IL230506A0 - A process for preparing peripheral opioid inhibitory compounds and their intermediates - Google Patents
A process for preparing peripheral opioid inhibitory compounds and their intermediatesInfo
- Publication number
- IL230506A0 IL230506A0 IL230506A IL23050614A IL230506A0 IL 230506 A0 IL230506 A0 IL 230506A0 IL 230506 A IL230506 A IL 230506A IL 23050614 A IL23050614 A IL 23050614A IL 230506 A0 IL230506 A0 IL 230506A0
- Authority
- IL
- Israel
- Prior art keywords
- intermediates
- processes
- preparation
- opioid antagonist
- antagonist compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161508817P | 2011-07-18 | 2011-07-18 | |
| PCT/US2012/047082 WO2013012871A1 (en) | 2011-07-18 | 2012-07-17 | Processes for the preparation of peripheral opioid antagonist compounds and intermediates thereto |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL230506A0 true IL230506A0 (en) | 2014-03-31 |
Family
ID=47558430
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL230506A IL230506A0 (en) | 2011-07-18 | 2014-01-16 | A process for preparing peripheral opioid inhibitory compounds and their intermediates |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20150045556A1 (enExample) |
| EP (1) | EP2734041A4 (enExample) |
| CN (1) | CN103917096A (enExample) |
| AU (1) | AU2012284127A1 (enExample) |
| CA (1) | CA2842183A1 (enExample) |
| HK (1) | HK1199794A1 (enExample) |
| IL (1) | IL230506A0 (enExample) |
| IN (1) | IN2014DN00137A (enExample) |
| WO (1) | WO2013012871A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103804431A (zh) * | 2014-02-25 | 2014-05-21 | 中国人民解放军第四军医大学 | 一种手性二茂铁双膦配体及其制备方法 |
| EP3421455B1 (en) * | 2017-06-29 | 2019-03-27 | F.I.S.- Fabbrica Italiana Sintetici S.p.A. | Improved process for the preparation of chiral 3-amino-piperidins, useful intermediates for the preparation of tofacitinib |
| MA49752A (fr) | 2017-08-02 | 2021-04-21 | Vertex Pharma | Procédés de préparation de composés de pyrrolidine |
| KR102716244B1 (ko) | 2017-12-08 | 2024-10-14 | 버텍스 파마슈티칼스 인코포레이티드 | 낭포성 섬유증 막횡단 전도 조절자의 조정제의 제조 방법 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ224236A (en) * | 1987-04-16 | 1990-08-28 | Lilly Co Eli | Trans 3,4 pyridine derivatives and pharmaceutical compositions |
| US5536858A (en) * | 1994-02-12 | 1996-07-16 | Hoffmann-La Roche Inc. | Tetrasulfonated diphosphine compounds and metal complexes thereof for asymmetric catalytic reactions |
| US5553858A (en) * | 1995-06-28 | 1996-09-10 | Mckoon; Carl T. | Golf putter |
| US6057456A (en) * | 1997-10-16 | 2000-05-02 | Yale University | Transition metal-catalyzed process for preparing alpha-arylated carbonyl-containing compounds |
| US6900228B1 (en) * | 1998-03-10 | 2005-05-31 | Research Triangle Institute | Opiate compounds, methods of making and methods of use |
| TWI254043B (en) * | 1999-06-08 | 2006-05-01 | Hoffmann La Roche | Ethanesulfonyl-piperidine derivatives having good affinity to N-methyl-D-aspartate (NMDA) receptor |
| US6794510B2 (en) * | 2002-08-08 | 2004-09-21 | Adolor Corporation | Processes for the preparation of peripheral opioid antagonist compounds and intermediates thereto |
| SG172225A1 (en) * | 2008-12-18 | 2011-07-28 | Hoffmann La Roche | Process for synthesis of amino-methyl tetraline derivatives |
-
2012
- 2012-07-17 IN IN137DEN2014 patent/IN2014DN00137A/en unknown
- 2012-07-17 CA CA2842183A patent/CA2842183A1/en not_active Withdrawn
- 2012-07-17 WO PCT/US2012/047082 patent/WO2013012871A1/en not_active Ceased
- 2012-07-17 EP EP12814994.5A patent/EP2734041A4/en not_active Withdrawn
- 2012-07-17 CN CN201280045401.8A patent/CN103917096A/zh active Pending
- 2012-07-17 HK HK15100253.5A patent/HK1199794A1/xx unknown
- 2012-07-17 AU AU2012284127A patent/AU2012284127A1/en not_active Abandoned
- 2012-07-17 US US14/233,670 patent/US20150045556A1/en not_active Abandoned
-
2014
- 2014-01-16 IL IL230506A patent/IL230506A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2842183A1 (en) | 2013-01-24 |
| IN2014DN00137A (enExample) | 2015-05-22 |
| AU2012284127A1 (en) | 2013-05-02 |
| US20150045556A1 (en) | 2015-02-12 |
| EP2734041A4 (en) | 2015-03-25 |
| HK1199794A1 (en) | 2015-07-24 |
| CN103917096A (zh) | 2014-07-09 |
| WO2013012871A1 (en) | 2013-01-24 |
| EP2734041A1 (en) | 2014-05-28 |
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