IL156224A0 - Compounds which mimic the chemical and biological properties of discodermolide - Google Patents
Compounds which mimic the chemical and biological properties of discodermolideInfo
- Publication number
- IL156224A0 IL156224A0 IL15622401A IL15622401A IL156224A0 IL 156224 A0 IL156224 A0 IL 156224A0 IL 15622401 A IL15622401 A IL 15622401A IL 15622401 A IL15622401 A IL 15622401A IL 156224 A0 IL156224 A0 IL 156224A0
- Authority
- IL
- Israel
- Prior art keywords
- discodermolide
- mimic
- compounds
- chemical
- biological properties
- Prior art date
Links
- AADVCYNFEREWOS-UHFFFAOYSA-N (+)-DDM Natural products C=CC=CC(C)C(OC(N)=O)C(C)C(O)C(C)CC(C)=CC(C)C(O)C(C)C=CC(O)CC1OC(=O)C(C)C(O)C1C AADVCYNFEREWOS-UHFFFAOYSA-N 0.000 title 1
- AADVCYNFEREWOS-OBRABYBLSA-N Discodermolide Chemical compound C=C\C=C/[C@H](C)[C@H](OC(N)=O)[C@@H](C)[C@H](O)[C@@H](C)C\C(C)=C/[C@H](C)[C@@H](O)[C@@H](C)\C=C/[C@@H](O)C[C@@H]1OC(=O)[C@H](C)[C@@H](O)[C@H]1C AADVCYNFEREWOS-OBRABYBLSA-N 0.000 title 1
- 230000004071 biological effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 230000003278 mimic effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C239/00—Compounds containing nitrogen-to-halogen bonds; Hydroxylamino compounds or ethers or esters thereof
- C07C239/02—Compounds containing nitrogen-to-halogen bonds
- C07C239/06—N-halogenated carboxamides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/12—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/22—Oxygen atoms attached in position 2 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to other ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/16—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by esterified hydroxyl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
- C07D339/08—Six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- C07F7/1872—Preparation; Treatments not provided for in C07F7/20
- C07F7/1892—Preparation; Treatments not provided for in C07F7/20 by reactions not provided for in C07F7/1876 - C07F7/1888
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/730,929 US6870058B2 (en) | 1996-12-03 | 2000-12-06 | Compounds which mimic the chemical and biological properties of discodermolide |
| PCT/US2001/047958 WO2002046150A2 (en) | 2000-12-06 | 2001-12-06 | Compounds which mimic the chemical and biological properties of discodermolide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL156224A0 true IL156224A0 (en) | 2003-12-23 |
Family
ID=24937372
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL15622401A IL156224A0 (en) | 2000-12-06 | 2001-12-06 | Compounds which mimic the chemical and biological properties of discodermolide |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6870058B2 (zh) |
| EP (1) | EP1585725A4 (zh) |
| KR (1) | KR20040062418A (zh) |
| CN (1) | CN101389619A (zh) |
| AU (1) | AU2002227375A1 (zh) |
| CA (1) | CA2431045A1 (zh) |
| IL (1) | IL156224A0 (zh) |
| WO (1) | WO2002046150A2 (zh) |
| ZA (1) | ZA200304259B (zh) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050065353A1 (en) * | 1996-12-03 | 2005-03-24 | Smith Amos B. | Synthetic techniques and intermediates for polyhydroxy dienyl lactones and mimics thereof |
| JP4243183B2 (ja) | 2001-08-06 | 2009-03-25 | ノバルティス アクチエンゲゼルシャフト | 一定の置換ポリケチド、それらを含む医薬組成物および腫瘍処置におけるそれらの使用 |
| WO2003013502A1 (en) | 2001-08-07 | 2003-02-20 | The Trustees Of The University Of Pennsylvania | Compounds which mimic the chemical and biological properties of discodermolide |
| US6833367B2 (en) | 2001-11-16 | 2004-12-21 | Novartis Ac | Certain substituted polyketides, pharmaceutical compositions containing them and their use in treating tumors |
| WO2004101508A2 (en) * | 2003-04-02 | 2004-11-25 | The Trustees Of The University Of Pennsylvania | Synthetic techniques and intermediates for polyhydroxy dienyl lactones and mimics thereof |
| GB0321538D0 (en) * | 2003-09-13 | 2003-10-15 | Glaxo Group Ltd | Therapeutically useful compounds |
| US7348436B2 (en) * | 2004-03-02 | 2008-03-25 | Kosan Biosciences Incorporated | Compounds useful for the synthesis of (+)-discodermolide and methods thereof |
| CA2567984C (en) * | 2004-06-03 | 2014-05-20 | Eisai Co., Ltd. | Intermediates for the preparation of analogs of halichondrin b |
| US7214708B2 (en) * | 2004-11-18 | 2007-05-08 | Kosan Biosciences Incorporated | Synthetic discodermolide analogs |
| CN104311571B (zh) | 2007-10-03 | 2019-07-02 | 卫材R&D管理有限公司 | 用于合成软海绵素b类似物的中间体和方法 |
| AU2011278927B2 (en) | 2010-07-16 | 2015-05-21 | Abbvie Ireland Unlimited Company | Process for preparing antiviral compounds |
| US9255074B2 (en) | 2010-07-16 | 2016-02-09 | Abbvie Inc. | Process for preparing antiviral compounds |
| NZ605471A (en) | 2010-07-16 | 2015-02-27 | Abbvie Bahamas Ltd | Phosphine ligands for catalytic reactions |
| US8975443B2 (en) | 2010-07-16 | 2015-03-10 | Abbvie Inc. | Phosphine ligands for catalytic reactions |
| RU2710545C2 (ru) | 2013-11-04 | 2019-12-27 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Реакции макроциклизации и промежуточные соединения и другие фрагменты, пригодные в получении аналогов халихондрина b |
| US10308661B2 (en) | 2015-05-07 | 2019-06-04 | Eisai R&D Management Co., Ltd. | Macrocyclization reactions and intermediates and other fragments useful in the synthesis of halichondrin macrolides |
| MX2018009794A (es) | 2016-02-12 | 2018-12-17 | Eisai R&D Man Co Ltd | Intermediarios en la sintesis de eribulina y metodos de sintesis relacionados. |
| MX2018016329A (es) | 2016-06-30 | 2019-09-18 | Eisai R&D Man Co Ltd | Reaccion de prins e intermediarios utiles en la sintesis de macrolidos de halicondrina y analogos de los mismos. |
| MX2020006945A (es) | 2018-01-03 | 2020-11-09 | Eisai R&D Man Co Ltd | Reaccion de prins y compuestos utiles en la sintesis de macrolidos de halicondrina y analogos de los mismos. |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5010099A (en) | 1989-08-11 | 1991-04-23 | Harbor Branch Oceanographic Institution, Inc. | Discodermolide compounds, compositions containing same and method of preparation and use |
| GB9315802D0 (en) | 1993-07-30 | 1993-09-15 | Roussel Lab Ltd | Chemical compounds |
| US5681847A (en) * | 1995-12-05 | 1997-10-28 | Harbor Branch Oceanographic Institution, Inc. | Methods of using discodermolide compounds |
| US6242616B1 (en) * | 1996-12-03 | 2001-06-05 | The Trustees Of The University Of Pennsylvania | Synthetic techniques and intermediates for polyhydroxy, dienyl lactone derivatives |
| US5789605A (en) | 1996-12-03 | 1998-08-04 | Trustees Of The University Of Pennsylvania | Synthetic techniques and intermediates for polyhydroxy, dienyl lactones and mimics thereof |
| AU2001247241A1 (en) | 2000-03-01 | 2001-09-12 | Harbor Branch Oceanographic Institution, Inc. | Biologically active analogs of discodermolide |
-
2000
- 2000-12-06 US US09/730,929 patent/US6870058B2/en not_active Expired - Lifetime
-
2001
- 2001-12-06 AU AU2002227375A patent/AU2002227375A1/en not_active Abandoned
- 2001-12-06 CN CNA018201695A patent/CN101389619A/zh active Pending
- 2001-12-06 IL IL15622401A patent/IL156224A0/xx unknown
- 2001-12-06 KR KR10-2003-7007558A patent/KR20040062418A/ko not_active Application Discontinuation
- 2001-12-06 EP EP01996231A patent/EP1585725A4/en not_active Withdrawn
- 2001-12-06 WO PCT/US2001/047958 patent/WO2002046150A2/en not_active Application Discontinuation
- 2001-12-06 CA CA002431045A patent/CA2431045A1/en not_active Abandoned
-
2003
- 2003-05-30 ZA ZA200304259A patent/ZA200304259B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20040062418A (ko) | 2004-07-07 |
| WO2002046150A2 (en) | 2002-06-13 |
| EP1585725A4 (en) | 2006-06-07 |
| AU2002227375A1 (en) | 2002-06-18 |
| WO2002046150A3 (en) | 2006-01-05 |
| US20020103387A1 (en) | 2002-08-01 |
| CA2431045A1 (en) | 2002-06-13 |
| CN101389619A (zh) | 2009-03-18 |
| US6870058B2 (en) | 2005-03-22 |
| EP1585725A2 (en) | 2005-10-19 |
| ZA200304259B (en) | 2005-04-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL156224A0 (en) | Compounds which mimic the chemical and biological properties of discodermolide | |
| HU0303488D0 (en) | Oxidation of dangerous chemical and biological substances | |
| AUPR879601A0 (en) | Novel chemical compounds and their use | |
| AUPR283801A0 (en) | Chemical compounds and methods | |
| AU2001279135A1 (en) | Biosensors, reagents and diagnostic applications of directed evolution | |
| EP1402053A4 (en) | CHDS AS MODULATORS OF THE MECHANISM OF ACTION OF P53 AND USES THEREOF | |
| AU7595701A (en) | Surfaces that resist the adsorption of biological species | |
| HK1073618A1 (en) | Enhanced formulations for neutralization of chemical, biological and industrial toxants | |
| EP1421384A4 (en) | HPRP4 AS MODIFIERS OF THE P53 ROUTE AND THEIR METHODS OF USE | |
| EP1269877A3 (de) | Bekleidungsstück zum Schutz gegen chemische und/oder biologische Substanzen | |
| EP1329722A4 (en) | ANALYSIS METHOD USING OXYDO-REDUCTION REACTION | |
| GB0011957D0 (en) | The removal of chemical and biological agents from air | |
| AU2002367947A1 (en) | Chemical and biological hazard sensor system and methods thereof | |
| AU7457101A (en) | Micro-array of organism-associated substance | |
| GB0314840D0 (en) | Genetic analysis of microorganisms | |
| EA200101260A1 (ru) | Способ изменения физико-химических и/или биологических свойств вещества | |
| IL160177A0 (en) | Compounds which mimic the chemical and biological properties of discodermolide | |
| EG22826A (en) | Chemical compounds used as insecticides and fungicides | |
| AU2002255501A1 (en) | Tissue-based standoff biosensors for detecting chemical or biological warfare agents | |
| GB9929702D0 (en) | Chemical compounds and their uses | |
| AU2002218460A8 (en) | Transportation of biological specimens | |
| AU6418200A (en) | Analysis of biological fluids | |
| AU2001256264A1 (en) | Device for implementing chemical or biological methods | |
| AU3075202A (en) | Compositions and methods for the discovery and selection of biological information | |
| AUPR879801A0 (en) | Novel chemical compounds and their use |