IL177511A0 - Process for the synthesis of a cxcr4 antagonist - Google Patents
Process for the synthesis of a cxcr4 antagonistInfo
- Publication number
- IL177511A0 IL177511A0 IL177511A IL17751106A IL177511A0 IL 177511 A0 IL177511 A0 IL 177511A0 IL 177511 A IL177511 A IL 177511A IL 17751106 A IL17751106 A IL 17751106A IL 177511 A0 IL177511 A0 IL 177511A0
- Authority
- IL
- Israel
- Prior art keywords
- synthesis
- cxcr4 antagonist
- cxcr4
- antagonist
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/40—Nitrogen atoms attached in position 8
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55358904P | 2004-03-15 | 2004-03-15 | |
| PCT/US2005/008268 WO2005090308A1 (en) | 2004-03-15 | 2005-03-11 | Process for the synthesis of a cxcr4 antagonist |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL177511A0 true IL177511A0 (en) | 2006-12-10 |
| IL177511A IL177511A (en) | 2010-12-30 |
Family
ID=34993619
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL177511A IL177511A (en) | 2004-03-15 | 2006-08-16 | Process for the synthesis of a cxcr4 antagonist |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7332605B2 (en) |
| EP (1) | EP1730113B1 (en) |
| JP (1) | JP4870660B2 (en) |
| KR (1) | KR20060131899A (en) |
| CN (1) | CN1930127B (en) |
| AU (1) | AU2005224079A1 (en) |
| BR (1) | BRPI0508703B8 (en) |
| CA (1) | CA2558389C (en) |
| ES (1) | ES2614508T3 (en) |
| IL (1) | IL177511A (en) |
| NO (1) | NO20064200L (en) |
| RU (1) | RU2006136381A (en) |
| WO (1) | WO2005090308A1 (en) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7354932B2 (en) | 2001-12-21 | 2008-04-08 | Anormed, Inc. | Chemokine receptor binding heterocyclic compounds with enhanced efficacy |
| EP1789045A2 (en) * | 2004-08-16 | 2007-05-30 | Smithkline Beecham Corporation | Chemical compounds |
| TW200619206A (en) * | 2004-09-29 | 2006-06-16 | Anormed Inc | Chemokine-binding heterocyclic compound salts, and methods of use thereof |
| JP2009524689A (en) * | 2006-01-25 | 2009-07-02 | スミスクライン ビーチャム コーポレーション | Compound |
| US20100280010A1 (en) * | 2006-01-25 | 2010-11-04 | Kristjan Gudmundsson | Chemical compounds |
| MX2009001272A (en) * | 2006-08-02 | 2009-02-11 | Genzyme Corp | Combination therapy. |
| EP2209766A1 (en) * | 2007-04-26 | 2010-07-28 | Dr. Reddy's Laboratories (EU) Limited | Novel aldehyde composition |
| FR2934859B1 (en) * | 2008-08-05 | 2010-08-13 | Servier Lab | NEW PROCESS FOR THE SYNTHESIS OF AGOMELATIN |
| ME02663B (en) | 2010-10-06 | 2017-06-20 | Glaxosmithkline Llc | Benzimidazole derivatives as pi3 kinase inhibitors |
| ES2907489T3 (en) | 2015-12-14 | 2022-04-25 | X4 Pharmaceuticals Inc | Cancer treatment methods |
| CN109069486A (en) | 2015-12-14 | 2018-12-21 | X4 制药有限公司 | The method for the treatment of cancer |
| DK3393468T3 (en) | 2015-12-22 | 2022-12-19 | X4 Pharmaceuticals Inc | Methods for treating an immunodeficiency disease |
| GB201604213D0 (en) * | 2016-03-11 | 2016-04-27 | Proximagen Ltd | Drug combination and its use in therapy |
| US11337969B2 (en) | 2016-04-08 | 2022-05-24 | X4 Pharmaceuticals, Inc. | Methods for treating cancer |
| CN109641838A (en) | 2016-06-21 | 2019-04-16 | X4 制药有限公司 | CXCR4 inhibitor and application thereof |
| CN116554168A (en) | 2016-06-21 | 2023-08-08 | X4 制药有限公司 | CXCR4 inhibitors and uses thereof |
| CA3027495A1 (en) | 2016-06-21 | 2017-12-28 | X4 Pharmaceuticals, Inc. | Cxcr4 inhibitors and uses thereof |
| US10548889B1 (en) * | 2018-08-31 | 2020-02-04 | X4 Pharmaceuticals, Inc. | Compositions of CXCR4 inhibitors and methods of preparation and use |
| WO2022113069A1 (en) | 2020-11-24 | 2022-06-02 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | E protein channel blockers and orf3 inhibitors as anti-covid-19 agents |
| JP2023524522A (en) | 2020-05-01 | 2023-06-12 | イッサム リサーチ デベロップメント カンパニー オブ ザ ヘブリュー ユニバーシティー オブ エルサレム エルティーディー． | E protein channel blockers and ORF3 inhibitors as anti-COVID-19 agents |
| MX2024004165A (en) * | 2021-10-07 | 2024-05-10 | X4 Pharmaceuticals Inc | Synthesis of mavorixafor and intermediates thereof. |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9126677D0 (en) | 1991-12-16 | 1992-02-12 | Johnson Matthey Plc | Improvements in chemical compounds |
| GB9400411D0 (en) | 1994-01-11 | 1994-03-09 | Johnson Matthey Plc | Improvements in chemical compounds |
| GB9511357D0 (en) | 1995-06-06 | 1995-08-02 | Johnson Matthey Plc | Improved antiviral compounds |
| JP4209472B2 (en) * | 1997-06-02 | 2009-01-14 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | (Imidazole-5-yl) methyl-2-quinolinone derivatives as inhibitors of smooth muscle cell proliferation |
| CN1219780C (en) | 1999-03-24 | 2005-09-21 | 阿诺麦德股份有限公司 | Heterocyclic compounds binding chemotactic factor receptor |
| TR200300322T2 (en) * | 2000-09-15 | 2003-09-22 | Anormed Inc. | Heterocyclic compounds that bind the chemokine receptor |
| NZ524651A (en) * | 2000-09-15 | 2005-08-26 | Anormed Inc | Chemokine receptor binding heterocyclic compounds for the treatment of HIV or FIV |
| CZ10903U1 (en) * | 2001-01-11 | 2001-02-19 | Oldrich Ing Cihak | Bladed water wheel |
| AU2002357379A1 (en) * | 2001-12-21 | 2003-07-15 | Anormed Inc. | Chemokine receptor binding heterocyclic compounds with enhanced efficacy |
| US7354932B2 (en) * | 2001-12-21 | 2008-04-08 | Anormed, Inc. | Chemokine receptor binding heterocyclic compounds with enhanced efficacy |
-
2005
- 2005-03-11 RU RU2006136381/04A patent/RU2006136381A/en not_active Application Discontinuation
- 2005-03-11 BR BRPI0508703A patent/BRPI0508703B8/en active IP Right Grant
- 2005-03-11 US US11/077,896 patent/US7332605B2/en active Active
- 2005-03-11 WO PCT/US2005/008268 patent/WO2005090308A1/en active Application Filing
- 2005-03-11 EP EP05725450.0A patent/EP1730113B1/en active Active
- 2005-03-11 CA CA2558389A patent/CA2558389C/en active Active
- 2005-03-11 ES ES05725450.0T patent/ES2614508T3/en active Active
- 2005-03-11 AU AU2005224079A patent/AU2005224079A1/en not_active Abandoned
- 2005-03-11 KR KR1020067019097A patent/KR20060131899A/en not_active Application Discontinuation
- 2005-03-11 CN CN2005800069769A patent/CN1930127B/en active Active
- 2005-03-11 JP JP2007503981A patent/JP4870660B2/en active Active
-
2006
- 2006-08-16 IL IL177511A patent/IL177511A/en active IP Right Grant
- 2006-09-15 NO NO20064200A patent/NO20064200L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| KR20060131899A (en) | 2006-12-20 |
| US7332605B2 (en) | 2008-02-19 |
| BRPI0508703B8 (en) | 2021-05-25 |
| BRPI0508703B1 (en) | 2020-11-24 |
| CA2558389C (en) | 2013-10-08 |
| US20050209277A1 (en) | 2005-09-22 |
| RU2006136381A (en) | 2008-04-27 |
| CN1930127B (en) | 2012-11-21 |
| JP2007529526A (en) | 2007-10-25 |
| EP1730113B1 (en) | 2016-12-28 |
| EP1730113A1 (en) | 2006-12-13 |
| AU2005224079A1 (en) | 2005-09-29 |
| EP1730113A4 (en) | 2009-12-02 |
| ES2614508T3 (en) | 2017-05-31 |
| WO2005090308A1 (en) | 2005-09-29 |
| IL177511A (en) | 2010-12-30 |
| JP4870660B2 (en) | 2012-02-08 |
| NO20064200L (en) | 2006-09-15 |
| CN1930127A (en) | 2007-03-14 |
| BRPI0508703A (en) | 2007-08-07 |
| CA2558389A1 (en) | 2005-09-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed |