IL158228A - Use of esters of long-chain fatty acids for the preparation of medicaments for the treatment of autoimmune diseases - Google Patents

Use of esters of long-chain fatty acids for the preparation of medicaments for the treatment of autoimmune diseases

Info

Publication number
IL158228A
IL158228A IL158228A IL15822803A IL158228A IL 158228 A IL158228 A IL 158228A IL 158228 A IL158228 A IL 158228A IL 15822803 A IL15822803 A IL 15822803A IL 158228 A IL158228 A IL 158228A
Authority
IL
Israel
Prior art keywords
use according
fatty acid
cis
unsaturated
saturated
Prior art date
Application number
IL158228A
Inventor
Pinchas Burstein
Avraham Ben-Nun
Original Assignee
Yeda Res & Dev
Pinchas Burstein
Avraham Ben-Nun
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Res & Dev, Pinchas Burstein, Avraham Ben-Nun filed Critical Yeda Res & Dev
Priority to IL158228A priority Critical patent/IL158228A/en
Publication of IL158228A publication Critical patent/IL158228A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7024—Esters of saccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A61K31/231—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having one or two double bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A61K31/232—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having three or more double bonds, e.g. etretinate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Agents selected from: (i) a C1-C24 alkyl ester of a saturated or cis-unsaturated C10-C24 fatty acid; (ii) a monoester or polyester of a polyol having at least four hydroxy groups with a saturated or cis-unsaturated C10-C24 fatty acid or an anhydro derivative thereof; (iii) a monoester or polyester of a mono-, di- or poly-saccharide with a saturated or cis-unsaturated C10-C24 fatty acid; (iv) an amide of a saturated or cis-unsaturated C10-C24 fatty acid with an aliphatic or aromatic amine or with an amino acid, peptide, protein or aminosaccharide; and (v) combinations of any of (i) to (iv), can be used for treatment of autoimmune diseases and other immune-associated inflammatory disorders. Preferred agents are ethyl oleate and mannide monooleate or a combination thereof.

Claims (7)

158228/2 CLAIMS:
1. Use of an ester of a saturated or cis-unsaturated Q8 fatty acid with a Ci -C24 alkanol, with a polyol having at least four hydroxy groups or an anhydro derivative thereof, or with a monosaccharide, or a combination of said esters, for the preparation of a pharmaceutical composition for the treatment of organ-specific autoimmune diseases.
2. Use according to claim 1 wherein said saturated Cj8 fatty acid is stearic acid and said cis-unsaturated C18 fatty acid is oleic acid.
3. Use according to claim 2 wherein said ester is ethyl oleate.
4. Use according to claim 2 wherein said ester is mannide monooleate.
5. Use according to claim 2 of a mixture of ethyl oleate and mannide monooleate.
6. Use according to claim 5 of a 1 : 1 mixture of ethyl oleate and mannide monooleate.
7. Use according to any one of claims 1 to 6 wherein said organ-specific autoimmune disease is selected from multiple sclerosis (MS), insulin-dependent diabetes mellitus (IDDM), rheumatoid arthritis, thyroiditis, myasthenia gravis, aplastic anemia, hemolytic anemia, autoimmune hepatitis, thyroiditis, iridocyclitis, scleritis, uveitis, orchitis, idiopathic thrombocytopenia purpura, and inflammatory bowel diseases such as Crohn's disease and ulcerative colitis. For the applicant, Ben- Ami & Associates Patent Attorneys
IL158228A 2001-04-11 2003-10-02 Use of esters of long-chain fatty acids for the preparation of medicaments for the treatment of autoimmune diseases IL158228A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IL158228A IL158228A (en) 2001-04-11 2003-10-02 Use of esters of long-chain fatty acids for the preparation of medicaments for the treatment of autoimmune diseases

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IL14253701A IL142537A0 (en) 2001-04-11 2001-04-11 Pharmaceutical compositions for the treatment of autoimmune diseases
PCT/IL2002/000296 WO2002083059A2 (en) 2001-04-11 2002-04-11 Use of esters of long-chain fatty acids for treatment of autoimmune diseases
IL158228A IL158228A (en) 2001-04-11 2003-10-02 Use of esters of long-chain fatty acids for the preparation of medicaments for the treatment of autoimmune diseases

Publications (1)

Publication Number Publication Date
IL158228A true IL158228A (en) 2009-12-24

Family

ID=11075314

Family Applications (2)

Application Number Title Priority Date Filing Date
IL14253701A IL142537A0 (en) 2001-04-11 2001-04-11 Pharmaceutical compositions for the treatment of autoimmune diseases
IL158228A IL158228A (en) 2001-04-11 2003-10-02 Use of esters of long-chain fatty acids for the preparation of medicaments for the treatment of autoimmune diseases

Family Applications Before (1)

Application Number Title Priority Date Filing Date
IL14253701A IL142537A0 (en) 2001-04-11 2001-04-11 Pharmaceutical compositions for the treatment of autoimmune diseases

Country Status (8)

Country Link
US (1) US8614248B2 (en)
EP (1) EP1480595B1 (en)
AT (1) ATE415157T1 (en)
AU (1) AU2002255242A1 (en)
DE (1) DE60230067D1 (en)
ES (1) ES2321166T3 (en)
IL (2) IL142537A0 (en)
WO (1) WO2002083059A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1509618T3 (en) 2002-05-13 2008-12-08 Arexis Ab Autoimmune diseases and NADPH oxidase defects
ITMI20030210A1 (en) * 2003-02-07 2004-08-08 Res & Innovation Soc Coop A R L ENDOCANNABINOID-SIMILAR COMPOUNDS AND THEIR USE
US20050032892A1 (en) * 2003-08-07 2005-02-10 The Procter & Gamble Company Compositions, kits, and methods for treating gastrointestinal conditions
US7294739B1 (en) 2006-11-06 2007-11-13 Teva Pharmacaetical Industries Ltd. Basic amine esters or oleic acid and their use as anti-inflammatory or immunobodulatory agents
CA2713527A1 (en) * 2008-01-28 2009-08-06 Mead Johnson Nutrition Company Nutritional composition containing dha, rumenic acid, and gangliosides
WO2012006612A2 (en) * 2010-07-09 2012-01-12 President And Fellows Of Harvard College Use of trans-palmitoleate in identifying and treating metabolic disease
CN110812486A (en) * 2012-07-09 2020-02-21 华柏恩视觉研究中心 Compositions, methods and/or devices for preventing and/or treating dry eye
FR3011467B1 (en) * 2013-10-08 2016-02-12 Centre Nat Rech Scient COMPOUNDS AND COMPOSITIONS COMPRISING SUCH COMPOUNDS FOR THE PREVENTION OR TREATMENT OF DYSLIPIDEMIA

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2515174A1 (en) * 1981-10-23 1983-04-29 Roussel Uclaf NOVEL TRIGLYCERIDES, PROCESS FOR THE PREPARATION AND APPLICATIONS IN DIETETICS AND THERAPEUTICS
US5231087A (en) * 1988-03-16 1993-07-27 Cellegy Pharmaceuticals, Inc. Treatment of skin diseases and tumors with esters and amides of monocarboxylic acids
JP3558351B2 (en) * 1992-12-07 2004-08-25 邦郎 辻 Immunosuppressants
JPH06345644A (en) * 1993-06-10 1994-12-20 Unitika Ltd Therapeutic agent for autoimmune disease
US5792774A (en) * 1996-02-21 1998-08-11 Chiroscience Limited Quinolones and their therapeutic use
US5683698A (en) * 1996-08-02 1997-11-04 New England Deaconess Hospital Formulation for alleviating symptoms associated with arthritis
WO2001003688A2 (en) * 1999-07-09 2001-01-18 Pharmacia Corporation Treatment of cyclooxygenase-2 mediated disorders using conjugated fatty acid compounds
JP2003507437A (en) * 1999-08-26 2003-02-25 ガネデン バイオテック， インコーポレイテッド Use of emu oil, a carrier for antifungal, antibacterial, and antiviral drugs

Also Published As

Publication number Publication date
ES2321166T3 (en) 2009-06-03
WO2002083059A2 (en) 2002-10-24
US8614248B2 (en) 2013-12-24
EP1480595A4 (en) 2005-05-11
EP1480595A2 (en) 2004-12-01
DE60230067D1 (en) 2009-01-08
AU2002255242A1 (en) 2002-10-28
WO2002083059A3 (en) 2004-10-07
US20040186072A1 (en) 2004-09-23
ATE415157T1 (en) 2008-12-15
EP1480595B1 (en) 2008-11-26
IL142537A0 (en) 2002-03-10

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Legal Events

Date Code Title Description
FF Patent granted
MM9K Patent not in force due to non-payment of renewal fees
NE Application for restoration - patent lapsed through non-payment of renewal fees (section 60, patents law, 5727-1967)
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees