IL245714B - Fluidic device for producing platelets - Google Patents

Fluidic device for producing platelets

Info

Publication number
IL245714B
IL245714B IL245714A IL24571416A IL245714B IL 245714 B IL245714 B IL 245714B IL 245714 A IL245714 A IL 245714A IL 24571416 A IL24571416 A IL 24571416A IL 245714 B IL245714 B IL 245714B
Authority
IL
Israel
Prior art keywords
fluidic device
producing platelets
platelets
producing
fluidic
Prior art date
Application number
IL245714A
Other languages
Hebrew (he)
Other versions
IL245714A0 (en
Inventor
Baruch Dominique
Pierre Marin BLIN Antoine
Magniez Aurelie
Chassac Sonia
Le Goff Anne
REYSSAT Mathilde
Original Assignee
Platod
Espci Paristech
Baruch Dominique
Pierre Marin BLIN Antoine
Magniez Aurelie
Chassac Sonia
Le Goff Anne
REYSSAT Mathilde
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Platod, Espci Paristech, Baruch Dominique, Pierre Marin BLIN Antoine, Magniez Aurelie, Chassac Sonia, Le Goff Anne, REYSSAT Mathilde filed Critical Platod
Publication of IL245714A0 publication Critical patent/IL245714A0/en
Publication of IL245714B publication Critical patent/IL245714B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0644—Platelets; Megakaryocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/19—Platelets; Megacaryocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/1023—Microstructural devices for non-optical measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0652—Sorting or classification of particles or molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0663—Stretching or orienting elongated molecules or particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0668—Trapping microscopic beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0848—Specific forms of parts of containers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/125—Stem cell factor [SCF], c-kit ligand [KL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/145—Thrombopoietin [TPO]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2521/00—Culture process characterised by the use of hydrostatic pressure, flow or shear forces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G01N2015/018—Platelets
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1028—Sorting particles

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Fluid Mechanics (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
IL245714A 2013-11-19 2016-05-18 Fluidic device for producing platelets IL245714B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13306582 2013-11-19
PCT/EP2014/074905 WO2015075030A1 (en) 2013-11-19 2014-11-18 Fluidic device for producing platelets

Publications (2)

Publication Number Publication Date
IL245714A0 IL245714A0 (en) 2016-07-31
IL245714B true IL245714B (en) 2019-03-31

Family

ID=49683655

Family Applications (1)

Application Number Title Priority Date Filing Date
IL245714A IL245714B (en) 2013-11-19 2016-05-18 Fluidic device for producing platelets

Country Status (9)

Country Link
US (1) US9909102B2 (en)
EP (1) EP3071327A1 (en)
JP (1) JP6554466B2 (en)
KR (1) KR102331655B1 (en)
CN (1) CN105980057B (en)
AU (1) AU2014352015B2 (en)
CA (1) CA2930131A1 (en)
IL (1) IL245714B (en)
WO (1) WO2015075030A1 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201210857D0 (en) 2012-06-19 2012-08-01 Cambridge Entpr Ltd Transcription factor mediated programming towards megakaryocytes
CN110579435B (en) 2012-10-15 2023-09-26 纳诺赛莱克特生物医药股份有限公司 System, apparatus and method for particle sorting
CA2896053A1 (en) 2012-12-21 2014-06-26 Ocata Therapeutics, Inc. Methods for production of platelets from pluripotent stem cells and compositions thereof
AU2013371589C1 (en) 2013-01-03 2020-09-24 Brigham And Women's Hospital, Inc. System and method for a biomimetic fluid processing
EP3126484B1 (en) 2014-03-31 2020-09-23 Brigham and Women's Hospital, Inc. Systems and methods for biomimetic fluid processing
WO2016180918A1 (en) 2015-05-12 2016-11-17 Platod Combination of pharmacological and microfluidic features for improved platelets production
WO2016205144A1 (en) * 2015-06-14 2016-12-22 Bluecircle Therapeutics, Inc. Compositions of platelet-derived theranostics and uses thereof
US10889791B2 (en) * 2015-10-16 2021-01-12 Nissan Chemical Industries, Ltd. Coating agent for flow passage
EP3372674B1 (en) * 2015-11-02 2020-10-07 Megakaryon Corporation Method for preparing platelets using reciprocating stirring device
JP6485783B2 (en) * 2016-09-29 2019-03-20 住友ゴム工業株式会社 Medical inspection apparatus and cell inspection method
JP6854879B2 (en) * 2017-03-16 2021-04-07 富士フイルム株式会社 A method for separating megakaryocytes and platelets and an instrument for separating megakaryocytes and platelets
US20200123487A1 (en) * 2017-06-20 2020-04-23 Northwestern University Microfluidic platelet bioreactor device and systems
WO2019059235A1 (en) * 2017-09-19 2019-03-28 株式会社メガカリオン Method for manufacturing purified blood platelets, method for manufacturing blood platelet preparation, method for manufacturing blood preparation, blood platelet preservation fluid, blood platelet preservation agent, and method for preserving blood platelets
JP7003640B2 (en) * 2017-12-26 2022-01-20 東ソー株式会社 Particle detector and particle detection method
BR112020013656A2 (en) 2018-01-05 2020-12-01 Platelet Biogenesis, Inc. compositions and methods for producing megakaryocytes
CN109622078B (en) * 2018-12-11 2020-09-22 西安交通大学 Micro-fluidic chip for single-position enrichment of particles in non-Newtonian fluid
CN109967016B (en) * 2019-01-23 2021-03-19 南京市江宁医院 Method for artificially synthesizing blood platelets in vitro in fluid motion mode
US20220145235A1 (en) * 2019-03-15 2022-05-12 Megakaryon Corporation Storage liquid for mammalian cells
CN111040928B (en) * 2019-12-27 2023-12-26 天津大学 High-flux micro-fluidic chip for Crypthecodinium cohnii treatment and collection
US20240084238A1 (en) 2021-02-08 2024-03-14 Hemostod Sa Use of 3d porous structure for platelet production
CN115212931B (en) * 2021-04-15 2024-06-11 武汉介观生物科技有限责任公司 Platelet in-vitro release system and platelet production method

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070196820A1 (en) * 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
HUE027112T2 (en) * 2008-12-04 2016-08-29 Inserm (Institut Nat De La Sante Et De La Rech Medicale) Method for producing platelets
JP2012519558A (en) * 2009-03-10 2012-08-30 モナッシュ ユニヴァーシティ Platelet aggregation using microfluidic devices
KR20120091631A (en) * 2011-02-09 2012-08-20 삼성전자주식회사 Microfluidic device
WO2012129109A2 (en) 2011-03-18 2012-09-27 New York Blood Center, Inc. Megakaryocyte and platelet production from stem cells
JP6108426B2 (en) 2011-06-28 2017-04-05 国立大学法人名古屋大学 Platelet production method and platelet production apparatus
US9597692B2 (en) * 2011-08-26 2017-03-21 Imec Micro-fluidic device for sorting particles, and methods for sorting particles
AU2013371589C1 (en) 2013-01-03 2020-09-24 Brigham And Women's Hospital, Inc. System and method for a biomimetic fluid processing

Also Published As

Publication number Publication date
IL245714A0 (en) 2016-07-31
KR102331655B1 (en) 2021-11-30
WO2015075030A1 (en) 2015-05-28
AU2014352015A1 (en) 2016-05-12
JP6554466B2 (en) 2019-07-31
KR20160086924A (en) 2016-07-20
CN105980057A (en) 2016-09-28
US9909102B2 (en) 2018-03-06
EP3071327A1 (en) 2016-09-28
CN105980057B (en) 2019-08-16
JP2016538859A (en) 2016-12-15
AU2014352015B2 (en) 2019-10-03
CA2930131A1 (en) 2015-05-28
US20160272941A1 (en) 2016-09-22

Similar Documents

Publication Publication Date Title
IL245714B (en) Fluidic device for producing platelets
IL256021B (en) Walker-assist device
HK1224377A1 (en) Microfluidic chip
HK1212811A1 (en) Solenoid-operated device
EP2946859A4 (en) Machining device
ZA201600315B (en) Microfluidic device
EP2950429A4 (en) Fluid device
SG2013090790A (en) A microfluidic device
ZA201604453B (en) Plasmapheresis device
EP3020508A4 (en) Machining device
SG11201602457RA (en) Microfluidic device
EP3016154A4 (en) Led device
EP2982438A4 (en) Pipette device
EP2988582A4 (en) Substrate-clamp device
SG11201507586PA (en) Microfluidic device for immunoblotting
GB201314474D0 (en) MOS-Bipolar device
PL2969215T3 (en) Microfluidic device
EP2947000A4 (en) Airship-mooring device
GB201315649D0 (en) Device
GB201310610D0 (en) Object-handling device
GB201306815D0 (en) Functional fluid
GB201303718D0 (en) Device
TWI560133B (en) Device for changing brake fluid
GB201315508D0 (en) State-changeable device
GB2519171B (en) Micro-Valve

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed