IL245414A0 - Process for the preparation of methylphenidate and pharmaceutical salts thereof - Google Patents
Process for the preparation of methylphenidate and pharmaceutical salts thereofInfo
- Publication number
- IL245414A0 IL245414A0 IL245414A IL24541416A IL245414A0 IL 245414 A0 IL245414 A0 IL 245414A0 IL 245414 A IL245414 A IL 245414A IL 24541416 A IL24541416 A IL 24541416A IL 245414 A0 IL245414 A0 IL 245414A0
- Authority
- IL
- Israel
- Prior art keywords
- methylphenidate
- preparation
- pharmaceutical salts
- pharmaceutical
- salts
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361901674P | 2013-11-08 | 2013-11-08 | |
| US201462023340P | 2014-07-11 | 2014-07-11 | |
| PCT/US2014/062795 WO2015069505A1 (en) | 2013-11-08 | 2014-10-29 | Process for the preparation of methylphenidate and pharmaceutical salts thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL245414A0 true IL245414A0 (en) | 2016-06-30 |
Family
ID=51905409
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL245414A IL245414A0 (en) | 2013-11-08 | 2016-05-01 | Process for the preparation of methylphenidate and pharmaceutical salts thereof |
| IL245415A IL245415A0 (en) | 2013-11-08 | 2016-05-01 | Process for the preparation of methylphenidate and pharmaceutical salts thereof |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL245415A IL245415A0 (en) | 2013-11-08 | 2016-05-01 | Process for the preparation of methylphenidate and pharmaceutical salts thereof |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20150133667A1 (en) |
| EP (2) | EP3066076B1 (en) |
| JP (2) | JP2016535751A (en) |
| CN (1) | CN106458894A (en) |
| CA (2) | CA2928959A1 (en) |
| DK (1) | DK3066076T3 (en) |
| ES (1) | ES2719703T3 (en) |
| HU (1) | HUE043631T2 (en) |
| IL (2) | IL245414A0 (en) |
| PT (1) | PT3066076T (en) |
| TW (2) | TW201609648A (en) |
| WO (2) | WO2015069507A1 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9682073B2 (en) | 2011-05-19 | 2017-06-20 | Gilrose Pharmaceuticals, Llc | Pre-frontal cortex processing disorder gait and limb impairments treatment |
| CA2991529C (en) * | 2015-07-08 | 2021-01-05 | Gilrose Pharmaceuticals, Llc | Pre-frontal cortex processing disorder, gait and limb impairment treatment |
| CN106349151B (en) * | 2016-08-25 | 2018-07-10 | 合肥立方制药股份有限公司 | The impurity G and its method of purification and purposes generated by methylphenidate hydrochloride preparation process |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003031411A2 (en) * | 2001-10-12 | 2003-04-17 | Sention, Inc. | Direct resolution of racemic threo-methylphenidate hydrochloride |
| WO2003033097A2 (en) * | 2001-10-17 | 2003-04-24 | E.I. Du Pont De Nemours And Company | Rotor-stator apparatus and process for the formation of particles |
| CH712083B1 (en) * | 2003-02-05 | 2017-07-31 | Siegfried Ag | Process for the preparation of d-threo-2-phenyl-2-piperidin-2-yl-acetic acid esters. |
| CN101277927A (en) * | 2005-09-29 | 2008-10-01 | 帝斯曼知识产权资产管理有限公司 | Process for esterification of an organic acid |
| US7897777B2 (en) * | 2007-01-05 | 2011-03-01 | Archimica, Inc. | Process of enantiomeric resolution of D,L-(±)-threo-methylphenidate |
| EP2376451A1 (en) * | 2009-01-09 | 2011-10-19 | Mallinckrodt LLC | Synthesis of methylphenidate and analogs thereof |
| EP2507212B1 (en) * | 2009-12-01 | 2014-04-16 | Harman Finochem Limited | Process for preparing methyl phenidate hydrochloride |
| CN102134208B (en) * | 2010-01-27 | 2014-05-14 | 爱斯特（成都）医药技术有限公司 | [R,R]-methylphenidate intermediate and analogue thereof and their synthesis and application |
| EP2651892B1 (en) * | 2010-12-17 | 2015-04-22 | Rhodes Technologies | Low-temperature synthesis of methylphenidate hydrochloride |
-
2014
- 2014-10-29 WO PCT/US2014/062800 patent/WO2015069507A1/en active Application Filing
- 2014-10-29 HU HUE14799928A patent/HUE043631T2/en unknown
- 2014-10-29 US US14/526,899 patent/US20150133667A1/en not_active Abandoned
- 2014-10-29 PT PT14799928T patent/PT3066076T/en unknown
- 2014-10-29 CA CA2928959A patent/CA2928959A1/en not_active Abandoned
- 2014-10-29 US US14/526,853 patent/US20150133668A1/en not_active Abandoned
- 2014-10-29 JP JP2016528103A patent/JP2016535751A/en active Pending
- 2014-10-29 DK DK14799928.8T patent/DK3066076T3/en active
- 2014-10-29 WO PCT/US2014/062795 patent/WO2015069505A1/en active Application Filing
- 2014-10-29 CN CN201480072471.1A patent/CN106458894A/en active Pending
- 2014-10-29 EP EP14799928.8A patent/EP3066076B1/en active Active
- 2014-10-29 EP EP14799927.0A patent/EP3066075A1/en not_active Withdrawn
- 2014-10-29 JP JP2016528099A patent/JP2016535750A/en active Pending
- 2014-10-29 CA CA2929105A patent/CA2929105A1/en not_active Abandoned
- 2014-10-29 ES ES14799928T patent/ES2719703T3/en active Active
- 2014-11-06 TW TW103138468A patent/TW201609648A/en unknown
- 2014-11-06 TW TW103138467A patent/TW201609647A/en unknown
-
2016
- 2016-05-01 IL IL245414A patent/IL245414A0/en unknown
- 2016-05-01 IL IL245415A patent/IL245415A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN106458894A (en) | 2017-02-22 |
| US20150133668A1 (en) | 2015-05-14 |
| ES2719703T3 (en) | 2019-07-12 |
| JP2016535751A (en) | 2016-11-17 |
| WO2015069505A1 (en) | 2015-05-14 |
| US20150133667A1 (en) | 2015-05-14 |
| PT3066076T (en) | 2019-05-23 |
| DK3066076T3 (en) | 2019-04-23 |
| WO2015069507A1 (en) | 2015-05-14 |
| TW201609647A (en) | 2016-03-16 |
| EP3066076A1 (en) | 2016-09-14 |
| TW201609648A (en) | 2016-03-16 |
| EP3066075A1 (en) | 2016-09-14 |
| CA2929105A1 (en) | 2015-05-14 |
| HUE043631T2 (en) | 2019-08-28 |
| IL245415A0 (en) | 2016-06-30 |
| EP3066076B1 (en) | 2019-03-27 |
| JP2016535750A (en) | 2016-11-17 |
| CA2928959A1 (en) | 2015-05-14 |
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