IL234452B - Improved stability of hydromorphone hydrochloride solutions - Google Patents

Improved stability of hydromorphone hydrochloride solutions

Info

Publication number
IL234452B
IL234452B IL234452A IL23445214A IL234452B IL 234452 B IL234452 B IL 234452B IL 234452 A IL234452 A IL 234452A IL 23445214 A IL23445214 A IL 23445214A IL 234452 B IL234452 B IL 234452B
Authority
IL
Israel
Prior art keywords
improved stability
hydromorphone hydrochloride
hydrochloride solutions
solutions
hydromorphone
Prior art date
Application number
IL234452A
Other languages
Hebrew (he)
Original Assignee
Piramal Critical Care Ltd
Mallinckrodt Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Piramal Critical Care Ltd, Mallinckrodt Llc filed Critical Piramal Critical Care Ltd
Publication of IL234452B publication Critical patent/IL234452B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0085—Brain, e.g. brain implants; Spinal cord
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
IL234452A 2012-03-07 2014-09-03 Improved stability of hydromorphone hydrochloride solutions IL234452B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261607774P 2012-03-07 2012-03-07
PCT/US2013/029328 WO2013134362A1 (en) 2012-03-07 2013-03-06 Improved stability of hydromorphone hydrochloride solutions

Publications (1)

Publication Number Publication Date
IL234452B true IL234452B (en) 2020-01-30

Family

ID=48045027

Family Applications (1)

Application Number Title Priority Date Filing Date
IL234452A IL234452B (en) 2012-03-07 2014-09-03 Improved stability of hydromorphone hydrochloride solutions

Country Status (8)

Country Link
EP (1) EP2822535A1 (en)
JP (1) JP6074442B2 (en)
KR (1) KR101710244B1 (en)
CN (1) CN104244925B (en)
CA (1) CA2865815C (en)
IL (1) IL234452B (en)
MX (1) MX361779B (en)
WO (1) WO2013134362A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9155734B2 (en) * 2012-03-07 2015-10-13 Mallinckrodt Llc Stability of hydromorphone hydrochloride solutions

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2233280A1 (en) * 1995-09-29 1997-04-03 Peter Rothbart Sustained release delivery system and long acting narcotic analgesics and antagonists
US20040102476A1 (en) * 2002-11-25 2004-05-27 Chan Tai Wah High concentration formulations of opioids and opioid derivatives
WO2010098897A1 (en) * 2009-02-26 2010-09-02 Teikoku Pharma Usa, Inc. Narcotic emulsion formulations for treatment of cancer pain
WO2011019954A2 (en) * 2009-08-13 2011-02-17 Yehuda Ivri Intracochlear drug delivery to the central nervous system
ES2444591T3 (en) * 2010-10-28 2014-02-25 Acino Pharma Ag Medication with the active substance hydromorphone with improved storage stability

Also Published As

Publication number Publication date
KR20140132765A (en) 2014-11-18
MX2014010622A (en) 2014-11-14
EP2822535A1 (en) 2015-01-14
CN104244925A (en) 2014-12-24
CN104244925B (en) 2017-03-29
MX361779B (en) 2018-12-17
WO2013134362A1 (en) 2013-09-12
KR101710244B1 (en) 2017-02-24
CA2865815A1 (en) 2013-09-12
CA2865815C (en) 2017-06-13
JP6074442B2 (en) 2017-02-01
JP2015509541A (en) 2015-03-30

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Legal Events

Date Code Title Description
FF Patent granted
MM9K Patent not in force due to non-payment of renewal fees