IL258592A - Morphinan derivative and medical usage thereof - Google Patents

Morphinan derivative and medical usage thereof

Info

Publication number
IL258592A
IL258592A IL258592A IL25859218A IL258592A IL 258592 A IL258592 A IL 258592A IL 258592 A IL258592 A IL 258592A IL 25859218 A IL25859218 A IL 25859218A IL 258592 A IL258592 A IL 258592A
Authority
IL
Israel
Prior art keywords
medical usage
morphinan derivative
morphinan
derivative
usage
Prior art date
Application number
IL258592A
Other languages
Hebrew (he)
Original Assignee
Univ Tsukuba
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Tsukuba filed Critical Univ Tsukuba
Publication of IL258592A publication Critical patent/IL258592A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
IL258592A 2015-10-29 2018-04-10 Morphinan derivative and medical usage thereof IL258592A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2015212553 2015-10-29
JP2016155477 2016-08-08
PCT/JP2016/081995 WO2017073710A1 (en) 2015-10-29 2016-10-28 Morphinan derivative and medical usage thereof

Publications (1)

Publication Number Publication Date
IL258592A true IL258592A (en) 2018-06-28

Family

ID=58630476

Family Applications (1)

Application Number Title Priority Date Filing Date
IL258592A IL258592A (en) 2015-10-29 2018-04-10 Morphinan derivative and medical usage thereof

Country Status (11)

Country Link
US (1) US10377763B2 (en)
EP (1) EP3369736A4 (en)
JP (1) JP6885560B2 (en)
CN (1) CN108368122A (en)
AU (1) AU2016346558A1 (en)
BR (1) BR112018008294A2 (en)
CA (1) CA3001658A1 (en)
EA (1) EA201891054A1 (en)
IL (1) IL258592A (en)
SG (1) SG11201803191VA (en)
WO (1) WO2017073710A1 (en)

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0846694A1 (en) 1992-01-23 1998-06-10 Toray Industries, Inc. Morphinan derivative and its pharmaceutical applications
EP0663401B1 (en) 1993-07-23 2000-06-07 Toray Industries, Inc. Morphinan derivative and medicinal use
CA2270955C (en) 1997-09-02 2007-08-07 Toray Industries Inc. Pharmaceutical composition containing morphinan derivative for treating drug dependence
RU2378257C2 (en) 2004-03-01 2010-01-10 Актелион Фармасьютиклз Лтд Substituted derivatives of 1, 2, 3, 4-tetrahydroisoquinoline
PE20081229A1 (en) 2006-12-01 2008-08-28 Merck & Co Inc DIAZEPAM OREXIN RECEPTOR ANTAGONISTS REPLACED
PT2626350E (en) 2010-09-22 2015-08-03 Eisai R&D Man Co Ltd Cyclopropane compound
SG11201407255XA (en) 2012-05-29 2014-12-30 Creative Tech Ltd Stereo widening over arbitrarily-configured loudspeakers
US9694069B2 (en) 2013-03-14 2017-07-04 Alere San Diego, Inc. 6-acetylmorphine analogs, and methods for their synthesis and use
WO2016152953A1 (en) 2015-03-24 2016-09-29 東レ株式会社 Morphinan derivative and medicinal use for same

Also Published As

Publication number Publication date
EP3369736A1 (en) 2018-09-05
US10377763B2 (en) 2019-08-13
EA201891054A1 (en) 2018-10-31
JPWO2017073710A1 (en) 2018-08-23
US20180305369A1 (en) 2018-10-25
JP6885560B2 (en) 2021-06-16
AU2016346558A1 (en) 2018-04-26
BR112018008294A2 (en) 2018-10-30
SG11201803191VA (en) 2018-05-30
CN108368122A (en) 2018-08-03
WO2017073710A1 (en) 2017-05-04
CA3001658A1 (en) 2017-05-04
EP3369736A4 (en) 2019-04-24

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