IL152110A0 - Expression system for efficiently producing clinically effective lysosomal enzymes (glucocerebrosidase) - Google Patents

Expression system for efficiently producing clinically effective lysosomal enzymes (glucocerebrosidase)

Info

Publication number
IL152110A0
IL152110A0 IL15211001A IL15211001A IL152110A0 IL 152110 A0 IL152110 A0 IL 152110A0 IL 15211001 A IL15211001 A IL 15211001A IL 15211001 A IL15211001 A IL 15211001A IL 152110 A0 IL152110 A0 IL 152110A0
Authority
IL
Israel
Prior art keywords
glucocerebrosidase
expression system
efficiently producing
clinically effective
lysosomal enzymes
Prior art date
Application number
IL15211001A
Other languages
English (en)
Original Assignee
Exegenics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Exegenics Inc filed Critical Exegenics Inc
Publication of IL152110A0 publication Critical patent/IL152110A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01045—Glucosylceramidase (3.2.1.45), i.e. beta-glucocerebrosidase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL15211001A 2000-04-06 2001-04-06 Expression system for efficiently producing clinically effective lysosomal enzymes (glucocerebrosidase) IL152110A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19559800P 2000-04-06 2000-04-06
PCT/US2001/011144 WO2001077307A2 (en) 2000-04-06 2001-04-06 Expression system for efficiently producing clinically effective lysosomal enzymes (glucocerebrosidase)

Publications (1)

Publication Number Publication Date
IL152110A0 true IL152110A0 (en) 2003-07-31

Family

ID=22722012

Family Applications (1)

Application Number Title Priority Date Filing Date
IL15211001A IL152110A0 (en) 2000-04-06 2001-04-06 Expression system for efficiently producing clinically effective lysosomal enzymes (glucocerebrosidase)

Country Status (6)

Country Link
US (1) US20030215435A1 (xx)
EP (1) EP1272620A2 (xx)
AU (1) AU2001253181A1 (xx)
CA (1) CA2405120A1 (xx)
IL (1) IL152110A0 (xx)
WO (1) WO2001077307A2 (xx)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7723296B2 (en) * 2001-01-18 2010-05-25 Genzyme Corporation Methods for introducing mannose-6-phosphate and other oligosaccharides onto glycoproteins and its application thereof
WO2004091475A2 (en) 2003-04-16 2004-10-28 Yeda Research And Development Co. Ltd. Gaucher disease drugs and methods of identifying same
WO2006007560A2 (en) 2004-07-01 2006-01-19 University Of Pennsylvania Targeted protein replacement for the treatment of lysosomal storage disorders
EP2361613B1 (en) 2006-02-07 2020-08-12 Shire Human Genetic Therapies, Inc. Stabilized compositions of proteins having a free thiol moiety
EP2160403B1 (en) * 2007-05-11 2018-08-08 Genzyme Corporation Methods of producing a secreted protein
FR2926563B1 (fr) * 2008-01-21 2013-04-26 Biomerieux Sa Procede de detection et/ou d'identification de clostridium difficile
PT2638152T (pt) 2010-11-08 2016-10-25 Amicus Therapeutics Inc Proteínas beta-glucocerebrosidase recombinantes, variantes com estabilidade aumentada e atividade catalítica residual aumentada
EP3741384A1 (en) 2011-09-07 2020-11-25 Mount Sinai School Of Medicine Ceramidase and cell differentiation
CN102517301B (zh) * 2011-12-16 2013-09-25 西南大学 转录激活因子ie1
CN104582770B (zh) 2012-06-01 2019-01-29 西奈山伊坎医学院 在感染的治疗和预防中的神经酰胺水平
PT2968479T (pt) 2013-03-14 2019-08-07 Icahn School Med Mount Sinai Composições terapêuticas de ceramidase ácida e métodos de fabrico e utilização

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5879680A (en) * 1987-12-23 1999-03-09 The United States Of America As Represented By The Department Of Health And Human Services Cloned DNA for synthesizing unique glucocerebrosidase
AU2946289A (en) * 1987-12-23 1989-07-19 United States of America, as represented by the Secretary, U.S. Department of Commerce, The Cloned dna for synthesizing unique glucocerebrosidase
WO1990007573A1 (en) * 1988-12-23 1990-07-12 Genzyme Corporation Enzymatically active recombinant glucocerebrosidase
US5236838A (en) * 1988-12-23 1993-08-17 Genzyme Corporation Enzymatically active recombinant glucocerebrosidase
US5549892A (en) * 1988-12-23 1996-08-27 Genzyme Corporation Enhanced in vivo uptake of glucocerebrosidase
CA2179394A1 (en) * 1993-12-23 1995-06-29 Kostas Iatrou Methods of expressing proteins in insect cells and methods of killing insects
EP0865499B1 (en) * 1995-09-14 2009-03-18 Virginia Tech Intellectual Properties, Inc. Production of lysosomal enzymes in plant-based expression systems
IL150314A0 (en) * 1999-12-30 2002-12-01 Maxygen Aps Improved lysosomal enzymes and lysosomal enzyme activators

Also Published As

Publication number Publication date
AU2001253181A1 (en) 2001-10-23
EP1272620A2 (en) 2003-01-08
WO2001077307A2 (en) 2001-10-18
CA2405120A1 (en) 2001-10-18
WO2001077307A3 (en) 2002-03-21
US20030215435A1 (en) 2003-11-20

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