IL160702A0 - Apparatus and method for high-throughput preparation and characterization of composition - Google Patents

Apparatus and method for high-throughput preparation and characterization of composition

Info

Publication number
IL160702A0
IL160702A0 IL16070202A IL16070202A IL160702A0 IL 160702 A0 IL160702 A0 IL 160702A0 IL 16070202 A IL16070202 A IL 16070202A IL 16070202 A IL16070202 A IL 16070202A IL 160702 A0 IL160702 A0 IL 160702A0
Authority
IL
Israel
Prior art keywords
characterization
composition
throughput preparation
throughput
preparation
Prior art date
Application number
IL16070202A
Other languages
English (en)
Original Assignee
Transform Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Transform Pharmaceuticals Inc filed Critical Transform Pharmaceuticals Inc
Publication of IL160702A0 publication Critical patent/IL160702A0/xx

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/028—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having reaction cells in the form of microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082—Test tubes per se
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B29/00—Single crystals or homogeneous polycrystalline material with defined structure characterised by the material or by their shape
    • C30B29/54—Organic compounds
    • C30B29/58—Macromolecular compounds
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
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    • B01J2219/00331—Details of the reactor vessels
    • B01J2219/00333—Closures attached to the reactor vessels
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    • B01J2219/00333—Closures attached to the reactor vessels
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    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
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    • B01J2219/00279—Features relating to reactor vessels
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    • B01J2219/00495—Means for heating or cooling the reaction vessels
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    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B01J2219/00547—Bar codes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • Y10T117/1012—Apparatus with means for measuring, testing, or sensing with a window or port for visual observation or examination
IL16070202A 2001-09-07 2002-09-06 Apparatus and method for high-throughput preparation and characterization of composition IL160702A0 (en)

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Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040252299A9 (en) 2000-01-07 2004-12-16 Lemmo Anthony V. Apparatus and method for high-throughput preparation and spectroscopic classification and characterization of compositions
US20050095696A9 (en) * 2000-01-07 2005-05-05 Lemmo Anthony V. Apparatus and method for high-throughput preparation and characterization of compositions
US20070020662A1 (en) * 2000-01-07 2007-01-25 Transform Pharmaceuticals, Inc. Computerized control of high-throughput experimental processing and digital analysis of comparative samples for a compound of interest
US20070021929A1 (en) * 2000-01-07 2007-01-25 Transform Pharmaceuticals, Inc. Computing methods for control of high-throughput experimental processing, digital analysis, and re-arraying comparative samples in computer-designed arrays
JP4066661B2 (ja) * 2002-01-23 2008-03-26 セイコーエプソン株式会社 有機ｅｌ装置の製造装置および液滴吐出装置
US20050233461A1 (en) * 2002-06-05 2005-10-20 Douglas Levinson High-throughput methods and systems for screening of compounds to treat/prevent kidney disorders
WO2004099787A1 (fr) * 2003-05-05 2004-11-18 Visible Diagnostics A/S Systeme de transport automatique d'echantillons et utilisation de ce systeme
GB0314686D0 (en) * 2003-06-24 2003-07-30 Rts Thurnall Plc Methods and apparatus for handling compound storage vessels
GB0525559D0 (en) * 2005-12-15 2006-01-25 Oxford Diffraction Ltd In-situ crystalline material screening apparatus and method
EP1811287A1 (fr) * 2006-01-20 2007-07-25 Ecole Polytechnique Système Raman polarimétrique et procédé d'analyse d'un échantillon
US8252232B2 (en) 2006-01-23 2012-08-28 Brooks Automation, Inc. Automated system for storing, retrieving and managing sample
US10697987B2 (en) 2006-01-23 2020-06-30 Brooks Automation, Inc. Automated system for storing, retrieving and managing samples
GB2464717B (en) * 2008-10-24 2012-11-28 Bibby Scient Ltd Apparatus for measuring the melting point of a substance
US8891086B2 (en) * 2009-06-15 2014-11-18 Thermo Scientific Portable Analytical Instruments Inc. Optical scanning systems and methods for measuring a sealed container with a layer for reducing diffusive scattering
CN104411700B (zh) 2012-07-25 2016-06-15 株式会社富士药品 4-[5-(吡啶-4-基)-1h-1,2,4-三唑-3-基]吡啶-2-腈的多晶型及其制造方法
US9841360B1 (en) * 2012-10-15 2017-12-12 Michael C. Solazzi Sample cup assembly, system and method for purging
US9488569B2 (en) 2013-06-10 2016-11-08 Florida Agricultural And Mechanical University Method and systems to detect matter through use of a magnetic field gradient
US10309902B2 (en) * 2014-09-28 2019-06-04 Purdue Research Foundation Characterization of trace crystallinity by second harmonic generation microscopy
WO2016141192A1 (fr) 2015-03-04 2016-09-09 Scarlett Carol Y Génération de nombres aléatoires grâce à l'utilisation d'effets d'optique quantique dans un système de cavités à miroirs
US10394525B2 (en) 2015-03-04 2019-08-27 Carol Y. Scarlett Generation of random numbers through the use of quantum-optical effects within a multi-layered birefringent structure
US10705799B2 (en) 2015-03-04 2020-07-07 Carol Y. Scarlett Transmission of information through the use of quantum-optical effects within a multi-layered birefringent structure
US10552936B2 (en) * 2016-03-02 2020-02-04 Alibaba Group Holding Limited Solid state storage local image processing system and method
US20180149584A1 (en) 2016-11-29 2018-05-31 Carol Y. Scarlett Circular birefringence identification of materials
US9820157B1 (en) * 2017-03-06 2017-11-14 Wipro Limited Method and system for localizing spatially separated wireless transmitters
CN107067034B (zh) * 2017-04-15 2020-06-23 温州大学 一种快速识别红外光谱数据分类的方法及系统
US10955429B1 (en) * 2017-12-06 2021-03-23 National Technology & Engineering Solutions Of Sandia, Llc Inspection workcell
US10809199B2 (en) 2018-08-07 2020-10-20 Synaptive Medical (Barbados) Inc. Dynamic raman signal acquisition system, method and apparatus

Family Cites Families (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1598738C3 (de) * 1965-01-05 1974-07-18 Karl-Heinz Dipl.-Phys. 1000 Berlin Meinig Automatischer Probenwechsler zur Messung der Aktivitätskonzentration von flüssigen, in Reagenzgläsern aufgenommenen radioaktiven Proben
US3899011A (en) * 1972-08-18 1975-08-12 Pfizer Disc dispenser
SE380099B (fr) * 1974-02-07 1975-10-27 Monega Anstalt
US4399687A (en) * 1980-12-23 1983-08-23 Carter Collins Apparatus for analyzing and identifying odorants
US4835711A (en) * 1986-05-30 1989-05-30 Zymark Corporation Quickly reconfigurable robotic system
US4877745A (en) * 1986-11-17 1989-10-31 Abbott Laboratories Apparatus and process for reagent fluid dispensing and printing
US5744101A (en) * 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5143854A (en) * 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
EP0517791A1 (fr) * 1990-03-02 1992-12-16 Tekmar Company Dispositif de transport d'analyseur
JPH0678978B2 (ja) * 1990-05-25 1994-10-05 スズキ株式会社 凝集パターン検出装置
US5417923A (en) * 1991-04-24 1995-05-23 Pfizer Inc. Assay tray assembly
EP0581984B1 (fr) * 1992-08-04 1998-02-04 Hewlett-Packard GmbH Appareil de manipulation de flacons dans un automate d'analyse
US5324483B1 (en) * 1992-10-08 1996-09-24 Warner Lambert Co Apparatus for multiple simultaneous synthesis
AU700315B2 (en) * 1993-10-28 1998-12-24 Houston Advanced Research Center Microfabricated, flowthrough porous apparatus for discrete detection of binding reactions
US5807522A (en) * 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US5705333A (en) * 1994-08-05 1998-01-06 The Regents Of The University Of California Peptide-based nucleic acid mimics(PENAMS)
US5463564A (en) * 1994-09-16 1995-10-31 3-Dimensional Pharmaceuticals, Inc. System and method of automatically generating chemical compounds with desired properties
US7166470B2 (en) * 1994-10-18 2007-01-23 Symyx Technologies, Inc. Formation of combinatorial arrays of materials using solution-based methodologies
US5985356A (en) * 1994-10-18 1999-11-16 The Regents Of The University Of California Combinatorial synthesis of novel materials
US5658802A (en) * 1995-09-07 1997-08-19 Microfab Technologies, Inc. Method and apparatus for making miniaturized diagnostic arrays
US5763278A (en) * 1995-11-01 1998-06-09 Tecan Ag Automated pipetting of small volumes
US5832182A (en) * 1996-04-24 1998-11-03 Wisconsin Alumni Research Foundation Method and system for data clustering for very large databases
CA2253587C (fr) * 1996-05-09 2008-01-29 3-Dimensional Pharmaceuticals, Inc. Procede d'analyse et appareil a changement thermique et a microplaque pour l'optimisation de la mise au point de ligands et de la chimie des proteines a variables multiples
GB2313188B (en) * 1996-05-17 1999-10-20 Pfizer Ltd Spectrophotometric analysis
US6175816B1 (en) * 1997-05-23 2001-01-16 Advanced Life Sciences, Inc. Use of automated technology in chemical process research and development
US6003029A (en) * 1997-08-22 1999-12-14 International Business Machines Corporation Automatic subspace clustering of high dimensional data for data mining applications
WO1999012113A1 (fr) * 1997-09-05 1999-03-11 Molecular Simulations Inc. Modelisation d'interactions avec des parametres atomiques y compris une polarisabilite dipolaire anisotropique
GB9719673D0 (en) * 1997-09-17 1997-11-19 Glaxo Group Ltd Novel apparatus
US5999255A (en) * 1997-10-09 1999-12-07 Solutia Inc. Method and apparatus for measuring Raman spectra and physical properties in-situ
US5928952A (en) * 1997-11-05 1999-07-27 Zymark Corporation Scheduled system and method for processing chemical products
US6323132B1 (en) * 1998-01-13 2001-11-27 Applied Materials, Inc. Etching methods for anisotropic platinum profile
US6265226B1 (en) * 1998-04-03 2001-07-24 Symyx Technologies, Inc. Automated sampling methods for rapid characterization of polymers
GB2336935B (en) * 1998-04-30 2002-03-27 Daewoo Electronics Co Ltd Connecting device for use in a head drum assembly
US6100901A (en) * 1998-06-22 2000-08-08 International Business Machines Corporation Method and apparatus for cluster exploration and visualization
US5956137A (en) * 1998-11-05 1999-09-21 Chartered Semiconductor Manufacturing Ltd. In-line process monitoring using micro-raman spectroscopy
US5965137A (en) * 1998-11-16 1999-10-12 Advanced Medical Instruments Insect repellent composition and method for inhibiting the transmission and treatment of symptoms of vector-borne diseases
US6477479B1 (en) * 1998-12-11 2002-11-05 Symyx Technologies Sensor array for rapid materials characterization
WO2000037917A2 (fr) * 1998-12-23 2000-06-29 Medispectra, Inc. Systemes et procedes d'analyse optique d'echantillons
US6140643A (en) * 1999-03-09 2000-10-31 Exxonmobil Upstream Research Company Method for identification of unknown substances
US6487523B2 (en) * 1999-04-07 2002-11-26 Battelle Memorial Institute Model for spectral and chromatographic data
US6296673B1 (en) * 1999-06-18 2001-10-02 The Regents Of The University Of California Methods and apparatus for performing array microcrystallizations
US6327334B1 (en) * 1999-11-18 2001-12-04 Uop Llc Method of rapidly screening X-ray powder diffraction patterns
US20020061599A1 (en) * 1999-12-30 2002-05-23 Elling Christian E. Method of identifying ligands of biological target molecules
US20050095696A9 (en) * 2000-01-07 2005-05-05 Lemmo Anthony V. Apparatus and method for high-throughput preparation and characterization of compositions
US20040252299A9 (en) * 2000-01-07 2004-12-16 Lemmo Anthony V. Apparatus and method for high-throughput preparation and spectroscopic classification and characterization of compositions
US20050089923A9 (en) * 2000-01-07 2005-04-28 Levinson Douglas A. Method and system for planning, performing, and assessing high-throughput screening of multicomponent chemical compositions and solid forms of compounds
JP2003519698A (ja) * 2000-01-07 2003-06-24 トランスフォーム ファーマスーティカルズ，インコーポレイテッド 多様な固体形態のハイスループットでの形成、同定および分析
US20050118637A9 (en) * 2000-01-07 2005-06-02 Levinson Douglas A. Method and system for planning, performing, and assessing high-throughput screening of multicomponent chemical compositions and solid forms of compounds
US7108970B2 (en) * 2000-01-07 2006-09-19 Transform Pharmaceuticals, Inc. Rapid identification of conditions, compounds, or compositions that inhibit, prevent, induce, modify, or reverse transitions of physical state
US6333501B1 (en) * 2000-01-27 2001-12-25 Perkin-Elmer Corporation Methods, apparatus, and articles of manufacture for performing spectral calibration
US6907350B2 (en) * 2000-03-13 2005-06-14 Chugai Seiyaku Kabushiki Kaisha Method, system and apparatus for handling information on chemical substances
GB0008563D0 (en) * 2000-04-07 2000-05-24 Cambridge Discovery Chemistry Investigating different physical and/or chemical forms of materials
US20010036640A1 (en) * 2000-04-25 2001-11-01 D'amico Kevin L. System and methods for the high throughput screening of polymorphs
US6664067B1 (en) * 2000-05-26 2003-12-16 Symyx Technologies, Inc. Instrument for high throughput measurement of material physical properties and method of using same
GB0016459D0 (en) * 2000-07-04 2000-08-23 Pattern Recognition Systems As Method
US20030022234A1 (en) * 2001-05-31 2003-01-30 Cawse James Norman Method and system to conduct a combinatorial high throughput screening experiment
US20030124028A1 (en) * 2001-08-10 2003-07-03 Carlson Eric D. Apparatuses and methods for creating and testing pre-formulations and systems for same

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US20030106492A1 (en) 2003-06-12
WO2003023409A3 (fr) 2003-12-24
WO2003023409A2 (fr) 2003-03-20
EP1428032A2 (fr) 2004-06-16
AU2002336457A1 (en) 2003-03-24

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