IL273684A - וריאנטים של beta–glucocerebrosidase לטיפול במחלת גושה - Google Patents

וריאנטים של beta–glucocerebrosidase לטיפול במחלת גושה

Info

Publication number
IL273684A
IL273684A IL273684A IL27368420A IL273684A IL 273684 A IL273684 A IL 273684A IL 273684 A IL273684 A IL 273684A IL 27368420 A IL27368420 A IL 27368420A IL 273684 A IL273684 A IL 273684A
Authority
IL
Israel
Prior art keywords
glucocerebrosidase
variants
beta
gaucher disease
treating gaucher
Prior art date
Application number
IL273684A
Other languages
English (en)
Inventor
Silman Israel
Ashani Yaacov
L Sussman Joel
Khersonsky Olga
FLEISHMAN Sarel
Goldenzweig Adi
H Futerman Anthony
POKORNA Sarka
Original Assignee
Yeda Res & Dev
Silman Israel
Ashani Yaacov
L Sussman Joel
Khersonsky Olga
FLEISHMAN Sarel
Goldenzweig Adi
H Futerman Anthony
POKORNA Sarka
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Res & Dev, Silman Israel, Ashani Yaacov, L Sussman Joel, Khersonsky Olga, FLEISHMAN Sarel, Goldenzweig Adi, H Futerman Anthony, POKORNA Sarka filed Critical Yeda Res & Dev
Priority to IL273684A priority Critical patent/IL273684A/he
Priority to IL296696A priority patent/IL296696A/he
Priority to US17/915,500 priority patent/US20230132790A1/en
Priority to EP21720584.8A priority patent/EP4126226A1/en
Priority to CA3174917A priority patent/CA3174917A1/en
Priority to CN202180026117.5A priority patent/CN115348884B/zh
Priority to JP2022559375A priority patent/JP7830343B2/ja
Priority to KR1020227037779A priority patent/KR20230003492A/ko
Priority to BR112022019510A priority patent/BR112022019510A2/pt
Priority to PCT/IL2021/050357 priority patent/WO2021199039A1/en
Priority to AU2021245409A priority patent/AU2021245409B2/en
Publication of IL273684A publication Critical patent/IL273684A/he

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Diabetes (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
IL273684A 2020-03-29 2020-03-29 וריאנטים של beta–glucocerebrosidase לטיפול במחלת גושה IL273684A (he)

Priority Applications (11)

Application Number Priority Date Filing Date Title
IL273684A IL273684A (he) 2020-03-29 2020-03-29 וריאנטים של beta–glucocerebrosidase לטיפול במחלת גושה
IL296696A IL296696A (he) 2020-03-29 2021-03-29 וריאנטים של beta-glucocerebrosidase לטיפול במחלת גושה
US17/915,500 US20230132790A1 (en) 2020-03-29 2021-03-29 Variants of beta-glucocerebrosidase for use in treating gaucher disease
EP21720584.8A EP4126226A1 (en) 2020-03-29 2021-03-29 Variants of beta-glucocerebrosidase for use in treating gaucher disease
CA3174917A CA3174917A1 (en) 2020-03-29 2021-03-29 Variants of beta-glucocerebrosidase for use in treating gaucher disease
CN202180026117.5A CN115348884B (zh) 2020-03-29 2021-03-29 用于治疗戈谢病的β-葡糖脑苷脂酶变体
JP2022559375A JP7830343B2 (ja) 2020-03-29 2021-03-29 ゴーシェ病の処置において使用するためのベータ－グルコセレブロシダーゼのバリアント
KR1020227037779A KR20230003492A (ko) 2020-03-29 2021-03-29 고셔병 치료용 베타-글루코세레브로시다아제 변이체
BR112022019510A BR112022019510A2 (pt) 2020-03-29 2021-03-29 Variantes de beta-glucocerebrosidase para uso no tratamento de doença de gaucher
PCT/IL2021/050357 WO2021199039A1 (en) 2020-03-29 2021-03-29 Variants of beta-glucocerebrosidase for use in treating gaucher disease
AU2021245409A AU2021245409B2 (en) 2020-03-29 2021-03-29 Variants of beta-glucocerebrosidase for use in treating Gaucher Disease

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL273684A IL273684A (he) 2020-03-29 2020-03-29 וריאנטים של beta–glucocerebrosidase לטיפול במחלת גושה

Publications (1)

Publication Number Publication Date
IL273684A true IL273684A (he) 2021-09-30

Family

ID=77989484

Family Applications (1)

Application Number Title Priority Date Filing Date
IL273684A IL273684A (he) 2020-03-29 2020-03-29 וריאנטים של beta–glucocerebrosidase לטיפול במחלת גושה

Country Status (1)

Country Link
IL (1) IL273684A (he)

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