IL162276A0 - Nucleic acid molecules as heparanase potent inhibitors, compositions and methods of use thereof - Google Patents
Nucleic acid molecules as heparanase potent inhibitors, compositions and methods of use thereofInfo
- Publication number
- IL162276A0 IL162276A0 IL16227604A IL16227604A IL162276A0 IL 162276 A0 IL162276 A0 IL 162276A0 IL 16227604 A IL16227604 A IL 16227604A IL 16227604 A IL16227604 A IL 16227604A IL 162276 A0 IL162276 A0 IL 162276A0
- Authority
- IL
- Israel
- Prior art keywords
- heparanase
- compositions
- methods
- nucleic acid
- acid molecules
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01166—Heparanase (3.2.1.166)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/111—Antisense spanning the whole gene, or a large part of it
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
- C12N2310/121—Hammerhead
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL16227604A IL162276A0 (en) | 2004-06-01 | 2004-06-01 | Nucleic acid molecules as heparanase potent inhibitors, compositions and methods of use thereof |
US11/569,794 US20070212330A1 (en) | 2004-06-01 | 2005-06-01 | Nucleic Acid Molecules As Herpanase Potent Inhibitors, Compositions And Methods Of Use Thereof |
PCT/IL2005/000570 WO2005118808A1 (fr) | 2004-06-01 | 2005-06-01 | Molecules d'acide nucleique servant d'inhibiteurs puissants d'heparanase, leurs compositions et leurs methodes d'utilisation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL16227604A IL162276A0 (en) | 2004-06-01 | 2004-06-01 | Nucleic acid molecules as heparanase potent inhibitors, compositions and methods of use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
IL162276A0 true IL162276A0 (en) | 2005-11-20 |
Family
ID=35106883
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL16227604A IL162276A0 (en) | 2004-06-01 | 2004-06-01 | Nucleic acid molecules as heparanase potent inhibitors, compositions and methods of use thereof |
Country Status (3)
Country | Link |
---|---|
US (1) | US20070212330A1 (fr) |
IL (1) | IL162276A0 (fr) |
WO (1) | WO2005118808A1 (fr) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7825099B2 (en) * | 2006-01-20 | 2010-11-02 | Quark Pharmaceuticals, Inc. | Treatment or prevention of oto-pathologies by inhibition of pro-apoptotic genes |
EP2170403B1 (fr) * | 2007-06-27 | 2014-04-16 | Quark Pharmaceuticals, Inc. | Compositions et procédés d'inhibition de l'expression de gènes pro-apoptotiques |
US20090247425A1 (en) * | 2008-03-28 | 2009-10-01 | Invitrogen Corporation | Compositions and methods for reusing arrays |
US9428586B2 (en) | 2009-12-01 | 2016-08-30 | Compugen Ltd | Heparanase splice variant |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4458066A (en) * | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
US4415732A (en) * | 1981-03-27 | 1983-11-15 | University Patents, Inc. | Phosphoramidite compounds and processes |
US5885970A (en) * | 1992-03-16 | 1999-03-23 | Isis Pharmaceuticals, Inc. | Antisense oligonucleotides against human protein kinase C |
US5985558A (en) * | 1997-04-14 | 1999-11-16 | Isis Pharmaceuticals Inc. | Antisense oligonucleotide compositions and methods for the inibition of c-Jun and c-Fos |
US5889136A (en) * | 1995-06-09 | 1999-03-30 | The Regents Of The University Of Colorado | Orthoester protecting groups in RNA synthesis |
US6177545B1 (en) * | 1997-09-02 | 2001-01-23 | Insight Strategy & Marketing Ltd. | Heparanase specific molecular probes and their use in research and medical applications |
CA2307830A1 (fr) * | 1997-10-28 | 1999-05-06 | The Australian National University | Molecule isolee d'acide nucleique codant une endoglucuronidase mammalienne et ses applications |
EP1157118A4 (fr) * | 1999-03-01 | 2002-07-17 | Insight Strategy & Marketing | Polynucleotide codant pour un polypeptide ayant une activite d'heparanase et expression de ce polynucleotide dans des cellules genetiquement modifiees |
MXPA01011708A (es) * | 1999-06-25 | 2003-09-10 | Insight Strategy & Marketing | Polinucleotidos que codifican polipeptidos distantemente homologos a heparanasa. |
AU5033101A (en) * | 2000-02-24 | 2001-10-08 | Bayer Aktiengesellschaft | Regulation of human heparanase-like enzyme |
US20050282188A1 (en) * | 2001-05-18 | 2005-12-22 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA) |
US6770753B2 (en) * | 2001-07-05 | 2004-08-03 | The Trustees Of Columbia University In The City Of New York | Phosphorothioate antisense heparanase oligonucleotides |
IL150721A0 (en) * | 2002-07-11 | 2003-02-12 | Hadasit Med Res Service | Method and compositions for regulating mammalian hair growth |
KR20050083855A (ko) * | 2002-11-01 | 2005-08-26 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | HIF-1 알파의 siRNA 억제를 위한 조성물 및 방법 |
US20050164970A1 (en) * | 2003-12-22 | 2005-07-28 | University Of Kansas Medical Center | Method for treating prostate cancer using siRNA duplex for androgen receptor |
-
2004
- 2004-06-01 IL IL16227604A patent/IL162276A0/xx unknown
-
2005
- 2005-06-01 US US11/569,794 patent/US20070212330A1/en not_active Abandoned
- 2005-06-01 WO PCT/IL2005/000570 patent/WO2005118808A1/fr active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO2005118808A1 (fr) | 2005-12-15 |
US20070212330A1 (en) | 2007-09-13 |
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