IL188178A0 - Pure and stable tiotropium bromide - Google Patents

Pure and stable tiotropium bromide

Info

Publication number
IL188178A0
IL188178A0 IL188178A IL18817807A IL188178A0 IL 188178 A0 IL188178 A0 IL 188178A0 IL 188178 A IL188178 A IL 188178A IL 18817807 A IL18817807 A IL 18817807A IL 188178 A0 IL188178 A0 IL 188178A0
Authority
IL
Israel
Prior art keywords
pure
tiotropium bromide
stable tiotropium
stable
bromide
Prior art date
Application number
IL188178A
Original Assignee
Sicor Inc
Diulgheroff Nicola
Pontiroli Alessandro
Scarpitta Francesca
Volonte Roberta
Casalone Roberto
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sicor Inc, Diulgheroff Nicola, Pontiroli Alessandro, Scarpitta Francesca, Volonte Roberta, Casalone Roberto filed Critical Sicor Inc
Publication of IL188178A0 publication Critical patent/IL188178A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IL188178A 2005-12-19 2007-12-17 Pure and stable tiotropium bromide IL188178A0 (en)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US75267205P 2005-12-19 2005-12-19
US75453005P 2005-12-27 2005-12-27
US76143706P 2006-01-23 2006-01-23
US77405106P 2006-02-15 2006-02-15
US78031006P 2006-03-07 2006-03-07
US83023106P 2006-07-10 2006-07-10
US83218906P 2006-07-20 2006-07-20
US83520006P 2006-08-03 2006-08-03
US83520106P 2006-08-03 2006-08-03
US83603706P 2006-08-07 2006-08-07
US85122306P 2006-10-12 2006-10-12
US85274006P 2006-10-18 2006-10-18
PCT/US2006/048690 WO2007075838A2 (en) 2005-12-19 2006-12-19 Pure and stable tiotropium bromide

Publications (1)

Publication Number Publication Date
IL188178A0 true IL188178A0 (en) 2008-03-20

Family

ID=38105786

Family Applications (1)

Application Number Title Priority Date Filing Date
IL188178A IL188178A0 (en) 2005-12-19 2007-12-17 Pure and stable tiotropium bromide

Country Status (9)

Country Link
EP (1) EP1966196A2 (en)
JP (1) JP2008530251A (en)
KR (1) KR20080079586A (en)
CN (1) CN101360744A (en)
CA (1) CA2620142A1 (en)
IL (1) IL188178A0 (en)
MX (1) MX2007009987A (en)
TW (1) TW200734333A (en)
WO (1) WO2007075838A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5822831B2 (en) 2009-08-07 2015-11-24 ジェネリクス・［ユーケー］・リミテッド Tiotropium bromide anhydride
WO2011015883A1 (en) * 2009-08-07 2011-02-10 Generics [Uk] Limited Dichloromethane solvate of tiotropium bromide and its use
WO2011095800A2 (en) * 2010-02-02 2011-08-11 Generics [Uk] Limited Analytical methods
CN101863885B (en) * 2010-06-03 2012-05-30 南京金丹呈医药技术有限公司 Method for preparing tiotropium bromide
TR201101897A2 (en) * 2011-02-28 2012-09-21 Bi̇lgi̇ç Mahmut Crystal material containing tiotropium bromide
CZ304368B6 (en) 2011-11-28 2014-04-02 Zentiva, K.S. Tiotropium bromide mixed solvate and process for preparing thereof
CN103130798B (en) * 2011-11-30 2015-12-02 连云港润众制药有限公司 The crystallization of tiotropium bromide
PT106142B (en) * 2012-02-10 2014-07-18 Hovione Farmaci Ncia S A PROCESS FOR THE PREPARATION OF TIOTROPE BROMIDE
EP2789611A1 (en) * 2013-04-08 2014-10-15 Cerbios-Pharma S.A. A crystalline form of tiotropium bromide

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1292281B1 (en) * 2000-10-12 2004-09-08 Boehringer Ingelheim Pharma GmbH & Co.KG Novel tiotropium-containing inhalation powder
CZ301841B6 (en) * 2000-10-12 2010-07-07 Boehringer Ingelheim Pharma Gmbh & Co. Kg Thiotropium bromide crystalline monohydrate, process of its preparation and its use for the preparation of a medicament
DE10064816A1 (en) * 2000-12-22 2002-06-27 Boehringer Ingelheim Pharma Production of tiotropium bromide useful as an anticholinergic comprises oxidation of di-(2-thienyl)-glycolic acid tropenol ester and subsequent quaternisation
EP2083007B1 (en) * 2003-11-03 2013-04-24 Boehringer Ingelheim International Gmbh Tiotropium salts, method for creating same and medicinal formulations containing same
SI1881980T1 (en) * 2005-05-02 2012-12-31 Boehringer Ingelheim International Gmbh Novel crystalline forms of tiotropium bromide
AU2006243239A1 (en) * 2005-05-02 2006-11-09 Boehringer Ingelheim International Gmbh Crystalline forms of tiotropium bromide

Also Published As

Publication number Publication date
CA2620142A1 (en) 2007-07-05
EP1966196A2 (en) 2008-09-10
WO2007075838A2 (en) 2007-07-05
JP2008530251A (en) 2008-08-07
TW200734333A (en) 2007-09-16
MX2007009987A (en) 2007-10-02
WO2007075838A3 (en) 2007-08-16
KR20080079586A (en) 2008-09-01
CN101360744A (en) 2009-02-04

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