IL220680A - Compounds as bradykinin b1 antagonists - Google Patents

Compounds as bradykinin b1 antagonists

Info

Publication number
IL220680A
IL220680A IL220680A IL22068012A IL220680A IL 220680 A IL220680 A IL 220680A IL 220680 A IL220680 A IL 220680A IL 22068012 A IL22068012 A IL 22068012A IL 220680 A IL220680 A IL 220680A
Authority
IL
Israel
Prior art keywords
bradykinin
antagonists
compounds
Prior art date
Application number
IL220680A
Other languages
Hebrew (he)
Other versions
IL220680A0 (en
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2010/052232 external-priority patent/WO2010097372A1/en
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of IL220680A0 publication Critical patent/IL220680A0/en
Publication of IL220680A publication Critical patent/IL220680A/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50Pyridazines; Hydrogenated pyridazines
    • A61K31/501Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00Compounds containing amino groups bound to a carbon skeleton
    • C07C211/43Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C211/54Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to two or three six-membered aromatic rings
    • C07C211/56Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to two or three six-membered aromatic rings the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72Nitrogen atoms
    • C07D213/74Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D237/00Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/24Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/24Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IL220680A 2010-02-23 2012-06-28 Compounds as bradykinin b1 antagonists IL220680A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/EP2010/052232 WO2010097372A1 (en) 2009-02-26 2010-02-23 Compounds as bradykinin b1 antagonists
PCT/EP2011/052512 WO2011104203A1 (en) 2010-02-23 2011-02-21 Compounds as bradykinin b1 antagonists

Publications (2)

Publication Number Publication Date
IL220680A0 IL220680A0 (en) 2012-08-30
IL220680A true IL220680A (en) 2015-08-31

Family

ID=43981434

Family Applications (1)

Application Number Title Priority Date Filing Date
IL220680A IL220680A (en) 2010-02-23 2012-06-28 Compounds as bradykinin b1 antagonists

Country Status (23)

Country Link
EP (1) EP2539323B3 (en)
JP (1) JP5603955B2 (en)
KR (1) KR101843341B1 (en)
CN (2) CN102781916B (en)
AP (1) AP3218A (en)
AR (1) AR080249A1 (en)
AU (1) AU2011219885C1 (en)
CA (1) CA2790952C (en)
CY (1) CY1116182T1 (en)
DK (1) DK2539323T6 (en)
ES (1) ES2531663T7 (en)
HK (1) HK1175171A1 (en)
IL (1) IL220680A (en)
MA (1) MA34008B1 (en)
MX (1) MX2012009224A (en)
NZ (1) NZ601194A (en)
PE (1) PE20121805A1 (en)
PL (1) PL2539323T6 (en)
PT (1) PT2539323E (en)
SG (1) SG183336A1 (en)
SI (1) SI2539323T1 (en)
TW (1) TWI499589B (en)
WO (1) WO2011104203A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102007034620A1 (en) 2007-07-25 2009-01-29 Boehringer Ingelheim Pharma Gmbh & Co. Kg New B1 antagonists
JP5238812B2 (en) 2007-08-29 2013-07-17 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Novel bradykinin B1 antagonist
EP2539323B3 (en) 2010-02-23 2017-10-04 Boehringer Ingelheim International GmbH Compounds as bradykinin B1 antagonists
US8937073B2 (en) * 2010-08-20 2015-01-20 Boehringer Ingelheim International Gmbh Disubstituted tetrahydrofuranyl compounds and their use as B1-receptor antagonists
JP5727010B2 (en) * 2010-08-20 2015-06-03 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Pyridazine derivatives as antagonists of the bradykinin B1 receptor
JP7376582B2 (en) * 2018-10-22 2023-11-08 イーオーイー オレオ ゲーエムベーハー Additive for powder materials for compression into compacts
WO2021198534A1 (en) 2020-04-04 2021-10-07 Oxurion NV Plasma kallikrein inhibitors for use in the treatment of coronaviral disease
WO2023148016A1 (en) 2022-02-04 2023-08-10 Oxurion NV Biomarker for plasma kallikrein inhibitor therapy response

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR038377A1 (en) * 2002-02-08 2005-01-12 Merck & Co Inc DERIVATIVES OF N-BIFENIL-AMINOCICLOALCANCARBOXAMIDA (WITH REPLACEMENT WITH METHYL)
IL166426A0 (en) * 2002-08-29 2006-01-15 Merck & Co Inc N-biarylmethyl aminocycloalkanecarboxamide derivatives
CA2534188A1 (en) 2003-08-07 2005-02-24 Merck & Co., Inc. Sulfonyl substituted n-(biarylmethyl) aminocyclopropanecarboxamides
CN1926136A (en) * 2004-03-02 2007-03-07 默克公司 Amino cyclopropane carboxamide derivatives as bradykinin antagonists
CN101171005A (en) 2005-05-11 2008-04-30 尼科梅德有限责任公司 Combination of a pde4 inhibitor and a tetrahydrobiopterin derivative
HUP0600809A3 (en) * 2006-10-27 2008-09-29 Richter Gedeon Nyrt New phenylsulfamoyl-benzamide derivatives as bradykinin antagonists, process and intermediates for their preparation and pharmaceutical compositions containing them
EP2539323B3 (en) 2010-02-23 2017-10-04 Boehringer Ingelheim International GmbH Compounds as bradykinin B1 antagonists
PE20120360A1 (en) 2009-02-26 2012-04-14 Boehringer Ingelheim Int BRADIQUININ B1 ANTAGONIST QUALITY COMPOUNDS

Also Published As

Publication number Publication date
CN103980258A (en) 2014-08-13
MA34008B1 (en) 2013-02-01
CA2790952A1 (en) 2011-09-01
PE20121805A1 (en) 2013-01-23
PL2539323T6 (en) 2018-05-30
EP2539323A1 (en) 2013-01-02
PT2539323E (en) 2015-02-16
CN102781916A (en) 2012-11-14
EP2539323B3 (en) 2017-10-04
AR080249A1 (en) 2012-03-21
AU2011219885B2 (en) 2015-10-15
KR20130025864A (en) 2013-03-12
AP2012006330A0 (en) 2012-06-30
CN103980258B (en) 2016-09-07
ES2531663T7 (en) 2018-02-13
AP3218A (en) 2015-04-30
CY1116182T1 (en) 2017-02-08
NZ601194A (en) 2014-10-31
DK2539323T6 (en) 2018-01-02
JP2013519710A (en) 2013-05-30
TWI499589B (en) 2015-09-11
KR101843341B1 (en) 2018-03-30
TW201141848A (en) 2011-12-01
JP5603955B2 (en) 2014-10-08
SG183336A1 (en) 2012-09-27
AU2011219885C1 (en) 2017-06-29
SI2539323T1 (en) 2015-03-31
HK1175171A1 (en) 2013-06-28
DK2539323T3 (en) 2015-02-23
CN102781916B (en) 2014-06-25
CA2790952C (en) 2017-07-04
MX2012009224A (en) 2012-08-23
AU2011219885A1 (en) 2012-08-02
IL220680A0 (en) 2012-08-30
EP2539323B1 (en) 2014-12-03
PL2539323T3 (en) 2015-05-29
ES2531663T3 (en) 2015-03-18
WO2011104203A1 (en) 2011-09-01

Similar Documents

Publication Publication Date Title
HRP20181788T1 (en) Substituted pyridinone-pyridinyl compounds
AP3391A (en) 2-Amino-4-arylthiazole compounds as TROA1 antagonists
HRP20150167T1 (en) Compounds as bradykinin b1 antagonists
EP2590647A4 (en) Pro-neurogenic compounds
GB201008134D0 (en) Compounds
GB201007347D0 (en) Compounds
EP2605658A4 (en) Spiroxazolidinone compounds
HK1175171A1 (en) Compounds as bradykinin b1 antagonists b1
EP2649050A4 (en) Compounds
GB201002563D0 (en) Compounds
GB201008209D0 (en) Compounds
GB201001688D0 (en) Compounds
GB201002216D0 (en) Compounds
GB201008210D0 (en) Compounds
GB201001796D0 (en) Compounds
HK1200443A1 (en) Compounds as bradykinin b1 antagonists b1
GB201009669D0 (en) Compounds
GB201008291D0 (en) Compounds
GB201006216D0 (en) Compounds
GB201005821D0 (en) Immunomoduatory compounds
GB201005727D0 (en) Compounds
GB201005584D0 (en) Compounds
GB201002708D0 (en) Compounds
GB201001418D0 (en) Compounds
GB201000831D0 (en) Compounds

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees