IL164042A0 - Ethane-1,2-diamino-bisÄ2R)-bromo-3-phenylpropanoateÜ, processes for its preparation and its use - Google Patents

Ethane-1,2-diamino-bisÄ2R)-bromo-3-phenylpropanoateÜ, processes for its preparation and its use

Info

Publication number
IL164042A0
IL164042A0 IL16404203A IL16404203A IL164042A0 IL 164042 A0 IL164042 A0 IL 164042A0 IL 16404203 A IL16404203 A IL 16404203A IL 16404203 A IL16404203 A IL 16404203A IL 164042 A0 IL164042 A0 IL 164042A0
Authority
IL
Israel
Prior art keywords
bromo
diamino
ethane
phenylpropanoateü
bisä2r
Prior art date
Application number
IL16404203A
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of IL164042A0 publication Critical patent/IL164042A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/62—Quaternary ammonium compounds
    • C07C211/63—Quaternary ammonium compounds having quaternised nitrogen atoms bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

The invention relates to ethane-1,2-diamino-bis[(2R)-2-bromo-3-phenylpropanoate], the production of ethane-1,2-diamino-bis[(2R)-2-bromo-3-phenylpropanoate] from (2R)-2-bromo-3-phenylpropionic acid and ethylendiamine in 2-propanol and the use of ethane-1,2-diamino-bis[(2R)-2-bromo-3-phenylpropanoate] for the production of ACE/NEP inhibitors.
IL16404203A 2002-03-19 2003-03-07 Ethane-1,2-diamino-bisÄ2R)-bromo-3-phenylpropanoateÜ, processes for its preparation and its use IL164042A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10212198A DE10212198A1 (en) 2002-03-19 2002-03-19 Ethane-1-diaminium-bis (2R) -2-bromo-3-phenylpropanoate), process for its preparation and its use
PCT/EP2003/002353 WO2003078434A1 (en) 2002-03-19 2003-03-07 Ethane-1,2-diamino-bis[(2r)-2-bromo-3-phenylpropanoate], method for production and use thereof

Publications (1)

Publication Number Publication Date
IL164042A0 true IL164042A0 (en) 2005-12-18

Family

ID=27797927

Family Applications (1)

Application Number Title Priority Date Filing Date
IL16404203A IL164042A0 (en) 2002-03-19 2003-03-07 Ethane-1,2-diamino-bisÄ2R)-bromo-3-phenylpropanoateÜ, processes for its preparation and its use

Country Status (10)

Country Link
EP (1) EP1487836B1 (en)
JP (1) JP4532910B2 (en)
AT (1) ATE338756T1 (en)
AU (1) AU2003219027A1 (en)
BR (1) BR0308485A (en)
CA (1) CA2479620A1 (en)
DE (2) DE10212198A1 (en)
IL (1) IL164042A0 (en)
MX (1) MXPA04008490A (en)
WO (1) WO2003078434A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8705591B2 (en) 2007-12-05 2014-04-22 Qualcomm Incorporated Global navigation receiver

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2678759B2 (en) * 1988-02-23 1997-11-17 日本合成化学工業株式会社 Method for producing ammonium salt of solid polymer compound
CA2053340C (en) * 1990-10-18 2002-04-02 Timothy P. Burkholder Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
JPH1014590A (en) * 1996-06-28 1998-01-20 Kanegafuchi Chem Ind Co Ltd Production of optically active 2-substituted-3-phenylpropionic acid and its ester
IT1298267B1 (en) * 1998-02-18 1999-12-20 Zambon Spa PROCEDURE FOR THE PREPARATION OF (S) -2-ACETYLTIO-3-PHENYL-PROPIONIC ACID AND ITS SALTS
NL1014353C2 (en) * 2000-02-11 2001-08-15 Dsm Nv Process for the preparation of (R) -2-bromo-3-phenylpropanoic acid.
NL1014354C2 (en) * 2000-02-11 2001-08-14 Dsm Nv Process for the preparation of (S) -2-acethylthio-3-phenylpropanoic acid.

Also Published As

Publication number Publication date
EP1487836A1 (en) 2004-12-22
AU2003219027A1 (en) 2003-09-29
WO2003078434A1 (en) 2003-09-25
EP1487836B1 (en) 2006-09-06
JP4532910B2 (en) 2010-08-25
BR0308485A (en) 2005-01-18
DE50304950D1 (en) 2006-10-19
DE10212198A1 (en) 2003-10-02
JP2005528358A (en) 2005-09-22
MXPA04008490A (en) 2004-12-06
CA2479620A1 (en) 2003-09-25
ATE338756T1 (en) 2006-09-15

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