (en) | 2005-05-25 | 2010-03-09 | Merck Patent Gmbh | Pyran-dioxane derivatives, and the use thereof in liquid-crystalline media |
| MY154462A (en) | 2007-06-05 | 2015-06-30 | Sanofi Aventis | Substituted benzoylamino-indan-2-carboxylic acids and related compounds |
| EP2141164A1 (en) | 2008-07-01 | 2010-01-06 | Mutabilis | New 1,2,4-triazine derivatives and biological applications thereof |
| US8877815B2 (en) | 2010-11-16 | 2014-11-04 | Novartis Ag | Substituted carbamoylcycloalkyl acetic acid derivatives as NEP |
| US9775349B2 (en) * | 2012-11-30 | 2017-10-03 | Bayer Cropscience Ag | Binary fungicidal or pesticidal mixture |
| GB201704476D0 (en) * | 2017-03-21 | 2017-05-03 | Antabio Sas | Chemical compounds |
| WO2020064174A1 (en) * | 2018-09-25 | 2020-04-02 | Antabio Sas | Indane derivatives for use in the treatment of bacterial infection |
-
2019
- 2019-07-25 WO PCT/EP2019/070116 patent/WO2020064174A1/en unknown
- 2019-07-25 EP EP19744709.7A patent/EP3856729A1/en active Pending
- 2019-07-25 MX MX2021003498A patent/MX2021003498A/en unknown
- 2019-07-25 US US17/277,535 patent/US20220112169A1/en active Pending
- 2019-07-25 CA CA3113689A patent/CA3113689A1/en active Pending
- 2019-07-25 CA CA3113697A patent/CA3113697A1/en active Pending
- 2019-07-25 CN CN201980066561.2A patent/CN113166085B/en active Active
- 2019-07-25 WO PCT/EP2019/070115 patent/WO2020064173A1/en unknown
- 2019-07-25 BR BR112021005651-3A patent/BR112021005651A2/en unknown
- 2019-07-25 MA MA053707A patent/MA53707A/en unknown
- 2019-07-25 MA MA053706A patent/MA53706A/en unknown
- 2019-07-25 AU AU2019351551A patent/AU2019351551A1/en active Pending
- 2019-07-25 KR KR1020217012349A patent/KR20210087025A/en not_active Application Discontinuation
- 2019-07-25 CN CN201980063308.1A patent/CN113166084B/en active Active
- 2019-07-25 BR BR112021005532-0A patent/BR112021005532A2/en unknown
- 2019-07-25 JP JP2021540370A patent/JP7429993B2/en active Active
- 2019-07-25 EP EP19744710.5A patent/EP3856730A1/en active Pending
- 2019-07-25 SG SG11202102790PA patent/SG11202102790PA/en unknown
- 2019-07-25 SG SG11202102791SA patent/SG11202102791SA/en unknown
- 2019-07-25 MX MX2021003485A patent/MX2021003485A/en unknown
- 2019-07-25 US US17/277,649 patent/US20210347748A1/en active Pending
- 2019-07-25 JP JP2021540369A patent/JP7429992B2/en active Active
- 2019-07-25 KR KR1020217012348A patent/KR20210087448A/en not_active Application Discontinuation
- 2019-07-25 AU AU2019349438A patent/AU2019349438A1/en active Pending
-
2021
- 2021-03-24 CL CL2021000731A patent/CL2021000731A1/en unknown
- 2021-03-24 CL CL2021000729A patent/CL2021000729A1/en unknown
- 2021-03-24 IL IL281770A patent/IL281770A/en unknown
- 2021-03-24 IL IL281780A patent/IL281780A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20220112169A1 (en) | 2022-04-14 |
| SG11202102791SA (en) | 2021-04-29 |
| CN113166085B (en) | 2024-04-09 |
| MX2021003498A (en) | 2021-09-10 |
| MA53706A (en) | 2021-12-29 |
| BR112021005532A2 (en) | 2021-06-29 |
| CN113166084B (en) | 2024-06-04 |
| KR20210087025A (en) | 2021-07-09 |
| SG11202102790PA (en) | 2021-04-29 |
| CL2021000729A1 (en) | 2021-11-05 |
| KR20210087448A (en) | 2021-07-12 |
| WO2020064174A1 (en) | 2020-04-02 |
| IL281780A (en) | 2021-05-31 |
| US20210347748A1 (en) | 2021-11-11 |
| CA3113689A1 (en) | 2020-04-02 |
| EP3856730A1 (en) | 2021-08-04 |
| JP2022502486A (en) | 2022-01-11 |
| AU2019351551A1 (en) | 2021-04-15 |
| CN113166084A (en) | 2021-07-23 |
| CL2021000731A1 (en) | 2021-11-05 |
| MX2021003485A (en) | 2021-09-10 |
| JP7429992B2 (en) | 2024-02-09 |
| JP2022502485A (en) | 2022-01-11 |
| JP7429993B2 (en) | 2024-02-09 |
| BR112021005651A2 (en) | 2021-06-22 |
| WO2020064173A1 (en) | 2020-04-02 |
| MA53707A (en) | 2021-12-29 |
| EP3856729A1 (en) | 2021-08-04 |
| CA3113697A1 (en) | 2020-04-02 |
| AU2019349438A1 (en) | 2021-04-15 |
| CN113166085A (en) | 2021-07-23 |
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