IL195959A0 - Metformin r-(+)lipoate as an antidiabetic agent for control of diabetic hyperglycemia and diabetic complications - Google Patents
Metformin r-(+)lipoate as an antidiabetic agent for control of diabetic hyperglycemia and diabetic complicationsInfo
- Publication number
- IL195959A0 IL195959A0 IL195959A IL19595908A IL195959A0 IL 195959 A0 IL195959 A0 IL 195959A0 IL 195959 A IL195959 A IL 195959A IL 19595908 A IL19595908 A IL 19595908A IL 195959 A0 IL195959 A0 IL 195959A0
- Authority
- IL
- Israel
- Prior art keywords
- diabetic
- lipoate
- metformin
- control
- antidiabetic agent
- Prior art date
Links
- 208000002249 Diabetes Complications Diseases 0.000 title 1
- 206010012655 Diabetic complications Diseases 0.000 title 1
- 229940125708 antidiabetic agent Drugs 0.000 title 1
- 239000003472 antidiabetic agent Substances 0.000 title 1
- 206010012601 diabetes mellitus Diseases 0.000 title 1
- 201000001421 hyperglycemia Diseases 0.000 title 1
- AGBQKNBQESQNJD-UHFFFAOYSA-M lipoate Chemical compound [O-]C(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-M 0.000 title 1
- 230000000598 lipoate effect Effects 0.000 title 1
- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical compound CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 title 1
- 229960003105 metformin Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
- C07D339/02—Five-membered rings
- C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Ophthalmology & Optometry (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81425006P | 2006-06-16 | 2006-06-16 | |
| PCT/US2007/014034 WO2007149313A1 (en) | 2006-06-16 | 2007-06-14 | Metformin r-(+) lipoate as an antidiabetic agent for control of diabetic hyperglycemia and diabetic complications |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL195959A0 true IL195959A0 (en) | 2009-09-22 |
Family
ID=38669506
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL195959A IL195959A0 (en) | 2006-06-16 | 2008-12-15 | Metformin r-(+)lipoate as an antidiabetic agent for control of diabetic hyperglycemia and diabetic complications |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7973073B2 (https=) |
| EP (1) | EP2046773A1 (https=) |
| JP (1) | JP2009541220A (https=) |
| CN (1) | CN101522658A (https=) |
| AR (1) | AR061500A1 (https=) |
| CA (1) | CA2691775A1 (https=) |
| CL (1) | CL2007001759A1 (https=) |
| IL (1) | IL195959A0 (https=) |
| TW (1) | TW200816986A (https=) |
| WO (1) | WO2007149313A1 (https=) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8147816B2 (en) * | 2000-08-16 | 2012-04-03 | Encore Health, Llc | Presbyopia treatment by lens alteration |
| US20050112113A1 (en) * | 2000-08-16 | 2005-05-26 | Till Jonathan S. | Presbyopia treatment by lens alteration |
| US7914815B2 (en) * | 2000-08-16 | 2011-03-29 | Encore Health, Llc | Method for delivery of pharmaceuticals for treating or preventing presbyopia |
| US7935332B2 (en) * | 2000-08-16 | 2011-05-03 | Encore Health, Llc | Presbyopia treatment by lens alteration |
| US8697109B2 (en) | 2000-08-16 | 2014-04-15 | Encore Health, Llc | Caged mercaptan and seleno-mercaptan compounds and methods of using them |
| US8647612B2 (en) * | 2008-03-05 | 2014-02-11 | Encore Health, Llc | Dithiol compounds, derivatives, and treatment of presbyopia |
| US8102027B2 (en) * | 2007-08-21 | 2012-01-24 | Broadcom Corporation | IC package sacrificial structures for crack propagation confinement |
| WO2009111037A2 (en) * | 2008-03-04 | 2009-09-11 | Indigene Pharmaceuticals Inc. | Compositions and methods for treating nos-associated diseases |
| WO2009111635A2 (en) | 2008-03-05 | 2009-09-11 | Encore Health, Llc | Dithiol compounds, derivatives, and uses therefor |
| US9044439B2 (en) | 2008-03-05 | 2015-06-02 | Encore Health, Llc | Low dose lipoic and pharmaceutical compositions and methods |
| CN102159539B (zh) * | 2008-06-26 | 2014-04-16 | 矽烷实验室股份公司 | 用于血糖控制的新型二甲双胍甘氨酸盐 |
| US20100099751A1 (en) * | 2008-10-21 | 2010-04-22 | Al-Mulla Fahd | Method of treating diabetes-related vascular complications |
| US8222432B2 (en) * | 2008-10-24 | 2012-07-17 | Biolink Life Sciences, Inc. | Stable, water-insoluble R-(+)-α-lipoic acid salt useful for the treatment of diabetes mellitus and its co-morbidities |
| EP3069612A3 (en) | 2009-06-15 | 2016-10-19 | Encore Health, LLC | Dithiol compounds, derivatives, and uses therefor |
| EP2821405B1 (en) | 2009-06-15 | 2016-04-13 | Encore Health, LLC | Choline esters for treating presbyopia and cataract |
| WO2011130719A2 (en) | 2010-04-15 | 2011-10-20 | The Regents Of The University Of Michigan | A biosynthetic pathway for heterologous expression of a nonribosomal peptide synthetase drug and analogs |
| IT1399923B1 (it) * | 2010-05-11 | 2013-05-09 | Cbb Net S A | Procedimento di preparazione di sali dell'acido (r) alfa-lipoico loro formulazione ed uso nelle composizioni farmaceutiche in forma di compresse che li contengono |
| US20120178813A1 (en) | 2011-01-12 | 2012-07-12 | Thetis Pharmaceuticals Llc | Lipid-lowering antidiabetic agent |
| US8440723B2 (en) * | 2011-05-11 | 2013-05-14 | Banavara L. Mylari | Metformin salts of salicylic acid and its congeners |
| US9382187B2 (en) | 2012-07-10 | 2016-07-05 | Thetis Pharmaceuticals Llc | Tri-salt form of metformin |
| US8765811B2 (en) | 2012-07-10 | 2014-07-01 | Thetis Pharmaceuticals Llc | Tri-salt form of metformin |
| US8853259B2 (en) * | 2013-02-07 | 2014-10-07 | Banavara L. Mylari | Metformin derivatives for treating diabetes and diabetes complications |
| WO2015022613A1 (en) * | 2013-08-11 | 2015-02-19 | Mahesh Kandula | Compositions and methods for the treatment of diabetes and pre-diabetes |
| US20150073057A1 (en) * | 2013-09-06 | 2015-03-12 | Biokier, Inc. | Composition and method for treatment of diabetes |
| CA2941518A1 (en) | 2014-03-03 | 2015-09-11 | Encore Vision, Inc. | Lipoic acid choline ester compositions and methods of use |
| WO2015171516A1 (en) | 2014-05-05 | 2015-11-12 | Thetis Pharmaceuticals Llc | Compositions and methods relating to ionic salts of peptides |
| CA2951923A1 (en) | 2014-06-18 | 2015-12-23 | Thetis Pharmaceuticals Llc | Mineral amino-acid complexes of active agents |
| US9242008B2 (en) | 2014-06-18 | 2016-01-26 | Thetis Pharmaceuticals Llc | Mineral amino-acid complexes of fatty acids |
| ES2827796T3 (es) | 2016-06-03 | 2021-05-24 | Thetis Pharmaceuticals Llc | Composiciones y procedimientos relativos a sales de mediadores pro-resolutivos especializados de inflamación |
| CA3081553C (en) * | 2017-11-17 | 2022-11-15 | Cellix Bio Private Limited | Compositions and methods for the treatment of eye disorders |
| IL274233B2 (en) | 2017-11-17 | 2024-04-01 | Cellix Bio Private Ltd | Compounds, compositions and methods for treatment of eye disorders and skin diseases |
| CN110037998A (zh) * | 2018-01-16 | 2019-07-23 | 镇学初 | 二甲双胍盐在治疗脑梗死中的用途 |
| CN110294738A (zh) * | 2019-07-22 | 2019-10-01 | 通化师范学院 | 硫辛酸衍生物及其制备方法和用途 |
| CN113105367B (zh) | 2021-03-30 | 2022-08-02 | 广州大学 | 一类二甲双胍盐及其制备方法和应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6197340B1 (en) | 1998-05-28 | 2001-03-06 | Medical Research Institute | Controlled release lipoic acid |
| US20050085498A1 (en) * | 1998-05-28 | 2005-04-21 | Byrd Edward A. | Oral formulation of lipid soluble thiamine, lipoic acid, creatine derivative, and L-arginine alpha-ketoglutarate |
| FR2796551B1 (fr) * | 1999-07-23 | 2003-07-25 | Lipha | Nouveaux sels de metformine, leur procede d'obtention et les compositions pharmaceutiques en renfermant |
| US6693094B2 (en) * | 2001-03-22 | 2004-02-17 | Chrono Rx Llc | Biguanide and sulfonylurea formulations for the prevention and treatment of insulin resistance and type 2 diabetes mellitus |
| AU2003211131A1 (en) | 2002-02-14 | 2003-09-04 | Sonus Pharmaceuticals, Inc. | Metformin salts of lipophilic acids |
-
2007
- 2007-06-14 CN CNA2007800302762A patent/CN101522658A/zh active Pending
- 2007-06-14 EP EP07796141A patent/EP2046773A1/en not_active Withdrawn
- 2007-06-14 WO PCT/US2007/014034 patent/WO2007149313A1/en not_active Ceased
- 2007-06-14 US US11/818,909 patent/US7973073B2/en not_active Expired - Fee Related
- 2007-06-14 CA CA002691775A patent/CA2691775A1/en not_active Abandoned
- 2007-06-14 JP JP2009515506A patent/JP2009541220A/ja not_active Withdrawn
- 2007-06-15 AR ARP070102661A patent/AR061500A1/es unknown
- 2007-06-15 TW TW096121712A patent/TW200816986A/zh unknown
- 2007-06-15 CL CL200701759A patent/CL2007001759A1/es unknown
-
2008
- 2008-12-15 IL IL195959A patent/IL195959A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2009541220A (ja) | 2009-11-26 |
| TW200816986A (en) | 2008-04-16 |
| CN101522658A (zh) | 2009-09-02 |
| CA2691775A1 (en) | 2007-12-27 |
| CL2007001759A1 (es) | 2008-10-24 |
| WO2007149313A1 (en) | 2007-12-27 |
| EP2046773A1 (en) | 2009-04-15 |
| AR061500A1 (es) | 2008-09-03 |
| US7973073B2 (en) | 2011-07-05 |
| US20070293562A1 (en) | 2007-12-20 |
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