IL162069A0 - Gabusectin derivatives, processes for preparing them and their use - Google Patents

Gabusectin derivatives, processes for preparing them and their use

Info

Publication number
IL162069A0
IL162069A0 IL16206902A IL16206902A IL162069A0 IL 162069 A0 IL162069 A0 IL 162069A0 IL 16206902 A IL16206902 A IL 16206902A IL 16206902 A IL16206902 A IL 16206902A IL 162069 A0 IL162069 A0 IL 162069A0
Authority
IL
Israel
Prior art keywords
derivatives
gabusectin
alkenyl
alkyl
optionally substituted
Prior art date
Application number
IL16206902A
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of IL162069A0 publication Critical patent/IL162069A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

3-(Octahydronaphth-1-yl-methylene)-pyrrolidine derivatives (I) and its derivatives, are new. Gabusectin compounds of formula (I) and their stereoisomers and tautomers (including mixtures in all ratios) and salts are new. R1-R3 = H; or 1-6C alkyl, 2-6C alkenyl or 2-6C alkynyl (all optionally substituted by 1-2 of OH, =O, halo or NH2; or 1-6C alkoxy, 2-6C alkenyloxy, aryl, 1-6C alkylamino or 2-6C alkenylamino (all optionally substituted by CN, amide or oxime functions)); R4 = 1-6C alkyl or 2-6C alkenyl (both optionally substituted as in R1-R3); R5 = H or Me; X1-X5 = O, NH, N-(1-6C alkyl), N-(2-6C alkenyl), N-(2-6C alkynyl), N-acyl, N-aryl, N-O-R1 or S. Independent claims are also included for: (1) the preparation of (I); and (2) the new microorganism ST003236 (DSM 14476).
IL16206902A 2001-11-21 2002-11-07 Gabusectin derivatives, processes for preparing them and their use IL162069A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10156906A DE10156906A1 (en) 2001-11-21 2001-11-21 New 3-(octahydronaphth-1-yl-methylene)-pyrrolidine derivatives, prepared by culturing a microorganism, shows strong antibacterial activity
PCT/EP2002/012420 WO2003043984A1 (en) 2001-11-21 2002-11-07 Gabusectin derivatives, method for the production thereof and use of the same

Publications (1)

Publication Number Publication Date
IL162069A0 true IL162069A0 (en) 2005-11-20

Family

ID=7706333

Family Applications (1)

Application Number Title Priority Date Filing Date
IL16206902A IL162069A0 (en) 2001-11-21 2002-11-07 Gabusectin derivatives, processes for preparing them and their use

Country Status (10)

Country Link
EP (1) EP1448522B1 (en)
JP (1) JP2006501132A (en)
AT (1) ATE421951T1 (en)
AU (1) AU2002366191B2 (en)
CA (1) CA2467251A1 (en)
DE (2) DE10156906A1 (en)
IL (1) IL162069A0 (en)
MX (1) MXPA04004537A (en)
PE (1) PE20030538A1 (en)
WO (1) WO2003043984A1 (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6476062B2 (en) * 2000-03-30 2002-11-05 Schering Corporation Chemokine receptor antagonists
DE10060810A1 (en) * 2000-12-07 2002-06-20 Aventis Pharma Gmbh Coniosetin and derivatives thereof, processes for making and using the same

Also Published As

Publication number Publication date
AU2002366191B2 (en) 2008-01-31
AU2002366191A1 (en) 2003-06-10
WO2003043984A1 (en) 2003-05-30
EP1448522B1 (en) 2009-01-28
EP1448522A1 (en) 2004-08-25
ATE421951T1 (en) 2009-02-15
MXPA04004537A (en) 2004-08-11
DE50213257D1 (en) 2009-03-19
PE20030538A1 (en) 2003-08-01
DE10156906A1 (en) 2003-05-28
CA2467251A1 (en) 2003-05-30
JP2006501132A (en) 2006-01-12

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IL162069A0 (en) Gabusectin derivatives, processes for preparing them and their use