IL165933A - Method and packaging for pressurized containers - Google Patents

Method and packaging for pressurized containers

Info

Publication number
IL165933A
IL165933A IL165933A IL16593304A IL165933A IL 165933 A IL165933 A IL 165933A IL 165933 A IL165933 A IL 165933A IL 16593304 A IL16593304 A IL 16593304A IL 165933 A IL165933 A IL 165933A
Authority
IL
Israel
Prior art keywords
hfa
package
adsorbent
pharmaceutical product
permeability
Prior art date
Application number
IL165933A
Other versions
IL165933A0 (en
Original Assignee
Aventis Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Ltd filed Critical Aventis Pharma Ltd
Publication of IL165933A0 publication Critical patent/IL165933A0/en
Publication of IL165933A publication Critical patent/IL165933A/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/18—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents providing specific environment for contents, e.g. temperature above or below ambient
    • B65D81/20—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents providing specific environment for contents, e.g. temperature above or below ambient under vacuum or superatmospheric pressure, or in a special atmosphere, e.g. of inert gas
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/24—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants
    • B65D81/26—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators
    • B65D81/266—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators for absorbing gases, e.g. oxygen absorbers or desiccants
    • B65D81/268—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators for absorbing gases, e.g. oxygen absorbers or desiccants the absorber being enclosed in a small pack, e.g. bag, included in the package
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D1/00—Containers having bodies formed in one piece, e.g. by casting metallic material, by moulding plastics, by blowing vitreous material, by throwing ceramic material, by moulding pulped fibrous material, by deep-drawing operations performed on sheet material
    • B65D1/09—Ampoules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/26—Articles or materials wholly enclosed in laminated sheets or wrapper blanks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/24—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants
    • B65D81/26—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/062—Desiccants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2209/00—Ancillary equipment
    • A61M2209/06—Packaging for specific medical equipment

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Food Science & Technology (AREA)
  • Ceramic Engineering (AREA)
  • Packages (AREA)
  • Wrappers (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Vacuum Packaging (AREA)
  • Auxiliary Devices For And Details Of Packaging Control (AREA)
  • Medicinal Preparation (AREA)
  • Basic Packing Technique (AREA)
  • Laminated Bodies (AREA)

Claims (113)

CLA1 S
1. A method for maintaining the enclosed volume of a sealed package at about ambient pressure, wherein the package contains pressurized MDI (metered dose inhaler) container comprising a drug, and an HFA (hydrofluoroalkane) propeilant selected from the group consisting of HFA 134a and HFA p227, or a mixture thereof; wherein the method comprises the steps of: (i) positioning an effective amount of a HFA adsorbent material, and said pressurized container, within a scalable package; (ii) sealing the package so that the pressurized container and adsorbent are in an enclosed volume within the package at a pressure equal to about ambient pressure; and (iii) adsorbing any leakage of the HFA propeilant into the HFA adsorbent material so as to maintain the enclosed volume at about ambient pressure.
2. The method according to claim 1, wherein the drug is selected from the group consisting of bronchodilators, antihistamines, lung surfactants, antiviral agents, corticosteroids, ant-inflammatory agents, anti-cholinergics, and antibiotic.
3. The method according to claim 1 or 2, wherein the pressurized MDI (metered dose inhaler) container further comprises one or more excipients selected from the group consisting of surfactants, preservatives, flavorings, antioxidants, anti-aggregating agents and co-solvents.
4. The method according to any one of claims 1 to 3, wherein the HFA propeilant is HFA 134a.
5. The method according to any one of claims 1 to 3, wherein the HFA propeilant is HFA p227.
6. The method according to any one of claims 1 to 5, wherein the HFA adsorbent material is capable of adsorbing the HFA propeilant up to about 25% of the weight of the adsorbent.
7. The method according to any one of claims 1 to 5, wherein the HFA gas adsorbent material is capable of adsorbing the HFA propellant up to about 20% of the weight of the adsorbent.
8. The method according to any one of claims 1 to 7, wherein the HFA adsorbent material comprises material selected from the group consisting of molecular sieves, activated clays, activated alumina, silica, zeolites, bauxites, and mixtures thereof.
9. The method according to claim 8, wherein the HFA adsorbent material is 10 A (Angstrom) molecular sieves.
10. The method according to claim 9, wherein the molecular sieves, in an amount of about 4 grams, absorbs about 230 ml of HFA p227.
11. The method according to claim 9, wherein the molecular sieves, in an amount of about 4 grams, absorbs about 230 ml of HFA 134a.
12. The method according to any one of claims 1 to 11, wherein the package is impermeable to HFA 134a.
13. The method according to any one of claims 1 to 12, wherein the package is impermeable to HFA p227.
14. The method according to any one of claims 1 to 12, wherein the package is permeable to HFA p227.
15. The method according to. claim 14, wherein the package has a permeability to HFA p227 that is less than or equal to about 0.25 cc of HFA p227 per square meter of package per day at about 1 bar pressure and about room temperature.
16. The method according to claim 14, wherein the package has a permeability to HFA p227 that is less than or equal to about 0. 5 cc of HFA p227 per square meter of package per day at about 1 bar pressure and about room temperature.
17. The method according to claim 14, wherein the package has a permeability to HFA p227 that is less than or equal to about 0.10 cc of HFA p227 per square meter of package per day at about 1 bar pressure and about room temperature.
18. The method according to claim 14, wherein the package has a permeability to HFA p227 that is less than or equal to about 0.05 cc of HFA p227 per square meter of package per day at about 1 bar pressure and about room temperature.
19. The method according to any one of claims 1 to 11 or 14, wherein the package is permeable to HFA 134a.
20. The method according to claim 19, wherein the package has a permeability to HFA 134a that is less than or equal to about 4.1 cc of HFA 134a per square meter of package per day at about 1 bar pressure and about room temperature.
21. The method according to claim 19, wherein the package has a permeability to HFA 134a that is less than or equal to about 3.5 cc of HFA 134a per square meter of package per day at about 1 bar pressure and about room temperature.
22. The method according to claim 19, wherein the package has a permeability to HFA 134a that is less than or equal to about 2.5 cc of HFA 134a per square meter of package per day at about 1 bar pressure and about room temperature.
23. The method according to claim 19, wherein the package has a permeability to HFA 134a that is less than or equal to about 1.5 cc of HFA 134a per square meter of package per day at about 1 bar pressure and about room temperature.
24.The method according to claim 19, wherein the package has a permeability to HFA 134a that is less than or equal to about 1.0 cc of HFA 134a per square meter of package per day at about 1 bar pressure and about room temperature.
25. The method according to claim 19, wherein the package has a permeability to HFA 134a that is less than or equal to about 0.5 cc of HFA 134a per square meter of package per day at about 1 bar pressure and about room temperature.
26. The method according to any one of claims 1 to 25, wherein the package is made of metal, glass, or plastic, and is selected from the group consisting of bottles, bags, drum boxes, and irregularly shaped containers.
27. The method according to any one of claims 1 to 26, wherein the package is made of plastic.
28. The method according to claim 27, wherein the plastic is a flexible laminate having a barrier layer providing said package with permeability to HFA 134a and/or HFA p227.
29. The method according to claim 27, wherein the plastic is a flexible laminate having a barrier layer providing said package with impermeability to HFA 134a and/or HFA p227. 165933/2 -34-
30. The method according to claim 28 or 29, wherein said flexible laminate has three layers: polyester / aluminum / polyethylene, wherein the aluminum layer is between the polyester and polyethylene layers.
31. The method according to claim 28 or 29, wherein said barrier layer is made of s aluminum foil.
32. The method according to any one of claims 1 to 31, wherein the sealed package is hermetically sealed by heat-sealing, gluing, welding, brazing, mechanical closures or clamps, or compression.
33. An HFA adsorbent for use in maintaining the pressure of an enclosed volume within a 0 sealed package at about ambient pressure, wherein the sealed package comprises: (i) a pressurized MDI (metered dose inhaler) container comprising a drug, a HFA (hydrofluoroalkane) propellant selected from the group consisting of HFA 134a and HFA p227, or a mixture thereof; (ii) an effective amount of an HFA adsorbent material; s wherein the pressurized MDI container and HFA adsorbent material are within the enclosed volume of the sealed package.
34. An HFA adsorbent for use according to claim 33, wherein the drug is selected from the group consisting of bronchodilators, antihistamines, lung surfactants, antiviral agents corticosteroids, ant-inflammatory agents, anti-cholinergics, and antibiotics. 0
35.An HFA adsorbent for use according to claim 33 or 34, wherein the pressurized MDI (metered dose inhaler) container further comprises one or more excipients selected from the group consisting of surfactants, preservatives, flavorings, antioxidants, anti-aggregating agents and co-solvents.
36. An HFA adsorbent for use according to any one of claims 33 to 35, wherein the HFA 5 propellant is HFA 134a.
37. An HFA adsorbent for use according to any one of claims 33 to 35, wherein the HFA propellant is HFA p227.
38. An HFA adsorbent for use according to any one of claims 33 to 37, wherein the HFA adsorbent material is capable of adsorbing the HFA propellant up to about 25% of the weight of 0 the adsorbent. 165933/2 -35-
39. An HFA adsorbent for use according to any one of claims 33 to 37, wherein the HFA gas adsorbent material is capable of adsorbing the HFA propellant up to about 20% of the weight of the adsorbent.
40. An HFA adsorbent for use according to any one of claims 33 to 39, wherein the HFA adsorbent s material comprises material selected from the group consisting of molecular sieves, activated clays, activated alumina, silica, zeolites, bauxites, and mixtures thereof.
41. An HFA adsorbent for use according to claim 40, wherein the HFA adsorbent material is 10 A (Angstrom) molecular sieves.
42. An HFA adsorbent for use according to claim 41 , wherein the molecular sieves, in an amount 0 of about 4 grams, absorbes about 230 ml of HFA p227.
43. An HFA adsorbent for use according to claim 41 , wherein the molecular sieves, in an amount of about 4 grams, absorbes about 230 ml of HFA 134a.
44. An HFA adsorbent for use according to any one of claims 33 to 43, wherein the package is impermeable to HFA 134a. 5
45.An HFA adsorbent for use according to any one of claims 33 to 44, wherein the package is impermeable to HFA p227.
46. An HFA adsorbent for use according to any one of claims 33 to 44, wherein the package is permeable to HFA p227.
47. An HFA adsorbent for use according to claim 46, wherein the package has a permeability to 0 HFA p227 that is less than or equal to about 0.25 cc of HFA p227 per square meter of package per day at about 1 bar pressure and about room temperature.
48. An HFA adsorbent for use according to claim 46, wherein the package has a permeability to HFA p227 that is less than or equal to about 0.15 cc of HFA p227 per square meter of package per day at about 1 bar pressure and about room temperature. 5
49.An HFA adsorbent for use according to claim 46, wherein the package has a permeability to HFA p227 that is less than or equal to about 0.10 cc of HFA p227 per square meter of package per day at about 1 bar pressure and about room temperature.
50.An HFA adsorbent for use according to claim 46, wherein the package has a permeability to HFA p227 that is less than or equal to about 0.05 cc of HFA p227 per square meter of package 0 per day at about 1 bar pressure and about room temperature. 165933/2 -36-
51. An HFA adsorbent for use according to anyone of claims 33 to 43, wherein the package is permeable to HFA 134a.
52. An HFA adsorbent for use according to claim 51 , wherein the package has a permeability to HFA 134a that is less than or equal to about 4.1 cc of HFA 134a per square meter of package s per day at about 1 bar pressure and about room temperature.
53. An HFA adsorbent for use according to claim 51 , wherein the package has a permeability to HFA 134a that is less than or equal to about 3.5 cc of HFA 134a per square meter of package per day at about 1 bar pressure and about room temperature.
54. An HFA adsorbent for use according to claim 51 , wherein the package has a permeability to 0 HFA 134a that is less than or equal to about 2.5 cc of HFA 134a per square meter of package per day at about 1 bar pressure and about room temperature.
55. An HFA adsorbent for use according to claim 51 , wherein the package has a permeability to HFA 134a that is less than or equal to about 1.5 cc of HFA 134a per square meter of package per day at about 1 bar pressure and about room temperature. 5
56. An HFA adsorbent for use according to claim 51 , wherein the package has a permeability to HFA 134a that is less than or equal to about 1.0 cc of HFA 134a per square meter of package per day at about 1 bar pressure and about room temperature.
57. An HFA adsorbent for use according to claim 51 , wherein the package has a permeability to HFA 134a that is less than or equal to about 0.5 cc of HFA 134a per square meter of package 0 per day at about 1 bar pressure and about room temperature.
58. An HFA adsorbent for use according to any one of claims 33 to 57, wherein the package is made of metal, glass, or plastic, and is selected from the group consisting of bottles, bags drum boxes, and irregularly shaped containers.
59. An HFA adsorbent for use according to claim 58, wherein the package is made of plastic. 5
60. An HFA adsorbent for use according to claim 59, wherein the plastic is a flexible laminate having a barrier layer providing said package with impermeability to HFA 134a and/or HFA p227.
61. An HFA adsorbent for use according to claim 59 or 60, wherein the plastic is a flexible laminate having a barrier layer providing said package with permeability to HFA 134a and/or 0 HFA p227. 165933/2 -37-
62. An HFA adsorbent for use according to claim 60 or 61 , wherein said flexible laminate has three layers: polyester / aluminum / polyethylene, wherein the aluminum layer is between the polyester and polyethylene layers.
63. An HFA adsorbent for use according to claim 60 or 61 , wherein said barrier layer is made of s aluminum foil.
64. An HFA adsorbent for use according to any one of claims 33 to 63 wherein the sealed package is hermetically sealed by heat-sealing, gluing, welding, brazing, mechanical closures or clamps, or compression.
65. A pharmaceutical product comprising: 0 (i) a pressurized MDI (metered dose inhaler) container comprising a drug, and an HFA (hydrofluoroalkane) propellent selected from the group consisting of HFA 134a and HFA p227, or a mixture thereof; (ii) an effective amount of an HFA adsorbent material; and (iii) a sealed package having an enclosed volume within which the pressurized s container and the HFA adsorbent material are situated, wherein the sealed package is impermeable to the HFA propellant and the pressure within the enclosed volume of the package is equal to about ambient pressure; and wherein the HFA adsorbent material is capable of adsorbing the HFA propellant 0 so as to maintain a constant pressure within said enclosed volume, when any leakage of the HFA propellant occurs from the pressurized container.
66. The pharmaceutical product according to claim 65, wherein the drug is selected from the group consisting of bronchodilators, antihistamines, lung surfactants, antiviral agents, corticosteroids, ant-inflammatory agents, anti-cholinergics, and antibiotics. 5
67. The pharmaceutical product according to claim 65 or 66, wherein the pressurized MDI (metered dose inhaler) container further comprises one or more excipients selected from the group consisting of surfactants, preservatives, flavorings, antioxidants, anti-aggregating agents and co-solvents.
68. The pharmaceutical product according to any one of claims 65 to 67, wherein the 0 HFA propellant is HFA 134a.
69. The pharmaceutical product according to any one of claims 65 to 67, wherein the HFA propellant is HFA p227.
70. The pharmaceutical product according to any one of claims 65 to 69, wherein the HFA adsorbent material is capable of adsorbing the HFA propellant up to about 25% of the weight of the adsorbent.
71. The pharmaceutical product according to any one of claims 65 to 69, wherein the HFA gas adsorbent material is capable of adsorbing the HFA propellant up about 20% of the weight of the adsorbent.
72. The pharmaceutical product according to any one of claims 65 to 71 , wherein the HFA adsorbent material comprises material selected from the group consisting of molecular sieves, activated clays, activated alumina, silica, zeolites, bauxites, and mixtures thereof.
73. The pharmaceutical product according to claim 72, wherein the HFA adsorbent material is 10 A (Angstrom) molecular sieves.
74. The pharmaceutical product according to claim 73, wherein the molecular sieves, in an amount of about 4 grams, absorbs about 230 ml of HFA p227.
75. The pharmaceutical product according to claim 73, wherein the molecular sieves, in an amount of about 4 grams, absorbs about 230 ml of HFA 134a.
76. The pharmaceutical product according to any one of claims 65 to 75, wherein the package is impermeable to HFA 134a.
77. The pharmaceutical product according to any one of claims 65 to 76, wherein the package is impermeable to HFA p227.
78. The pharmaceutical product according to any one of claims 65 to 77, wherein the package is made of metal, glass, or plastic, and is selected from the group consisting of bottles, bags, drum boxes, and irregularly shaped containers.
79. The pharmaceutical product according to claim 78, wherein the package is made of plastic.
80. The pharmaceutical product according to claim 79, wherein the plastic is a flexible laminate having a barrier layer providing said package with impermeability to HFA 134a and/or HFA p227.
81. The pharmaceutical product according to claim 80, wherein said flexible laminate has three layers: polyester / aluminum / polyethylene, wherein the aluminum layer is between the polyester and polyethylene layers.
82. The pharmaceutical product according to claim 80, wherein said barrier layer is made of aluminum foil.
83. The pharmaceutical product according to any one of claims 65 to 82, wherein the sealed package is hermetically sealed by heat-sealing, gluing, welding, brazing, mechanical closures or clamps, or compression.
84. A pharmaceutical product comprising: (i) a pressurized MDI (metered dose inhaler) container comprising a drug, and an HFA (hydrofluoroalkane) propellant selected from the group consisting of HFA 134a and HFA p227, or a mixture thereof; (ii) an effective amount of an HFA adsorbent material; and (iii) a sealed package having an enclosed volume within which the pressurized container and the HFA adsorbent material are situated, wherein the pressure within the enclosed volume of the package is equal to about ambient pressure; wherein the HFA adsorbent material is capable of adsorbing the HFA propellant so as to maintain a constant pressure within said enclosed volume, when any leakage of the HFA propellant occurs from the pressurized container; and wherein the package has a permeability to HFA p227 that is less than or equal to about 0.25 cc of HFA p227 per square meter of package per day at about 1 bar pressure and about room temperature, or a permeability to HFA 134a that is less than or equal to about 4.1 cc of HFA 134a per square meter of package per day at about 1 bar pressure and about room temperature.
85. A pharmaceutical product according to claim 84, wherein the package has a permeability to HFA p227 that is less than or equal to about 0.15 cc of HFA p227 per square meter of package per day at about 1 bar pressure and about room temperature.
86. A pharmaceutical product according to claim 84, wherein the package has a permeability to HFA p227 that is less than or equal to about 0.10 cc of HFA p227 per square meter of package per day at about 1 bar pressure and about room temperature.
87. A pharmaceutical product according to claim 84, wherein the package has a permeability to HFA p227 that is less than or equal to about 0.05 cc of HFA p227 per square meter of package per day at about 1 bar pressure and about room temperature.
88. A pharmaceutical product according to claim 84, wherein the package has a permeability to HFA 134a that is less than or equal to about 3.5 cc of HFA 134a per square meter of package per day at about 1 bar pressure and about room temperature.
89. A pharmaceutical product according to claim 84, wherein the package has a permeability to HFA 134a that is less than or equal to about 2.5 cc of HFA 134a per square meter of package per day at about 1 bar pressure and about room temperature.
90. A pharmaceutical product according to claim 84, wherein the package has a permeability to HFA 34a that is less than or equal to about 1.5 cc of HFA 134a per square meter of package per day at about 1 bar pressure and about room temperature.
91. A pharmaceutical product according to claim 84, wherein the package has a permeability to HFA 134a that is less than or equal to about 1.0 cc of HFA 134a per square meter of package per day at about 1 bar pressure and about room temperature.
92. A pharmaceutical product according to claim 84, wherein the package has a permeability to HFA 134a that is less than or equal to about 0.5 cc of HFA 134a per square meter of package per day at about 1 bar pressure and about room temperature.
93. A pharmaceutical product according to any one of claims 84 to 92, wherein the drug is selected from the group consisting of bronchodilators, antihistamines, lung surfactants, antiviral agents, corticosteroids, ant-inflammatory agents, anti- cholinergics, and antibiotics.
94. A pharmaceutical product according to any one of claims 84 to 93, wherein the pressurized DI (metered dose inhaler) container further comprises one or more excipients selected from the group consisting of surfactants, preservatives, flavorings, antioxidants, anti-aggregating agents and co-solvents.
95. A pharmaceutical product according to any one of claims 84 to 94, wherein the HFA propellant is HFA 134a.
96. A pharmaceutical product according to any one of claims 84 to 94, wherein the HFA propellant is HFA p227.
97. A pharmaceutical product according to any one of claims 84 to 96, wherein the HFA adsorbent material is capable of adsorbing the HFA propellant up to about 25% of the weight of the adsorbent.
98. A pharmaceutical product according to any one of claims 84 to 96, wherein the HFA gas adsorbent material is capable of adsorbing the HFA propellant up to about 20% of the weight of the adsorbent.
99. A pharmaceutical product according to any one of claims 84 to 98, wherein the HFA adsorbent material comprises material selected from the group consisting of molecular sieves, activated clays, activated alumina, silica, zeolites, bauxites, and mixtures thereof.
100. A pharmaceutical product according to claim 99, wherein the HFA adsorbent material is 10 A (Angstrom) molecular sieves.
101. A pharmaceutical product according to claim 100, wherein the molecular sieves, in an amount of about 4 grams, absorbs about 230 ml of HFA p227.
102. A pharmaceutical product according to claim 100, wherein the molecular sieves, in an amount of about 4 grams, absorbs about 230 ml of HFA 134a.
103. A pharmaceutical product according to claim 84 to 02, wherein the package is made of metal, glass, or plastic, and is selected from the group consisting of bottles, bags, drum boxes, and irregularly shaped containers.
104. A pharmaceutical product according to claim 103, wherein the package is made of plastic.
105. A pharmaceutical product according to claim 104, wherein the plastic is a flexible laminate having a barrier layer providing said package with permeability to HFA 134a and/or HFA p227.
106. A pharmaceutical product according to claim 105, wherein said flexible laminate has three layers: polyester / aluminum / polyethylene, wherein the aluminum layer is between the polyester and polyethylene layers.
107. A pharmaceutical product according to claim 105, wherein said barrier layer is made of aluminum foil.
108. A pharmaceutical product according to any one of claims 84 to 107, wherein the sealed package is hermetically sealed by heat-sealing, gluing, welding, brazing, mechanical closures or clamps, or compression. 165933/2 -43-
109. The method according to any one of claims 1-32 substantially as described hereinabove.
110. The method according to any one of claims 1-32 substantially as illustrated in any of the drawings.
111. An HFA adsorbent for use according to any one of claims 33-64, substantially as described hereinabove.
112. An HFA adsorbent for use according to any one of claims 33-64, substantially as illustrated in any of the drawings.
113. The pharmaceutical product according to any one of claims 65-108 substantially as described hereinabove. 1 14. The pharmaceutical product according to any one of claims 65-108 substantially as illustrated in any of the drawings.
IL165933A 2002-06-26 2004-12-22 Method and packaging for pressurized containers IL165933A (en)

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GBGB0214667.8A GB0214667D0 (en) 2002-06-26 2002-06-26 Method and packaging for pressurized containers
PCT/GB2003/002558 WO2004002559A1 (en) 2002-06-26 2003-06-13 Method and packaging for pressurized containers

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IL165933A0 IL165933A0 (en) 2006-01-15
IL165933A true IL165933A (en) 2010-04-15

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KR (1) KR100995184B1 (en)
CN (1) CN1665559B (en)
AR (1) AR039720A1 (en)
AU (1) AU2003250362B2 (en)
BR (1) BR0312028A (en)
CA (1) CA2490018C (en)
GB (1) GB0214667D0 (en)
HR (1) HRP20041210A2 (en)
IL (1) IL165933A (en)
MX (1) MXPA04012625A (en)
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PA (1) PA8576401A1 (en)
PE (1) PE20040088A1 (en)
RU (1) RU2005101759A (en)
TW (1) TW200406236A (en)
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BRPI0507714B8 (en) 2004-02-16 2021-07-27 Glaxo Group Ltd dose counter for use with a medication dispenser, and, medication dispenser
DE102006009599A1 (en) * 2005-10-28 2007-05-03 Boehringer Ingelheim Pharma Gmbh & Co. Kg Propellant gas absorption with MDIs with packaging
CN102970959B (en) * 2012-03-01 2014-07-30 共同印刷株式会社 Medicine packaging

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US6119853A (en) * 1998-12-18 2000-09-19 Glaxo Wellcome Inc. Method and package for storing a pressurized container containing a drug
US6390291B1 (en) * 1998-12-18 2002-05-21 Smithkline Beecham Corporation Method and package for storing a pressurized container containing a drug
US6352152B1 (en) * 1998-12-18 2002-03-05 Smithkline Beecham Corporation Method and package for storing a pressurized container containing a drug
DE19957439A1 (en) 1999-11-29 2001-06-13 Ticona Gmbh Absorption of formaldehyde in closed, gas impermeable containers
GB2390645A (en) * 2002-05-22 2004-01-14 Cambridge Consultants Drug delivery assembly

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CA2490018C (en) 2011-04-26
JP2005530574A (en) 2005-10-13
CN1665559B (en) 2010-11-03
JP4468169B2 (en) 2010-05-26
EP1515766A1 (en) 2005-03-23
NO20050399L (en) 2005-01-25
PA8576401A1 (en) 2004-02-07
TW200406236A (en) 2004-05-01
AU2003250362B2 (en) 2008-04-24
ZA200409449B (en) 2005-10-14
AU2003250362A1 (en) 2004-01-19
CA2490018A1 (en) 2004-01-08
UY27867A1 (en) 2003-12-31
IL165933A0 (en) 2006-01-15
RU2005101759A (en) 2005-07-10
GB0214667D0 (en) 2002-08-07
MXPA04012625A (en) 2005-03-23
CN1665559A (en) 2005-09-07
BR0312028A (en) 2005-03-22
KR100995184B1 (en) 2010-11-17
KR20050016633A (en) 2005-02-21
PE20040088A1 (en) 2004-04-13
WO2004002559A1 (en) 2004-01-08
AR039720A1 (en) 2005-03-09
HRP20041210A2 (en) 2005-02-28

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