IL268917B - A population-based immunogenic peptide identification platform - Google Patents

A population-based immunogenic peptide identification platform

Info

Publication number
IL268917B
IL268917B IL268917A IL26891719A IL268917B IL 268917 B IL268917 B IL 268917B IL 268917 A IL268917 A IL 268917A IL 26891719 A IL26891719 A IL 26891719A IL 268917 B IL268917 B IL 268917B
Authority
IL
Israel
Prior art keywords
population
immunogenic peptide
identification platform
peptide identification
based immunogenic
Prior art date
Application number
IL268917A
Other languages
Hebrew (he)
Other versions
IL268917A (en
IL268917B2 (en
Original Assignee
Treos Bio Zrt
Treos Bio Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=61386864&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL268917(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from EP17159243.9A external-priority patent/EP3370065A1/en
Priority claimed from EP17159242.1A external-priority patent/EP3369431A1/en
Priority claimed from GBGB1703809.2A external-priority patent/GB201703809D0/en
Application filed by Treos Bio Zrt, Treos Bio Ltd filed Critical Treos Bio Zrt
Publication of IL268917A publication Critical patent/IL268917A/en
Publication of IL268917B publication Critical patent/IL268917B/en
Publication of IL268917B2 publication Critical patent/IL268917B2/en

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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
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Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2980039A1 (en) * 2015-03-20 2016-09-29 Children's National Medical Center Generating virus or other antigen-specific t cells from a naive t cell population
JP7751374B2 (en) 2017-03-03 2025-10-08 トレオス バイオ リミテッド peptide vaccine
AU2019334437A1 (en) 2018-09-04 2021-03-18 Treos Bio Limited Peptide vaccines
GB201814361D0 (en) * 2018-09-04 2018-10-17 Treos Bio Zrt Immunogenetic cancer screening test
GB201814362D0 (en) * 2018-09-04 2018-10-17 Treos Bio Zrt Composition and process for preparing vaccine
TW202028224A (en) * 2018-09-17 2020-08-01 德商英麥提克生物技術股份有限公司 B*44 restricted peptides for use in immunotherapy against cancers and related methods
US12331320B2 (en) 2018-10-10 2025-06-17 The Research Foundation For The State University Of New York Genome edited cancer cell vaccines
TW202039535A (en) 2018-12-18 2020-11-01 德商英麥提克生物技術股份有限公司 Immunotherapy with b*08 restricted peptides and combination of peptides against cancers and related methods
US20230087422A1 (en) * 2020-02-07 2023-03-23 Isa Pharmaceuticals B.V. Treatment of hpv-related diseases
KR102159921B1 (en) * 2020-03-24 2020-09-25 주식회사 테라젠바이오 Method for predicting neoantigen using a peptide sequence and hla allele sequence and computer program
CN115715199A (en) 2020-04-03 2023-02-24 帕普泰克疫苗有限公司 Coronavirus vaccine
GB202004974D0 (en) 2020-04-03 2020-05-20 Treos Bio Ltd Coronavirus vaccine
CN115104156A (en) * 2020-04-20 2022-09-23 Nec实验室欧洲有限公司 Methods and systems for optimizing vaccine design
CN112048001B (en) * 2020-09-08 2022-04-05 南方科技大学 A kind of tumor neoantigen polypeptide and its application
KR102278727B1 (en) * 2020-09-16 2021-07-19 주식회사 테라젠바이오 Method for predicting neoantigen using a peptide sequence and hla class ii allele sequence and computer program
US20250022552A1 (en) 2021-08-10 2025-01-16 Nec Corporation Information processing system and information processing method
TWI898159B (en) 2021-10-04 2025-09-21 日商日本電氣股份有限公司 Management methods, management systems and electronic health record systems
WO2023059606A1 (en) * 2021-10-06 2023-04-13 Cancervax, Inc. Methods and compositions for cancer treatment
US20250297036A1 (en) * 2022-04-27 2025-09-25 POSTECH Research and Business Development Foundation Method for constructing hotspot-derived peptide-nucleic acid hybrid molecules on basis of in vitro selection
CN115785203B (en) * 2022-06-10 2024-03-12 河北博海生物工程开发有限公司 Lung cancer specific molecular target 10 and application thereof
EP4575867A4 (en) 2022-08-17 2025-10-01 Nec Corp INFORMATION PROCESSING SYSTEM, INFORMATION PROCESSING METHOD AND PROGRAM
GB202216453D0 (en) 2022-11-04 2022-12-21 Lisziewicz Julianna Identification of antigens which induce t-cell responses

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2042600A1 (en) * 2007-09-28 2009-04-01 Commissariat A L'energie Atomique A public and immunogenic CD4+ T Cell epitope of the hiv tat protein and its applications
US20100074925A1 (en) * 2006-09-21 2010-03-25 Vaxil Biotherapeutics Ltd Antigen specific multi epitope vaccines
EP2745845A1 (en) * 2012-12-19 2014-06-25 Centre Hospitalier Universitaire de Bordeaux A method for preventing or treating an HIV infection
WO2015164798A1 (en) * 2014-04-25 2015-10-29 Tria Bioscience Corp. Synthetic hapten carrier compositions and methods

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235877A (en) 1979-06-27 1980-11-25 Merck & Co., Inc. Liposome particle containing viral or bacterial antigenic subunit
EP0914142B9 (en) 1996-03-11 2012-01-04 Epimmune Inc. Peptides with increased binding affinity for at least three hla-a3-like molecules
US6617434B1 (en) * 1996-05-31 2003-09-09 North Shore Long Island Jewish Research Institute Identificiaton of differentially methylated and mutated nucleic acids
US20030148463A1 (en) 1997-04-14 2003-08-07 Micromet Ag Novel method for the production of anti-human antigen receptors and uses thereof
CN100387621C (en) * 1997-04-14 2008-05-14 麦可麦脱股份公司 Production method and use of anti-human antigen receptor
FR2791895B1 (en) 1999-03-23 2001-06-15 Pasteur Merieux Serums Vacc USE OF TREHALOSE TO STABILIZE A LIQUID VACCINE
AUPQ776100A0 (en) 2000-05-26 2000-06-15 Australian National University, The Synthetic molecules and uses therefor
US6673580B2 (en) 2000-10-27 2004-01-06 Genentech, Inc. Identification and modification of immunodominant epitopes in polypeptides
US7892559B2 (en) 2002-01-30 2011-02-22 Survac Aps Survivin-derived peptides and use thereof
CN1691964A (en) 2002-09-06 2005-11-02 曼康公司 epitope sequence
GB0228900D0 (en) 2002-12-11 2003-01-15 Ml Lab Plc Cancer Immunotherapy
CA2522379C (en) 2003-04-10 2012-10-23 Chiron Corporation The severe acute respiratory syndrome coronavirus
US20050084913A1 (en) * 2003-04-22 2005-04-21 Maxygen, Inc. Novel tumor-associated antigens
US20050100883A1 (en) 2003-11-12 2005-05-12 Wang Chang Y. Peptide-based diagnostic reagents for SARS
CN101434647A (en) 2004-01-20 2009-05-20 爱知县 Epitope/peptide recognized by hla-a2402-restricted ep/cam-specific ctl and use of the same
AU2005250170A1 (en) 2004-06-01 2005-12-15 Genimmune N.V. Peptides for inducing a CTL and/or HTL response to hepatitis C virus
EP1842911A4 (en) 2005-01-25 2008-12-10 Nec Corp HLA-BINDING PEPTIDES, DNA FRAGMENTS ENCODING SUCH PEPTIDES AND RECOMBINANT VECTORS
ES2523172T3 (en) 2005-02-04 2014-11-21 Survac Aps Survivin Peptide Vaccine
CN100402554C (en) * 2005-02-25 2008-07-16 李玉新 Preparation and application of testis-specific protein 50 human antibody
FR2891462B1 (en) 2005-09-30 2009-10-16 Commissariat Energie Atomique CD4 + EPITOPES OF SURVIVIN AND THEIR APPLICATIONS
GB0520067D0 (en) 2005-10-01 2005-11-09 Cancer Rec Tech Ltd Treatment of cancer
CA2700573C (en) 2006-09-26 2016-11-22 Cedars-Sinai Medical Center Cancer stem cell antigen vaccines and methods
EP2361930A3 (en) 2007-03-26 2011-10-26 Dako Denmark A/S Multimers of MHC-peptide complexes and uses thereof in Borrelia infectious diseases
WO2009123188A1 (en) 2008-03-31 2009-10-08 株式会社バイオイミュランス Partial peptide of survivin presented on mhc class ii molecule and use thereof
NO2119726T3 (en) 2008-05-14 2015-05-23
TW201008574A (en) 2008-08-19 2010-03-01 Oncotherapy Science Inc INHBB epitope peptides and vaccines containing the same
EP2337795A2 (en) 2008-10-01 2011-06-29 Dako Denmark A/S Mhc multimers in cancer vaccines and immune monitoring
GB0818065D0 (en) * 2008-10-02 2008-11-05 Cancer Rec Tech Ltd Immunogenic peptides and uses thereof
US20120244145A1 (en) * 2009-11-16 2012-09-27 Duke University Enhanced immunological responses
GB201004575D0 (en) * 2010-03-19 2010-05-05 Immatics Biotechnologies Gmbh Composition of tumor associated peptides and related anti cancer vaccine for the treatment of gastric cancer and other cancers
US20170039314A1 (en) * 2010-03-23 2017-02-09 Iogenetics, Llc Bioinformatic processes for determination of peptide binding
WO2012051282A2 (en) * 2010-10-14 2012-04-19 The Ohio State University Research Foundation Piwil2-like (pl2l) proteins-targeted cancer diagnosis and therapy
SI2945647T1 (en) * 2013-01-15 2021-01-29 Memorial Sloan Kettering Cancer Center Immunogenic wt-1 peptides and methods of use thereof
WO2014180490A1 (en) 2013-05-10 2014-11-13 Biontech Ag Predicting immunogenicity of t cell epitopes
GB201315946D0 (en) 2013-09-06 2013-10-23 Immune Targeting Systems Its Ltd Oncology vaccine
EA201690912A1 (en) * 2013-11-05 2016-10-31 Когнейт Биосервисис, Инк. COMBINATION INHIBITORS OF CONTROL POINTS AND THERAPEUTIC REMEDIES FOR THE TREATMENT OF CANCER
US9884895B2 (en) 2014-03-20 2018-02-06 The University Of North Carolina At Chapel Hill Methods and compositions for chimeric coronavirus spike proteins
WO2016040900A1 (en) 2014-09-14 2016-03-17 Washington University Personalized cancer vaccines and methods therefor
CA2969231C (en) * 2014-12-03 2021-06-08 Verik Bio, Inc. Identification, selection and use of high curative potential t cell epitopes
TW201636358A (en) * 2014-12-09 2016-10-16 腫瘤療法 科學股份有限公司 GPC3 epitope peptide of TH1 cells and vaccine containing the same
WO2016172722A1 (en) 2015-04-23 2016-10-27 Nantomics, Llc Cancer neoepitopes
US11090332B2 (en) 2015-05-21 2021-08-17 Regen BioPharma, Inc. Antigen specific mRNA cellular cancer vaccines
CA3003251A1 (en) 2015-10-12 2017-04-20 Nantomics, Llc Systems, compositions, and methods for discovery of msi and neoepitopes that predict sensitivity to checkpoint inhibitors
GB201604755D0 (en) 2016-03-21 2016-05-04 Vaxeal Res Sas Immunogenic compositions
CN110352067B (en) 2016-10-07 2024-09-24 得克萨斯州大学系统董事会 HLA-restricted VGLL1 peptides and uses thereof
TWI796314B (en) 2017-01-27 2023-03-21 德商英麥提克生物技術股份有限公司 Novel peptides and combination of peptides for use in immunotherapy against ovarian cancer and other cancers
JP7751374B2 (en) 2017-03-03 2025-10-08 トレオス バイオ リミテッド peptide vaccine
EP3369431A1 (en) 2017-03-03 2018-09-05 Treos Bio Kft Vaccine
EP3370065A1 (en) 2017-03-03 2018-09-05 Treos Bio Kft Immunogenic peptides
CA3086923A1 (en) 2017-12-28 2019-07-04 Gritstone Oncology, Inc. Antigen-binding proteins targeting shared antigens
WO2019222762A1 (en) 2018-05-18 2019-11-21 Children's National Medical Center Improved cell therapy compositions for hematopoietic stem cell transplant patients
CN112512538A (en) 2018-05-18 2021-03-16 国家儿童医疗中心 Improved targeted T cell therapy
GB201814361D0 (en) 2018-09-04 2018-10-17 Treos Bio Zrt Immunogenetic cancer screening test
AU2019334437A1 (en) 2018-09-04 2021-03-18 Treos Bio Limited Peptide vaccines
GB201814362D0 (en) 2018-09-04 2018-10-17 Treos Bio Zrt Composition and process for preparing vaccine
CA3126064A1 (en) 2019-01-07 2020-07-16 Children's National Medical Center Improved targeted t-cell therapy for treatment of multiple myeloma
EP3908293A4 (en) 2019-01-07 2023-01-11 Children's National Medical Center EX VIVO ACTIVATED T-LYMPHOCYTIC COMPOSITIONS AND METHODS OF USE THEREOF
GB202004974D0 (en) 2020-04-03 2020-05-20 Treos Bio Ltd Coronavirus vaccine

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100074925A1 (en) * 2006-09-21 2010-03-25 Vaxil Biotherapeutics Ltd Antigen specific multi epitope vaccines
EP2042600A1 (en) * 2007-09-28 2009-04-01 Commissariat A L'energie Atomique A public and immunogenic CD4+ T Cell epitope of the hiv tat protein and its applications
EP2745845A1 (en) * 2012-12-19 2014-06-25 Centre Hospitalier Universitaire de Bordeaux A method for preventing or treating an HIV infection
WO2015164798A1 (en) * 2014-04-25 2015-10-29 Tria Bioscience Corp. Synthetic hapten carrier compositions and methods

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
SANTORO ROSA, AIDS RESEARCH AND HUMAN RETROVIRUSES., 1 November 2015 (2015-11-01) *
SINGH SATARUDRA PRAKASH ET AL:, MAJOR HISTOCOMPATIBILITY COMPLEX LINKED DATABASES AND PREDICTION TOOLS FOR DESIGNING VACCINES, 14 November 2015 (2015-11-14) *
YAMADA AKIRA ET AL:, PHASE I CLINICAL STUDY OF A PERSONALIZED PEPTIDE VACCINATION AVAILABLE FOR SIX DIFFERENT HUMAN LEUKOCYTE ANTIGEN (HLA-A2,- A3,-A11 ,-A24,-A31 AND-A33)-POSITIVE PATIENTS WITH ADVANCED CANCER, 1 January 2011 (2011-01-01) *

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